Nechanism of Substance P-Induced Salivary Secretion in Rats
Leeman and Hammerschlag (1,2) found a potent sialogogic substance in the rough extract from bovine or rat hypothalamus. This sialogogue has been known to be substance P itself. Although substance P (SP), one of tachykinins, has been recognized as a neurotransmitter (3,4) or a modulator (5,6) of the primary sensory neurone, mechanism of sialogogic action of this substance still remained undissolved.
KeywordsArachidonic Acid Salivary Secretion Amylase Secretion Ringer Table Hexamethonium Bromide
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- 1.Hammerschlag, R. and Leeman, S.E., 1966, Induction of salivation a bovirie hypothalamic factor, Fed. Ploc. 25, 192.Google Scholar
- 5.Pïrivoy, W., Lane, M. and Kroeger, D., 1963 The actions of certain polypeptides on synaptic transmission, Ann N. Y. Acad. Scia 104, 312.Google Scholar
- 6.Hedqvist, P. and von Euler, U.S., 1977, Effects of substance P on some autonomic neuroeffector junctions, in Substance P eds. U.S.von Euler and B. Pernow ( Raven Press, New York ) p. 89.Google Scholar
- 7.Hökfelt, T., Johansson, O., Kellerth, J.-G., Ljungdahl, Nilsson, G., Nyards, A. and Pernow, B., 1977, Immunohistochemical distribution of substance P, in Substance P eds, U.S. von Euler and B. Pernow ( Raven Press, New York ) p. 117.Google Scholar