Brain Iron Metabolism

Biochemical and Behavioral Aspects in Relation to Dopaminergic Neurotransmission
  • M. B. H. Youdim

Abstract

Three hundred years ago, Syndenham recognized the use of iron as a specific remedy for chlorosis, now recognized as iron-deficiency (ID) anemia. Thus, iron was the first trace element known to be essential, and is the most abundant trace element in the body.1 The relatively large amount of iron found in the brain is unevenly distributed and shows a close similarity to the distribution of dopamine (DA) in various regions. In the brain, as in the periphery, iron is associated with hemin, heme-containing enzymes, is found as nonheme iron in many enzymes and structural proteins, and is also important for protein synthesis.

Keywords

Iron Deficiency Iron Deficiency Anemia Globus Pallidus Brain Iron Nonheme Iron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Widdowson, E. M., 1969, Mineral Metabolism in Paediatrics (D. Barltrop and W. L. Burland, eds.), Adland, Dorking, p. 87.Google Scholar
  2. 2.
    Beutter, E., and Fairbanks, V. F., 1981, Iron in Biochemistry and Medicine II (A. Jacobs and M. Worwood, eds.), Academic Press, New York, pp. 394–425.Google Scholar
  3. 3.
    Jacobs, A., and Worwood, M. (ed.), 1974, Iron in Biochemistry and Medicine, Academic Press, New York.Google Scholar
  4. 4.
    Frieden, E., 1974, Protein-Metal Interactions (M. Friedman, ed.), Plenum Press, New York, pp. 1–32.CrossRefGoogle Scholar
  5. 5.
    Yasunobu, K. T., Mower, H. F., and Hayashi, O., 1975, Iron and Copper Proteins, Plenum Press, New York.Google Scholar
  6. 6.
    Garby, L., 1973, Clinics in Haematology (S. T. Callender, ed.), Saunders, Philadelphia, pp. 245–257.Google Scholar
  7. 7.
    Pollitt, E., and Leibel, R. L., 1976, J. Pediatr. 88:372–381.PubMedCrossRefGoogle Scholar
  8. 8.
    Youdim, M. B. H., and Iancu, T. C., 1977, Br. J. Haematol. 36:298–299.PubMedCrossRefGoogle Scholar
  9. 9.
    Pollitt, E., and Leibel, R. L. (eds.), 1982, Iron Deficiency, Brain Biochemistry and Behavior, Raven Press, New York.Google Scholar
  10. 10.
    Youdim, M. B. H., and Green, A. R., 1977, Iron Metabolism (R. Porter and W. Fitzsimons, eds.), Elsevier, Amsterdam, pp. 201–226.Google Scholar
  11. 11.
    Youdim, M. B. H., Yehuda, S., Ben-Shachar, D., and Ashkenazi, R., 1982, Iron Deficiency, Brain Biochemistry and Behavior (E. Pollitt and R. L. Leibel, eds.), Raven Press, New York, pp. 39–57.Google Scholar
  12. 12.
    Ashkenazi, R., Ben-Shachar, D., and Youdim, M. B. H., 1982, Pharmacol. Biochem. Behav. 17:43–48.PubMedCrossRefGoogle Scholar
  13. 13.
    Bogniard, R. P., and Whipple, G. H., 1932, J. Exp. Med. 55:653–658.PubMedCrossRefGoogle Scholar
  14. 14.
    Austoni, M. E., Rabinovitch, A., and Greenberg, D. M., 1940, J. Biol. Chem. 134:17–26.Google Scholar
  15. 15.
    Caraway, W. T., 1963, Clin. Chem. 9:188–196.PubMedGoogle Scholar
  16. 16.
    Jackson, A. J., Michael, L. M., and Schumacher, H. J., 1972, Anal. Chem. 44:1064–1065.PubMedCrossRefGoogle Scholar
  17. 17.
    Thunell, S., 1965, Clin. Chim. Acta 11 321–333.PubMedCrossRefGoogle Scholar
  18. 18.
    Vacha, J., Dungel, J., and Kleinwachter, V., 1978, Exp. Haematol. 6:718–724.Google Scholar
  19. 19.
    Weinfeld, A., 1964, Acta Med. Scand. 177(Suppl. 427):13–20.Google Scholar
  20. 20.
    Kejellin, K. G., 1966, J. Neurochem. 13:413–421.CrossRefGoogle Scholar
  21. 21.
    Perl, M., 1867, Virchows Arch. A 39:42–48.CrossRefGoogle Scholar
  22. 22.
    Cameron, B. F., 1970, Anal. Biochem. 35:515–517.CrossRefGoogle Scholar
  23. 23.
    Highman, B., 1942, Arch. Pathol. 33:937–943.Google Scholar
  24. 24.
    Jackson, A. J., Michael, L. M., and Schunacher, H. J., 1972, Anal. Chem. 44:1064–1065.PubMedCrossRefGoogle Scholar
  25. 25.
    Parmley, R. T., Spicer, S. S., and Alvarez, C. J., 1978, J. Histochem. Cytochem. 26:729–741.PubMedCrossRefGoogle Scholar
  26. 26.
    Thunell, S., 1965, Clin. Chim. Acta 11:321–333.PubMedCrossRefGoogle Scholar
  27. 27.
    Hukill, P. B., and Putt, F. A., 1962, J. Histochem. Cytochem. 10:490–494.CrossRefGoogle Scholar
  28. 28.
    Pearse, A. G. E., 1961, Histochemistry, 2nd ed., Little, Brown, Boston.Google Scholar
  29. 29.
    Humason, G. L., 1979, Animal Tissue Techniques, 4th ed., Freeman, San Francisco.Google Scholar
  30. 30.
    Nguyen-Legros, J., Bizot, J., Bolesse, J., and Pulicani, P., 1980, Histochemistry 66:239–244.PubMedCrossRefGoogle Scholar
  31. 31.
    Zaleski, S., 1887, Arch. Exp. Pathol. Pharmakol. 23:77–99.CrossRefGoogle Scholar
  32. 32.
    Guizzetti, P., 1915, Riv. Pat. Nerv. Ment. 20:103–117.Google Scholar
  33. 33.
    Spatz, H., 1922, Z. Gesamte Neurol. Psychiatr. 77:261–290.CrossRefGoogle Scholar
  34. 34.
    Spatz, H., and Metz, A., 1926, Z. Gesamte Neurol. Psychiatr. 100:428–449.CrossRefGoogle Scholar
  35. 35.
    Tingey, A. H., 1937, J. Ment. Sci. 83:451–460.Google Scholar
  36. 36.
    Cumings, N. J., 1948, Brain 71:410–415.PubMedCrossRefGoogle Scholar
  37. 37.
    Hallgren, B., and Sourander, P., 1958, J. Neurochem. 3:41–51.PubMedCrossRefGoogle Scholar
  38. 38.
    Sundermann, A., and Kempf, G., 1961, Z. Alternsforsch. 15:97–105.Google Scholar
  39. 39.
    Musil A., Bertha, H., Haas, W., and Waurschinek, O., 1962, Monatsh. 93L:536–540.Google Scholar
  40. 40.
    Courville, C. B., Nusbaum, R. E., and Butt, E. M., 1963, Arch. Neurol. 8:481–489.PubMedCrossRefGoogle Scholar
  41. 41.
    Harrison, W. W., Netsky, M. G., and Brown, M. D., 1968, Clin. Chim. Acta 21:55–61.PubMedCrossRefGoogle Scholar
  42. 42.
    Youdim, M. B. H., Green, A. R., Bloofield, M. R., Mitchell, B., Heal, D. J., and Grahame-Smith, D. G., 1980, Neuropharmacology 19:259–267.PubMedCrossRefGoogle Scholar
  43. 43.
    Rajan, K. S., Colburn, R. W., and Davis, J. M., 1971, J. Neurochem. 18:345–364.PubMedCrossRefGoogle Scholar
  44. 44.
    Rajan, K. S., Colburn, R. W., and Davis, J. M., 1976, Life Sci. 18:423–432.PubMedCrossRefGoogle Scholar
  45. 45.
    Hanig, R. C., and Aprison, M. H., 1967, Anal. Biochem. 21:169–177.PubMedCrossRefGoogle Scholar
  46. 46.
    Weiner, W. J., Nausiela, P. A., and Klawans, H., 1977, Life Sci. 20:1181–1185.PubMedCrossRefGoogle Scholar
  47. 47.
    Rafaelson, O. J., and Kofod, B., 1969, Handbook of Neurochemistry, Volume 6 (A. Lajtha, ed.), Plenum Press, New York, pp. 261–271.Google Scholar
  48. 48.
    Williamson, A. M., and Nj, K. T., 1980, Physiol. Behav. 24:561–567.PubMedCrossRefGoogle Scholar
  49. 49.
    Hill, J. M., and Switzer, R. C., III, 1984, Neuroscience 11:595–603.PubMedCrossRefGoogle Scholar
  50. 50.
    Colburn, R. W., and Mass, J. W., 1965, Nature 208:37–41.PubMedCrossRefGoogle Scholar
  51. 51.
    Columbo, J. A., and Saporta, A., 1980, Exp. Neurol. 70:417–437.Google Scholar
  52. 52.
    Norton, W. J., and Poduslo, S. E., 1973, J. Neurochem. 21:759–762.PubMedCrossRefGoogle Scholar
  53. 53.
    Davison, A. N., and Peters, A., 1970, Myelination, Thomas, Springfield, Illinois.Google Scholar
  54. 54.
    Dallman, P. R., and Spirito, R. A., 1977, J. Nutr. 107:1075–1081.PubMedGoogle Scholar
  55. 55.
    Kofod, B., 1970, Eur. J. Pharmacol. 13:40–45.PubMedCrossRefGoogle Scholar
  56. 56.
    Keen, O. L., and Hurley, L. S., 1980, Mech. Ageing Dev. 13:161–176.PubMedCrossRefGoogle Scholar
  57. 57.
    Dallman, P. R., Simes, M. A., and Manies, E. C., 1975, Br. J. Haematol. 31:209–215.PubMedCrossRefGoogle Scholar
  58. 58.
    Weinberg, J., Dallman, P. R., and Levine, S., 1979, Pharmacol. Biochem. Behav. 12:493–502.CrossRefGoogle Scholar
  59. 59.
    Dallman, P. R., 1974, Iron in Biochemistry and Medicine (A. Jacob and M. Worwood, eds.), Academic Press, New York, pp. 437–475.Google Scholar
  60. 60.
    W.H.O. Scientific Group on Nutritional Anaemias, 1968, W.H.O. Tech. Res. Ser. 405.Google Scholar
  61. 61.
    Ten-State Nutritional Survey 1968–1970, Volume IV, U.S. Department of Health, Education and Welfare, Publication (HSM) 72–8132.Google Scholar
  62. 62.
    Nutrition Canada, 1973, Nutritional Canada National Survey, Canadian Department of National Health and Welfare, Publication H 58–36–1973.Google Scholar
  63. 63.
    Kessner, J., and Kalk, A., 1973, Strategy for evaluating health services, Institute of Medicine, National Academy of Sciences, Washington, D.C.Google Scholar
  64. 64.
    HANES, 1974, 1971–1972 Dietary Intake and Biochemical Findings, U.S. Department of Health, Education and Welfare, Publication (HRA) 74–1219–1.Google Scholar
  65. 65.
    Lazoff, B., Britteenham, G., Viteri, F. E., and Urrutia, J. J., 1982, Iron Deficiency, Brain Biochemistry and Behavior (E. Pollitt and R. L. Leibel, eds.), Raven Press, New York, pp. 183–194.Google Scholar
  66. 66.
    Pollitt, E., Viteri, F., Saco-Pollitt, C., and Leibel, R. L., 1982, Iron Deficiency, Brain Biochemistry and Behavior (E. Pollitt and R. L. Leibel, eds.), Raven Press, New York, pp. 195–208.Google Scholar
  67. 67.
    Oski, F. A., and Honig, A.M., 1978, J. Pediatr. 92:21–25.PubMedCrossRefGoogle Scholar
  68. 68.
    Leibel, R., 1977, J. Am. Diet. Assoc. 71:398–404.PubMedGoogle Scholar
  69. 69.
    Leibel, R. L., Greenfield, D. B., and Pollitt, E., 1979, Nutrition Pre- and Postnatal Development (M. Winick, ed.), Plenum Press, New York.Google Scholar
  70. 70.
    Pollitt, E., Lewis, N., Leibel, R. L., and Greenfield, D. B., 1981, Human Nutrition: Clinical and Biochemical Aspects (P. J. Garry, ed.), American Association for Clinical Chemistry, Washington, D. C., pp. 290–301.Google Scholar
  71. 71.
    Oski, F. A., 1979, Am. J. Dis. Child. 133:315–322.PubMedGoogle Scholar
  72. 72.
    Webb, T., and Oski, F. A., 1973, J. Pediatr. 82:827–830.PubMedCrossRefGoogle Scholar
  73. 73.
    Cantwell, R. J., 1974, Pediatr. Res. 8:342.CrossRefGoogle Scholar
  74. 74.
    Saltman, P., and Hegenauer, J. (eds.), 1982, The Biochemistry and Physiology of Iron, Elsevier, Amsterdam.Google Scholar
  75. 75.
    Hamon, M., Bourgoin, S., and Youdim, M. B. H., 1979, Aromatic Amino Acid Hydroxylases and Mental Disease (M. B. H. Youdim, ed.), Wiley, New York, pp. 191–233.Google Scholar
  76. 76.
    Weiner, N., 1979, Aromatic Amino Acid Hydroxylases and Mental Disease (M. B. H. Youdim, ed.), Wiley, New York, pp. 141–190.Google Scholar
  77. 77.
    Lovenberg, W., 1983, Handbook of Neurochemistry, Volume 4 (A. Lathja, ed.), Plenum Press, New York, pp. 133–150.Google Scholar
  78. 78.
    Symes, A. L., Sourkes, T. L., Youdim, M. B. H., Gregoriades, G., and Birnbaum, H., 1969, Can. J. Biochem 47:999–1003.PubMedCrossRefGoogle Scholar
  79. 79.
    Symes, A. L., Missala, K., and Sourkes, T. L., 1971, Science 174:153–155.PubMedCrossRefGoogle Scholar
  80. 80.
    Youdim, M. B. H., Woods, H. F., Mitchel, D. B., Grahame-Smith, D. G., and Callender, D. S., 1975, Clin. Sci. Mol. Med. 48:289–295.PubMedGoogle Scholar
  81. 81.
    Voorhess, M. L., Stuart, M. J., Stockman, J. A., and Oski, F. A., 1975, J. Pediatr. 86:542–547.PubMedCrossRefGoogle Scholar
  82. 82.
    Grahame-Smith, D. G. (ed.), 1982, Psychopharmacology, Volumes 1 and 2, Excerpta-Medica, Amsterdam.Google Scholar
  83. 83.
    Pletscher, A., 1978, Essays in Neurochemistry and Neuropharmacology, Volume 4 (M. B. H. Youdim, W. Lovenberg, D. F. Sharman, and J. R. Lagnado, eds.), Wiley, New York, pp. 49–103.Google Scholar
  84. 84.
    Graf, M., and Pletscher, A., 1979, Br. J. Pharmacol. 65:601–608.PubMedCrossRefGoogle Scholar
  85. 85.
    Woods, H. F., Youdim, M. B. H., Boullin, D., and Callender, D. S., 1977, Ciba Found. Symp. 51:227–248.Google Scholar
  86. 86.
    Youdim, M. B. H., Ishalom, N., and Iancu, T., 1984, Br. J. Haematol, (in press).Google Scholar
  87. 87.
    Kaladhar, M., and Narasinga Rao, B. S., 1982, J. Neurochem. 38:1576–1581.PubMedCrossRefGoogle Scholar
  88. 88.
    Weisenberg, E., Halbreich, A., and Mager, J., 1980, Biochem. J. 188:633–641.PubMedGoogle Scholar
  89. 89.
    Massaro, T. F., 1982, Iron Deficiency, Brain Biochemistry and Behavior (E. Pollitt and R. L. Leibel, eds.), Raven Press, New York, pp. 125–140.Google Scholar
  90. 90.
    Edgerton, V. R., Ohira, Y., Gardner, G. W., and Senewiratne, B., 1982, Iron Deficiency, Brain Biochemistry and Behavior (E. Pollitt and R. L. Leibel, eds.), Raven Press, New York, pp. 141–160.Google Scholar
  91. 91.
    Mackler, B., Person, R., Miller, L. R., Inamdar, A. R., and Finch, C. A., 1978, Pediatr. Res. 12:217–220.PubMedCrossRefGoogle Scholar
  92. 92.
    Mackler, B., and Finch, C., 1982, Iron Deficiency, Brain Biochemistry and Behavior (E. Pollitt and R. L. Leibel, eds.), Raven Press, New York, pp. 31–38.Google Scholar
  93. 93.
    Youdim, M. B. H., and Ashkenazi, R., 1982, Serotonin in Biological Psychiatry (B. Ho and E. Usdin, eds.), Raven Press,. New York, pp. 35–51.Google Scholar
  94. 94.
    Tamir, H., Klein, A., and Rapport, M., 1976, J. Neurochem. 26:871–878.PubMedCrossRefGoogle Scholar
  95. 95.
    Tamir, H., and Gershen, M. D., 1979, J. Neurochem. 33:35–44.PubMedCrossRefGoogle Scholar
  96. 96.
    Tamir, H., Brunner, W., Casper, D., and Rapport, M., 1980, J. Neurochem. 34:1719–1724.PubMedCrossRefGoogle Scholar
  97. 97.
    Dillman, E., Gale, C., Green, W., Johnson, D. G., Madder, B., and Finch, C. A., 1980, Am. J. Physiol. 238:377–381.Google Scholar
  98. 98.
    Dillman, E., Johnson, D. G., Martin, J., Mackler, B., and Finch, C. A., 1979, Am. J. Physiol. 237:R297–300.Google Scholar
  99. 99.
    Dillman, E., Mackler, B., Johnson, D. G., Brengelman, G., Green, W., Gale, C., Martin, J., Layrisse, M., Martinez-Torres, C., and Finch, C., 1982, Iron Deficiency Brain Biochemistry and Behavior (E. Pollitt and R. L. Leibel, eds.), Raven Press, New York, pp. 57–62.Google Scholar
  100. 100.
    Leibel, R., Greenfeld, D., and Pollitt, E., 1979, Br. J. Haematol. 41:145–150.PubMedCrossRefGoogle Scholar
  101. 101.
    Anderson, H. T., and Barkve, H., 1970, Scand. J. Clin. Lab. Invest. 25:1–62.CrossRefGoogle Scholar
  102. 102.
    Gardner, G. W., Edgerton, V. R., Senewiratne, B., Barnard, R. J., and Ohira, Y., 1977, Am. J. Clin. Nutr. 30:910–917.PubMedGoogle Scholar
  103. 103.
    Ohira, Y., Edgerton, V. R., Gardner, G. W., Senewiratne, B., Barnard, R. J., and Simpson, D. R., 1979, Br. J. Haematol. 41:365–372.PubMedCrossRefGoogle Scholar
  104. 104.
    Viteri, F. E., and Torun, B., 1974, Clin. Haematol. :609–626.Google Scholar
  105. 105.
    Edgerton, V. R., Ohira, Y., Gardner, G. W., and Senewiratne, B., 1982, Iron Deficiency, Brain Biochemistry and Behavior (E. Pollitt and R. L. Leibel, eds.), Raven Press, New York, pp. 141–160.Google Scholar
  106. 106.
    Edgerton, V. R., Diamon, L. B., and Olson, J., 1977, J. Nutr. 102:381–399.Google Scholar
  107. 107.
    Edgerton, V. R., Diamon, L. B., and Olson, J., 1977, J. Nutr. 107:595–601.Google Scholar
  108. 108.
    Finch, C. A., Gollnick, P. D., Hlastada, M. P., Miller, L. R., Dillman, E., and Mackler, B., 1979, J. Clin. Invest. 64:129–137.PubMedCrossRefGoogle Scholar
  109. 109.
    Finch, C. A., Miller, L. R., Inamdar, A. R., Person, R., Seiler, K., and Mackler, B., 1976, J. Clin. Invest. 58:447–453.PubMedCrossRefGoogle Scholar
  110. 110.
    Ohira, Y., Edgerton, V. R., Gardner, G. W., Gunawardena, K. A., Senewiratne, B., and Ikawa, S., 1981, J. Nutr. Sci. Vitaminol. 27:87–96.PubMedCrossRefGoogle Scholar
  111. 111.
    Green, A. R., and Grahame-Smith, D. G., 1974, Neuropharmacology 13:949–959.PubMedCrossRefGoogle Scholar
  112. 112.
    Youdim, M. B. H., Green, A. R., and Grahame-Smith, D. G., 1977, Vth International Symposium on Parkinson’s Disease (W. Birkmayer and O. Hornykiewiz, eds.), Roche, Basel, pp. 127–135.Google Scholar
  113. 113.
    Ashkenazi, R., Ben-Shachar, D., and Youdim, M. B. H., 1982, Br. J. Pharmacol. 74:762–763.Google Scholar
  114. 113a.
    Ashkenazi, R., Ben-Shachar, D., and Youdim, M. B. H., 1982, Pharmacol. Biochem. Behav. 17:43–47.PubMedCrossRefGoogle Scholar
  115. 114.
    Youdim, M. B. H., Yehuda, S., and Ben-Uriah, Y., 1981, Eur. J. Pharmacol. 74:295–301.PubMedCrossRefGoogle Scholar
  116. 115.
    Becking, G. C., 1972, Biochem. Pharmacol. 21:1585–1594.PubMedCrossRefGoogle Scholar
  117. 116.
    Youdim, M. B. H., Green, A. R., and Aronson, J. K., 1977, Anaemia and Haematinics (R. G. Richardson, ed.), Abbott Laboratories Press, London, pp. 37–42.Google Scholar
  118. 117.
    Yehuda, S., and Wurtman, R. J., 1975, Eur. J. Pharmacol. 30:154–158.PubMedCrossRefGoogle Scholar
  119. 118.
    Yehuda, S., 1979, Commun. Psychopharmacol. 3:115–120.PubMedGoogle Scholar
  120. 119.
    Amit, T., Ben-Harari, R. R., and Youdim, M. B. H., 1981, Br. J. Pharmacol. 74:955–956P.Google Scholar
  121. 120.
    Barkey, R. J., Shani, J., Amit, T., and Youdim, M. B. H., 1981, Mol. Cell. Endocrinol. 21:129–138.PubMedCrossRefGoogle Scholar
  122. 121.
    Ashkenazi, R., Ben-Shachar, D., and Youdim, M. B. H., 1982, The Biochemistry and Physiology of Iron (P. Saltman and J. Hegenauer, eds.), Elsevier, Amsterdam, pp. 575–583.Google Scholar
  123. 122.
    Tucker, D. M., and Sandstead, H. H., 1981, Physiol. Behav. 26:439–449.PubMedCrossRefGoogle Scholar
  124. 123.
    Tucker, D. M., and Sandstead, H. H., 1982, Iron Deficiency, Brain Biochemistry and Behavior (E. Pollitt and R. L. Leibel, eds.), Raven Press, New York, pp. 161–181.Google Scholar
  125. 124.
    Iversen, S. D., 1977, Handbook of Psychopharmacology, Volume 8 (L. L. Iversen, S. D. Iversen, and S. H. Snyder, eds.), Plenum Press, New York, pp. 333–384.CrossRefGoogle Scholar
  126. 125.
    Margolin, D. I., 1978, J. Clin. Psychiatry 39:120–130.PubMedGoogle Scholar
  127. 126.
    Shaywitz, B. A., Yager, R. D., and Klopper, J. H., 1976, Science 194:305–308.CrossRefGoogle Scholar
  128. 127.
    Tucker, D. M., 1981, Psychol. Bull. 89:19–46.PubMedCrossRefGoogle Scholar
  129. 128.
    Weinberg, J., Dallman, P. R., and Levine, S., 1980, Pharmacol. Biochem. Behav. 12:493–502.PubMedCrossRefGoogle Scholar
  130. 129.
    Weinberg, J., Brett, L. P., Levine, S., and Dallman, P. R., 1981, Pharmacol. Biochem. Behav. 14:447–453.PubMedCrossRefGoogle Scholar
  131. 130.
    Massaro, T. F., 1982, Iron Deficiency, Brain Biochemistry and Behavior (E. Pollitt and R. L. Leibel, eds.), Raven Press, New York, pp. 125–140.Google Scholar
  132. 131.
    Youdim, M. B. H., Ben-Shachar, D., Ashkenazi, R., and Yehuda, S., 1983, CNS Receptors from Behavior to Pharmacology (P. Mandel and F. De Fredius, eds.), Raven Press, New York, pp. 309–331.Google Scholar
  133. 132.
    Glover, J., and Jacobs, A., 1972, Br. Med. J. 2:627–628.PubMedCrossRefGoogle Scholar
  134. 133.
    Yehuda, S., and Youdim, M. B. H., 1984, Eur. J. Pharmacol. (in press).Google Scholar
  135. 134.
    Youdim, M. B. H., Ben-Shachar, D., Ashkenazi, A., and Yehuda, S., 1984, 7th Parkinson s Disease Symposium, Raven Press, New York (in press).Google Scholar
  136. 135.
    Switzer, R. C., III, 1982, The Biochemistry and Physiology of Iron (P. Saltman and J. He-genauer, eds.), Elsevier, Amsterdam, pp. 569–575.Google Scholar
  137. 136.
    Meyer, A., 1958, Neuropathology (W. Blackwood, W. H. McMenemey, A. Meyer, and R. M. Norman, eds.), Arnold, London, pp. 525–537.Google Scholar
  138. 137.
    Dobling, E. C., Schoene, W. C., and Richardson, E. P., 1974, Arch. Neurol. 30:70–83.CrossRefGoogle Scholar
  139. 138.
    Vakili, S., Drew, A. L., Von Schuching, S., Becker, D., and Zeman, W., 1977, Arch. Neurol. 34:729–738.PubMedCrossRefGoogle Scholar
  140. 139.
    Borkey, R., Ben-Schachar, D., Amit, T., and Youdim, M. B. H., 1984, Eur. J. Pharmacol. (in press).Google Scholar
  141. 140.
    Szanto, J., and Gallyas, F., 1966, Arch. Neurol. 14:438–442.PubMedCrossRefGoogle Scholar
  142. 141.
    Sheldon, J. H., 1927, Q. J. Med. 21:123–127.CrossRefGoogle Scholar
  143. 142.
    Cammermeyer, J., 1947, J. Neuropathol. Exp. Neurol. 6:111–127.CrossRefGoogle Scholar
  144. 143.
    Klinworth, G. k., 1969, Progress in Neurogenetics (A. Barbeau and J. R. Brunette, eds.), Excerpta Medica, Amsterdam, pp. 589–596.Google Scholar
  145. 144.
    Klinworth, G. K., 1972, Adv. Neurol. 1:353–368.Google Scholar
  146. 145.
    Earle, K. M., 1968, J. Neuropathol. Exp. Neurol. 27:1–14.PubMedCrossRefGoogle Scholar
  147. 146.
    Barbeau, A., and Brunette, J. R., 1967, Progress in Neurogenetics (A. Barbeau and J. R. Brunette, eds.), Excerpta Medica, Amsterdam, pp. 509–682.Google Scholar
  148. 147.
    Riederer, P., Birkmayer, W., Jellinger, K., and Youdim, M. B. H., 1984, J. Neural. Transm. (in press).Google Scholar
  149. 148.
    Hsiang, N. S., 1941, J. Oriental Med. 33:119–162.Google Scholar
  150. 149.
    Strassman, G., 1945, J. Neuropathol. Exp. Neurol. 4:393–401.CrossRefGoogle Scholar
  151. 150.
    Rubin, J. J., and Willmore, L. J., 1980, Exp. Neurol. 67:472–480.PubMedCrossRefGoogle Scholar
  152. 151.
    Willmore, L. J., Hurd, R. W., and Sypert, G. W., 1978, Brain Res. 152:406–410.PubMedCrossRefGoogle Scholar
  153. 152.
    Willmore, L. J., Sypert, G. W., Munson, J. V., and Hurd, R. W., 1978, Science 200:1501–1503.PubMedCrossRefGoogle Scholar
  154. 153.
    Porter, R., and Elliot, K. C., (eds.), 1978, Oxygen, Free Radicals and Tissue Damage, Elsevier, Amsterdam.Google Scholar
  155. 154.
    Glover, J., and Jacobs, A., 1972, Br. Med. J. 2:627–628.PubMedCrossRefGoogle Scholar
  156. 155.
    Seeman, P., 1980, Pharmacol. Rev. 32:229–313.PubMedGoogle Scholar
  157. 156.
    Rajan, K. S., Manian, A. A., Davis, J. M., and Skriplus, A., 1974, Phenothiazines and Structurally Related Drugs (I. S. Forrest, C. J. Carr, and E. Usdin, eds.), Raven Press, New York, pp. 344–358.Google Scholar
  158. 157.
    Csernansky, J. G., Holman, C. A., Bonnet, K. A., Grabowski, K., King, R., and Hollister, L. E., 1982, Life Sci. 32:385–390.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • M. B. H. Youdim
    • 1
  1. 1.Department of PharmacologyRappaport Family Institute for Research in the Medical SciencesTechnion, HaifaIsrael

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