Neurochemical Aspects of Schizophrenia

  • Lynn Eleanor DeLisi
  • Richard Jed Wyatt


Schizophrenia, a syndrome characterized by delusions, hallucinations, and disturbances of thought, is one of the most pervasive and socially disabling of all psychiatric disorders. Approximately 27% of annual psychiatric hospital admissions (340,000) in the United States are patients with this disorder,1 and most individuals with a chronic schizophrenic illness, if not institutionalized, are unemployable and spend years in community care facilities. Despite the severe morbidity and relatively high prevalence of this disorder in the general population (approximately 1%),2 its etiology remains unknown. In the postwar years, schizophrenia research focused on putative psychodynamic and socioenvironmental vulnerabilities for development of this disorder. Severely disordered mother-infant relationships as well as pathological communication patterns among family members were, in some psychiatric circles, considered important environmental inducers of schizophrenia. Terms such as “schizophrenigenic mother,”3 “double bind,” and “schism”4,5 were used to describe these pathological relationships. There is no doubt that disturbed relationships within some, but no all, families of schizophrenics are accurate observations, although how these stressors are associated with the etiology of schizophrenia remains obscure. Nevertheless, decreasing familial and other social stresses has been demonstrated to be an extremely important treatment strategy.6


Schizophrenic Patient Fusaric Acid Schizophrenic Symptom Neuroleptic Medication Chronic Schizophrenic Patient 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Lynn Eleanor DeLisi
    • 1
  • Richard Jed Wyatt
    • 2
  1. 1.Neurogenetics Branch, Intramural Research ProgramNational Institute of Mental HealthBethesdaUSA
  2. 2.Neuropsychiatry Branch, Intramural Research Program, National Institute of Mental HealthSaint Elizabeths HospitalUSA

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