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Pathological Neurochemistry of Cerebrospinal Fluid

Neurotransmitters and Neuropeptides

  • Chapter
Pathological Neurochemistry

Abstract

Measurement of neuroactive substances in human cerebrospinal fluid (CSF) offers a unique opportunity for elucidating the pathology of neuropsychiatric disorders as well as for evaluating therapeutic approaches to these disorders. Human CSF is readily available and, in fact, offers the only source of such information from living patients that does not require brain biopsy with its associated morbidity. Studies of CSF effectively circumvent vagaries associated with extrapolation of data from autopsy tissue or from imperfect animal models.

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Authors and Affiliations

  1. Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA

    Theodore A. Hare

  2. Cerebral Blood Flow Laboratories, Division of Neurosurgery, Emory University Clinic, Atlanta, Georgia, 30322, USA

    James H. Wood

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  1. Theodore A. Hare
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  1. Center for Neurochemistry, Wards Island, New York, USA

    Abel Lajtha

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Hare, T.A., Wood, J.H. (1985). Pathological Neurochemistry of Cerebrospinal Fluid. In: Lajtha, A. (eds) Pathological Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0797-7_16

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