Abstract
Three hundred years ago, Syndenham recognized the use of iron as a specific remedy for chlorosis, now recognized as iron-deficiency (ID) anemia. Thus, iron was the first trace element known to be essential, and is the most abundant trace element in the body.1 The relatively large amount of iron found in the brain is unevenly distributed and shows a close similarity to the distribution of dopamine (DA) in various regions. In the brain, as in the periphery, iron is associated with hemin, heme-containing enzymes, is found as nonheme iron in many enzymes and structural proteins, and is also important for protein synthesis.
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Youdim, M.B.H. (1985). Brain Iron Metabolism. In: Lajtha, A. (eds) Pathological Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0797-7_27
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