The Photoimmunology of Delayed-Type Hypersensitivity and Its Relationship to Photocarcinogenesis

  • Edward C. De Fabo
  • Frances P. Noonan
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 68)


The association between skin cancer and ultraviolet radiation has been known for a long time. In 1934, it was demonstrated that by filtering sunlight with ordinary window glass and then exposing white rats to this light the carcinogenic activity associated with unfiltered sunlight was eliminated.1 This suggested that the carcinogenic wavelengths had to be between 290 nm, the approximate lower wavelength limit of sunlight penetration through the atmosphere2 and 320 nm radiation, the approximate lower wavelength limit of penetration through window glass. This waveband is commonly defined as UVB. Since that time a large amount of circumstantial data supporting the role of sunlight (UVB) in at least three types of human skin cancer has accrued.2 These three types are basal cell epitheliomas, squanous cell carcinomas and melanoma.


Stratum Corneum Suppressor Cell Action Spectrum Contact Hypersensitivity Immunologic Alteration 
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Edward C. De Fabo
    • 1
  • Frances P. Noonan
    • 2
  1. 1.Department of DermatologyGeorge Washington University School of Medicine and Health SciencesU.S.A.
  2. 2.1st Department of DermatologyUniversity of ViennaAustria

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