Kinins—II pp 351-361 | Cite as

Some Properties of Acrosin, a Kininogenase from Sperm Acrosome

  • Chiaki Moriwaki
  • Satoru Kaneko
Part of the Advances in Experimental Medicine and Biology book series (AEMB)


Acrosin is a protease in the mammalian sperm head, acrosome (Fritz et al., 1975) and its physiological role in the fertilization processes is thought to participate in the sperm penetration to ovum. This enzyme is classified as one of the serine protesses, such as trypsin and kallikreins (Fritz et ale, 1975). On the other hand, it has been reported that administrations of hog pancreatic kallikrein to male infertility patients, especially oligozoospermia and asthenozoospermia caused improvement of sperm counts and motility (Schill, 1977; Leidl, et al., 1974). Fritz et al. described that the kinin system enhances sperm motility, O2-consumption and fructolysis, in vitro (Schill, 1974).


Seminal Plasma Vasodilator Activity Sheep Erythrocyte Hemagglutination Activity Boar Sperm 
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  1. Fritz, H., W.D. Schleuning, H. Schiessler, W.B. Schill, V, Wendet and C. Winkler, 1975, Boar, bull and human sperm acrosinIsolation, properties and biological aspects: Proteases and biological control ( Cold Spring Harbor Laboratory, New York) p, 715.Google Scholar
  2. Haino, K., 1971. Studies on the egg-membrane lysin of Tegula Pfeifferi: Purification and properties of the egg membrane lyin. Biochim. Biophys. Acta 229: 459.Google Scholar
  3. Leider, W., R. Prinzen, W.B. Schill and H. Fritz, 1974. The effect of kallikrein on motility and metabolism of spermatozoa; Kininogenases 2 (F.K. Schattauer Verlag, Stuttgart, New York) p, 33.Google Scholar
  4. Moriwaki, C., Y. Hojima and H. Moriya, 1974. A proposal– use of combined assays of kallikrein activity measurement. Chem, Pharm. Bull. 22: 975.Google Scholar
  5. Moriya,H., K. Yamazaki, H. Fukushima and C. Moriwaki, 1965. Biochemical studies on kallikreins and their related substances, J. Biochem., 58: 208.PubMedGoogle Scholar
  6. Schill, W.B., 1974. Influence of the kallikrein-kinin system on human sperm motility in vitro Kininogenases 2 (F.K. Schattauer Verlag, Stuttgart, New York ) p. 47.Google Scholar
  7. Schill, W.B., 1977. Kallikrein as a therapeutical means in the treatment of male motility, Kininogenases 4 ( F.K. Schattauer Verlag, Stuttgart, New York ) p. 251.Google Scholar
  8. Schwert, G.W. and Y. Takenaka, 1955. A spectrophotometric determination of trypsin and chymotrypsin. Biochim. Biophys. Acta 16: 570.Google Scholar

Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • Chiaki Moriwaki
    • 1
  • Satoru Kaneko
    • 1
  1. 1.Faculty of Pharmaceutical ScienceScience University of TokyoIchigaya Funagawara-Machi, Sinjuku-kuJapan

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