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Epilogue

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Pathological Neurochemistry

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Abstract

The publication of these ten volumes stirs my wonder and imagination about general aspects of the development of the sciences in the changing world. My knowledge of history is superficial but it seems that experimental chemistry started with alchemy, the search for the magic of gold, though the idea of ultimate particles was in the minds of classical Greek thinkers. Chemical study of biological materials started with von Liebig and others but got largely diverted into particular interest in carbon compounds though that subject was and is still called organic chemistry. Biological chemistry and related subjects started later in medical and agricultural faculties and developed rapidly as research interest and support came to medical scientists, particularly physiologists. Nevertheless, biochemistry, including neurochemistry, has its foundation in organic chemistry; some of the early work on brain chemistry, by Thudichum, Irvine Page, and others, was confined to the structure of prominent substances in brain. I even feel a little relevance of my own work in 1927 in organic chemistry on steric hindrance. Knowledge of space relations of atoms is now basic to descriptions of nucleic acids, receptor groups, etc.

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References

  1. Funk, C., 1914, Die Vitamine, Bergmann, Wiesbaden.

    Google Scholar 

  2. Rosenberg, L. E., 1974, Brain Dysfunction in Metabolic Disorders (F. Plumb, ed.), Raven Press, New York, pp. 263–271.

    Google Scholar 

  3. Arakawa, T., 1970, Am. J. Med. 48:594–598.

    Article  PubMed  CAS  Google Scholar 

  4. Spector, R., 1977, N. Engl. J. Med. 296:1393–1398.

    Article  PubMed  CAS  Google Scholar 

  5. Spector, R., 1978, J. Neurochem. 30:881–887.

    Article  PubMed  CAS  Google Scholar 

  6. Spector, R., and Greenwald, L. L., 1978, J. Biol. Chem. 253:2373–2379.

    PubMed  CAS  Google Scholar 

  7. Spector, R., 1979, Neurology, Psychiatry and Internal Medicine (I. M. Botez and E. H. Reynolds, eds.) Raven Press, New York, pp. 187–194.

    Google Scholar 

  8. Spector, R., 1979, J. Neurochem. 33:895–904.

    Article  PubMed  CAS  Google Scholar 

  9. Dreyfus, P. M., 1959, J. Neurochem. 4:183–190.

    Article  PubMed  CAS  Google Scholar 

  10. Pincus, J. H., and Grove, I., 1970, Exp. Neurol. 28:477–483.

    Article  PubMed  CAS  Google Scholar 

  11. Dreyfus, P. M., and Geel, S. E., 1981, Basic Neurochemistry (G. J. Siegel, R. W. Albers, B. W. Agranoff, and R. Katzman, eds.), 3rd ed., Little, Brown, Boston, pp. 661–679.

    Google Scholar 

  12. Dreyfus, P. M., and Hauser, G., 1965, Biochim. Biophys. Acta 164:78–84.

    Article  Google Scholar 

  13. Dreyfus, P. M., 1965, J. Neuropathol. Exp. Neurol. 24:119–129.

    Article  PubMed  CAS  Google Scholar 

  14. Dreyfus, P. M., 1961, J. Neurochem. 8:139–145.

    Article  PubMed  CAS  Google Scholar 

  15. Rindi, G., Patrini, C., Comincioli, V., and Reggiani, C., 1980, Brain Res. 181:369–380.

    Article  PubMed  CAS  Google Scholar 

  16. McCandless, D. W., and Schenker, S., 1968, J. Clin. Invest. 47:2268–2280.

    Article  PubMed  CAS  Google Scholar 

  17. Sharp, F. R., Evans, K., and Bolger, E., 1982, Neurology 32:808–814.

    Article  PubMed  CAS  Google Scholar 

  18. Voorhees, C. V., Schmidt, D. E., Barrett, R. J., and Schenker, S., 1977, J. Nutr. 107:1902–1908.

    Google Scholar 

  19. Heinrich, C. P., Stadler, H., and Weiser, H., 1973, J. Neurochem. 21:1273–1281.

    Article  PubMed  CAS  Google Scholar 

  20. Sacchi, O., Ladinsky, H., Prigioni, I., Consolo, S., Peri, G., and Perri, V., 1978, Brain Res. 151:609–614.

    Article  PubMed  CAS  Google Scholar 

  21. Barclay, L. L., Gibson, G. E., and Blass, J. P., 1981, J. Pharmacol. Exp. Ther. 217:537–543.

    PubMed  CAS  Google Scholar 

  22. McCandless, D. W., Curley, A. D., and Cassidy, C. E., 1976, J. Nutr. 106:1144–1151.

    PubMed  CAS  Google Scholar 

  23. Volpe, J. J., and Marasa, J. C., 1978, J. Neurochem. 30:975–981.

    Article  PubMed  CAS  Google Scholar 

  24. Schwartz, J. P., and McCandless, D. W., 1976, Mol. Cell. Biochem. 13:49–53.

    Article  PubMed  CAS  Google Scholar 

  25. Henderson, G. L, Hoyumpa, A. M., Jr., and Schenker, S., 1978, Biochem. Pharmacol. 27:1677–1683.

    Article  PubMed  CAS  Google Scholar 

  26. Barchi, R. L., and Braun, P. E., 1971, Brain Res. 35:622–624.

    Article  PubMed  CAS  Google Scholar 

  27. Geel, S. E., and Dreyfus, P. M., 1975, J. Neurochem. 24:353–360.

    Article  PubMed  CAS  Google Scholar 

  28. Trostler, N., and Sklar, D., 1977, J. Nutr. Sci. Vitaminol. 24:105–111.

    Article  Google Scholar 

  29. Plaitakis, A., Nicklas, W. J., and Berl, S., 1978, Neurology 28:691–698.

    Article  PubMed  CAS  Google Scholar 

  30. Dreyfus, P. M., 1962, N. Engl. J. Med. 267:596–598.

    Article  PubMed  CAS  Google Scholar 

  31. Blass, J. P., and Gibson, G. E., 1977, N. Engl. J. Med. 297:1367–1370.

    Article  PubMed  CAS  Google Scholar 

  32. von Murait, A., 1962, Ann. N.Y. Acad. Sci. 98:499–507.

    Google Scholar 

  33. Itokawa, Y., Schulz, R. A., and Cooper, J. R., 1972, Biochim. Biophys. Acta 266:293–299.

    Article  PubMed  CAS  Google Scholar 

  34. Cooper, J. R., and Pincus, J. H., 1979, Neurochem. Res. 4:223–239.

    Article  PubMed  CAS  Google Scholar 

  35. Itokawa, Y., and Cooper, J. R., 1968, Biochim. Biophys. Acta 158:180–182.

    Article  PubMed  CAS  Google Scholar 

  36. Barchi, R. L., 1976, Thiamine (C. J. Gubler, M. Fujiwara, and P. M. Dreyfus, eds.), Wiley, New York, pp. 283–305.

    Google Scholar 

  37. Pincus, J. H., 1972, Dev. Med. Child Neurol. 14:87–101.

    Article  PubMed  CAS  Google Scholar 

  38. Pincus, J. H., Cooper, J. R., Piros, K., and Turner, V., 1974, Neurology 24:885–890.

    Article  PubMed  CAS  Google Scholar 

  39. Tang, T. T., Good, T. A., Dyken, P. R., Johnson, S. D., McCreadie, S. R., Sy, S. T., Lardy, H. A., and Rudolph, F. B., 1972, J. Pediatr. 81:189–190.

    Article  PubMed  CAS  Google Scholar 

  40. Blass, J. P., Avigan, J., and Uhlendorf, B. W., 1970, J. Clin. Invest. 49:423–432.

    Article  PubMed  CAS  Google Scholar 

  41. Elsas, L. J., Danner, D. J., and Rogers, B. L., 1976, Thiamine (C. J. Gubler, M. Fujiwara, and P. M. Dreyfus, eds.), Wiley, New York, pp. 335–349.

    Google Scholar 

  42. Bowden, J. A., McArthur, C. L., and Fried, M., 1971, Biochem. Med. 5:101–108.

    Article  PubMed  CAS  Google Scholar 

  43. Williams, M. A., 1964, Vitam. Horm. (N.Y.) 22:561–579.

    Article  CAS  Google Scholar 

  44. Lajtha, A. L., Maker, H. S., and Clarke, D. D., 1981, Basic Neurochemistry (G. J. Siegel, R. W. Albers, B. W. Agranoff, and R. Katzman, eds.), 3rd ed., Little, Brown, Boston, pp. 329 – 353.

    Google Scholar 

  45. Nitsch, C., 1980, J. Neurochem. 34:822–830.

    Article  PubMed  CAS  Google Scholar 

  46. Wiss, O., and Weber, F., 1964, Vitam. Horm. (N.Y.) 22:495–501.

    Article  CAS  Google Scholar 

  47. Bhagavan, H. N., and Coursin, D. B., 1971, Int. J. Vitam. Nutr. Res. 41:419–423.

    PubMed  CAS  Google Scholar 

  48. Morre, D. M., Kirksey, A., and Das, G. D., 1978, J. Nutr. 108:1250–1259.

    PubMed  CAS  Google Scholar 

  49. Morre, D. M., and Kirksey, A., 1978, Brain Res. 146:200–204.

    Article  PubMed  CAS  Google Scholar 

  50. Stephens, M. C., and Dakshinamurti, K., 1975, Neurobiology 5:262–269.

    PubMed  CAS  Google Scholar 

  51. Kurtz, D. J., and Kanfer, J. N., 1973, J. Neurochem. 20:963–968.

    Article  PubMed  CAS  Google Scholar 

  52. Hsia, E. Y., and Wolf, B., 1981, Basic Neurochemistry (G. J. Siegel, R. W. Albers, B. W. Agranoff, and R. Katzman, eds.), Little, Brown, Boston, pp. 563–600.

    Google Scholar 

  53. Lott, I. T., Coulombe, T., Di Paolo, R. V., Richardson, E. P., and Levy, H. L., 1978, Neurology 28:47–54.

    Article  PubMed  CAS  Google Scholar 

  54. Stadtman, T. C., 1971, Science 171:859–867.

    Article  PubMed  CAS  Google Scholar 

  55. Agamanolis, D. P., Victor, M., Chester, E. M., Kark, J. A., Hines, J. D., and Harris, J. W., 1976, Neurology 26:905–914.

    Article  PubMed  CAS  Google Scholar 

  56. Girwood, R. H., 1968, Proc. Nutr. Soc. 27:101–107.

    Article  Google Scholar 

  57. Cardinale, G. J., Dreyfus, P. M., Auld, P., and Abeles, R. H., 1969, Arch. Biochem. Biophys. 131:92–99.

    Article  PubMed  CAS  Google Scholar 

  58. Frenkel, E. P., 1973, J. Clin. Invest. 52:1237–1245.

    Article  PubMed  CAS  Google Scholar 

  59. Barley, F. W., Sato, G. H., and Abeles, R. H., 1972, J. Biol. Chem. 247:4270–4276.

    PubMed  CAS  Google Scholar 

  60. Kishimoto, Y., Williams, M., Moser, H. W., Hignite, C., and Biemann, K., 1973, J. Lipid Res. 14:69–77.

    PubMed  CAS  Google Scholar 

  61. Frenkel, E. P., Kitchens, R. L., and Johnston, J. M., 1973, J. Biol. Chem. 248:7540–7546.

    CAS  Google Scholar 

  62. Amess, J. A. L., Burman, J. F., Rees, G. M., Nancekievill, D. G., and Mollin, D. L., 1978, Lancet 2:339–342.

    Article  PubMed  CAS  Google Scholar 

  63. Lassen, H. C. A., Henricksen, E., Neukirch, F., and Kirsten, H. S., 1956, Lancet 1:527–530.

    Article  Google Scholar 

  64. Layzer, R., Fishman, R. A., and Schafer, J. A., 1978, Neurology 28:504–506.

    Article  PubMed  CAS  Google Scholar 

  65. Kondo, H., Osborne, M. L., Kolhouse, J. F., Binder, M. J., Podell, E. R., Utley, C. S., Abrams, R. S., and Allen, R. H., 1981, J. Clin. Invest. 67:1270–1283.

    Article  PubMed  CAS  Google Scholar 

  66. Scott, J. M., Wilson, P., Dinn, J. J., and Weir, D. G., 1981, Lancet 2:334–337.

    Article  PubMed  CAS  Google Scholar 

  67. Scott, J. M., and Weir, D. G., 1981, Lancet 2:337–340.

    Article  PubMed  CAS  Google Scholar 

  68. Stokstad, E. L. R., 1976, Present Knowledge in Nutrition, 4th ed., The Nutrition Foundation, New York, pp. 204–216.

    Google Scholar 

  69. Ordonez, L. A., 1979, Folic Acid in Neurology, Psychiatry, and Internal Medicine (M. I. Botez and E. H. Reynolds, eds.), Raven Press, New York, pp. 129–145.

    Google Scholar 

  70. Girwood, R. H., 1968, Proc. Nutr. Soc. 27:101–107.

    Article  Google Scholar 

  71. Meller, E., and Friedhoff, A. J., 1979, Folic Acid in Neurology, Psychiatry, and Internal Medicine, (M. I. Botez and E. H. Reynolds, eds.), Raven Press, New York, pp. 157–177.

    Google Scholar 

  72. Hommes, O. R., Hollinger, M. J. T., Jansen, M., Schoofs, M., Vanderwiel, T., and Kok, J. C. N., 1979, Folic Acid in Neurology, Psychiatry, and Internal Medicine (M. I. Botez and E. H. Reynolds, eds.) Raven Press, New York, pp. 285–316.

    Google Scholar 

  73. Smith, D. B., and Obbens, E. A. M. T., 1979, Folic Acid in Neurology, Psychiatry, and Internal Medicine (M. I. Botez and E. H. Reynolds, eds.), Raven Press, New York, pp. 267–283.

    Google Scholar 

  74. Darby, W. J., McNutt, K. W., and Todhunter, E. N., 1976, Present Knowledge in Nutrition, 4th ed., The Nutrition Foundation, New York, pp. 162–174.

    Google Scholar 

  75. Wolf, A., Cowen, D., and Geller, L. M., 1959, Trans. Am. Neurol. Assoc. 84:140–145.

    PubMed  CAS  Google Scholar 

  76. Herken, H., Lange, K., Kolbe, H., and Keller, K., 1974, Central Nervous System—Studies on Metabolic Regulation and Function (E. Genazzani and H. Herken, eds.), Springer, Berlin, pp. 41–54.

    Chapter  Google Scholar 

  77. Wright, L. D., 1976, Present Knowledge in Nutriton, 4th ed., The Nutrition Foundation, New York, pp. 226–231.

    Google Scholar 

  78. Novelli, G. D., 1953, Physiol. Rev. 33:525–543.

    PubMed  CAS  Google Scholar 

  79. Bean, W. B., and Hodges, R. E., 1954, Proc. Soc. Exp. Biol. Med. 86:693–698.

    PubMed  CAS  Google Scholar 

  80. Sun, A. Y., and Sun, G. Y., 1978, Adv. Exp. Med. Biol. 97:295–289.

    Google Scholar 

  81. Vatassery, G. T., and Younoszai, R., 1978, Lipids 13:828–831.

    Article  PubMed  CAS  Google Scholar 

  82. Witting, L. A., 1969, J. Neurochem. 16:1253–1256.

    Article  PubMed  CAS  Google Scholar 

  83. McCormick, D. B., 1979, Present Knowledge in Nutrition, 4th ed., The Nutrition Foundation, New York, pp. 217–225.

    Google Scholar 

  84. Mock, D. M., DeLorimer, A. A., Liebman, W. M., Sweetman, L., and Baker, H., 1981, N. Engl. J. Med. 304:820–823.

    Article  PubMed  CAS  Google Scholar 

  85. Tanaska, K., 1981, N. Engl. J. Med. 304:839–840.

    Article  Google Scholar 

  86. Murthy, P. N., and Mistry, S. P., 1977, Prog. Food Nutr. Sci. 2:405–455.

    PubMed  CAS  Google Scholar 

  87. Bonjour, J. P., 1977, Int. J. Vitam. Nutr. Res. 47:107–118.

    PubMed  CAS  Google Scholar 

  88. Schrijver, J., Dias, T., and Hommes, O. R., 1979, Nutr. Metab. 23:179–191.

    Article  PubMed  CAS  Google Scholar 

  89. Bhagavan, H. N., and Coursin, D. B., 1974, Int. J. Vitam. Nutr. Res. 44:363–369.

    PubMed  CAS  Google Scholar 

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  1. Allan Elliott
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  1. Center for Neurochemistry, Wards Island, New York, USA

    Abel Lajtha

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Elliott, A. (1985). Epilogue. In: Lajtha, A. (eds) Pathological Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0797-7_29

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  • DOI: https://doi.org/10.1007/978-1-4757-0797-7_29

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