Abstract
The kallikrein-kinin system has been thought to participate in the pathogenesis of anaphylaxis. Kallikrein, released from lungs, has been postulated to contribute to cardiovascular collapse. Further to test the hypothesis, we examined for the occurrence of a kallikrein-like enzyme in guinea pig lungs and. examined for release of such an enzyme by isolated, perfused lungs of guinea pig sensitized to and challenged with egg albumin. In addition, we treated guinea pigs with the bradykinin potentiating agents, BPP9a and SQ 14,225. In parallel experiments, we examined for effects of non-steroidal anti-inflammatory agents on the supposition that prostaglandin-related substances may mediate or modulate actions of kinins during anaphylaxis. A plasma kallikrein-like enzyme was found in lung homogenates and occurred in concentrations greater than that of plasma itself. Similarly, a store of kininogen occurs in lungs. However, using a sensitive radioassay for kallikrein-like enzymes, we were unable to confirm that antigenic challenge of sensitized lungs causes the release of enzyme into pulmonary venous effluent. Further, we were unable to modify the acute course of anaphylaxis by pretreatment of guinea pigs with bradykinin potentiating agents. However, indomethacin and aspirin at 20–40 mg/kg were found to greatly increase the severity of pulmonary anaphylaxis in terms of increased resistance to ventilation and increased numbers of lung hemorrhages. Paradoxically, aspirin or sodium salicylate at 80–100 mg/kg prevents the characteristic rise of insufflation pressure and the formation of lung hemorrhages.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adcock, T.J., L.G. Garland, S. Moncada and J.A. Salmon, 1978. Enhancement of anaphylactic mediator release from guinea-pig perfused lungs by fatty acid hydroperoxides, Prostaglandins 16: 163.
Adcock, J.J., L.G. Garland, S. Moncada and J.A. Salmon, 1978. The mechanisms of enchancement by fatty acid hydroperoxides of anaphylactic mediator release. Prostaglandins 16: 179.
Amundsen, E., L. Svendsen, A.M. Venner$id and K. Laake, Determination of plasma kallikrein with a new chromogen.ic tripeptide derivative, 1976 In: Chemistry and Biology of the Kallikrein-Kinin System in Health and Disease. Fogarty Int. Center Proc. No 27, eds. J.J. Pisano and K.F. Austen (U.S. Government Printing Office, Washington ) p. 215.
Austen, K.F., 1974. Reaction mechanisms in the release of mediators of immediate hypersensitivity from human lung tissue. Fed. Proc. 33: 2256.
Beraldo, W.T., 1950. Formation of bradykinin in anaphylactic and peptone shock. Am. J. Physiol., 163: 283.
Brocklehurst, W.E. and S.C. Lahíri, 1962. The production of bradykinin in anaphylaxis, J. Physiol., 160: 15.
Brocklehurst, W.E. and S.C. Lahiri, 1963. Formation and destruction of bradykinin during anaphylaxis. J. Physiol., 165: 39.
Chung, A.C., J.W. Ryan, G. Pena and N.B. Oza. (this volume), A simple radioassay for human urinary kallikrein.
Collier, H.O.J. Role of the kallikrein-kinin system in lung diseases, 1976 In: Chemistry and Biology of the KallikreinKinin System in Health and Disease. Fogarty Int. Center Proc. No. 27, eds. J.J. Pisano and K.F. Austen (U.S. Government Printing Office, Washington ) p. 495.
Engineer, D.M., U. Niederhauser, P.J. Piper and P. Sirois, 1978. Release of mediators of anaphylaxis: Inhibition of prostaglandin synthesis and the modification of release of slow reacting substances on anaphylaxis and histamine. Br. J. Pharmac. 62: 61.
Jonasson, O. and E.L. Becker, 1966. Release of kallikrein from guinea pig lung during anaphylaxis. J. Exp. Med., 123: 509.
Levi, R., G. Allan and J.H. Zavecz, 1976. Cardiac histamine receptors. Fed. Proc., 35: 1942.
Newball, H.H., S.D. Revak, C.G. Cochrane, J.H. Griffin and L.M. Lichtenstein, 1978. Cleavage of hageman factor (HF) by a basophil kallikrein of anaphylaxis (BK-A). Clin. Res., 26: 519A.
Newball, H.H., R.C. Talamo and L.M. Lichtenstein, 1975. Release of leukocyte kallikrein mediated by IgE, Nature 254: 635
Rocha e Silva, M., W.T. Beraldo and G. Rosenfeld, 1949. Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma by snake venoms and by trypsin. Am. J. Physiol., 156: 261.
Ryan, J.W., A Chung, C. Ammons and M.L. Carlton, 1977. A simple radioassay for angiotensin converting enzyme. Biochem. J., 167: 501.
Ryan, J.W., A. Chung, L.C. Martin and U.S. Ryan, 1978. New substrates for the radioassay of angiotensin converting enzyme of endothelial cells in culture. Tissue & Cell. 10: 555.
Ryan, J.W., J. Roblero and J.M. Stewart, 1968. Inactivation of bradykinin in the pulmonary circulation. Biochem. J., 110: 795.
Ryan, J.W., J. Roblero and J.M. Stewart, 1970. Inactivation of bradykinin in rat lung. Adv. Exp. Med. Biol., 8: 263.
Ryan, J.W. and U.S. Ryan, 1977. Pulmonary endothelial cells. Fed. Proc., 36: 2683.
Vargaftig, B.B. and N. Dao, 1971. Release of vasoactive substances from guinea pig lungs by slow-reacting substance C and arachi® donic acid. Pharmacology 6: 99.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 Springer Science+Business Media New York
About this chapter
Cite this chapter
Oza, N.B., Ryan, J.W., Ryan, U.S., Berryer, P., Pena, G. (1979). Pulmonary Anaphylaxis and the Kallikrein-Kinin System. In: Fujii, S., Moriya, H., Suzuki, T. (eds) Kinins—II. Advances in Experimental Medicine and Biology, vol 120. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-0926-1_43
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0926-1_43
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4757-0928-5
Online ISBN: 978-1-4757-0926-1
eBook Packages: Springer Book Archive