Kinins—II pp 461-471 | Cite as

Effect of Kallikrein-Kinin System on Ion Transport Across Rat Small Intestine

  • Chiaki Moriwaki
  • Hiroyuki Fujimori
Part of the Advances in Experimental Medicine and Biology book series (AEMB)


Previously we have reported on the influence of the kallikreinkinin system on the active transport of amino acids and glucose across the rat small intestines (Moriwaki and Fukimori, 1975; Moriwaki et al., 1977) and the effect of kinin on accumulation of valine into the intestinal segment (Moriwaki et al., 1977). It has been recognized that some amino acids or glucose are co-transported with Na in the small intestines (Crane, 1965; Rosenberg et al., 1965). It is a well-known fact that an active solute transport is associated with an increase in transmural potential difference (PDt) of the small intestines (Barry et al., 1964; Schultz and Zalusky, 1964; Lyon and Crane, 1966; Hoshi and Komatsu, 1968). Meanwhile, Okada et al. (1977b) has demonstrated that the resistance of the intestines was not altered by the addition of glucose and glycine in the mucosal fluid. Therefore, the enhancement of absorption of glucose and amino acids in the intestines seems to be the result of the stimulation of Na+ flux in the absorptive cells by the kinins.


Intestinal Segment Serosal Side Jejunum Segment Mucosal Side Rabbit Ileum 
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Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • Chiaki Moriwaki
    • 1
  • Hiroyuki Fujimori
    • 1
  1. 1.Faculty of Pharmaceutical SciencesScience University of TokyoIchigaya Funakawara-Machi, Shinjuku-ku, TokyoJapan

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