Multiple Sclerosis

  • Jørgen Clausen


The term “demyelinating disease” is conventionally given to a group of diseases of the central nervous system (CNS) characterized by focal or diffuse areas of demyelination and neuroglial sclerosis, usually unrelated to tracts and fiber systems. Demyelination is of two types, the so-called primary demyelination and secondary demyelination. The primary demyelinating diseases are multiple sclerosis (MS), Schilder’s diffuse cerebral sclerosis, post- and parainfectious encephalomyelitis, postvaccinal and vaccine encephalomyelitis, acute necrotizing hemorrhagic leukoencephalitis, subacute combined degeneration, central pontine myelinoclasis, Marchiafava-Bignani syndrome, and progressive multifocal leukoencephalopathy. A characteristic finding in primary demyelination is that the myelin sheets disintegrate initially, leaving the axon intact.


Multiple Sclerosis Multiple Sclerosis Patient Measle Virus Experimental Allergic Encephalomyelitis Oligoclonal Band 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Waller, A. V., 1850, Phil. Trans. R. Soc. 1:423.CrossRefGoogle Scholar
  2. 2.
    Cruveillier, J., 1835–42, Atlas ď Anatomie Pathologique du Corps Humain 2, Baillière, Paris.Google Scholar
  3. 3.
    Carswell, R., 1838, Pathological Anatomy, Illustrations of the Elementary Forms of Disease, London.Google Scholar
  4. 4.
    Valentiner, W., 1856, Dtsch. Klin. 8:147.Google Scholar
  5. 5.
    Rindfleisch, 1863, Virchows Arch. 26:474.CrossRefGoogle Scholar
  6. 6.
    Charcot, J. M., 1868, Gaz. Hop. (Paris) 41:554,557, 566.Google Scholar
  7. 7.
    Kurtzke, J. F., 1970, Acta Neurol. Scand. 46:484–492.PubMedCrossRefGoogle Scholar
  8. 8.
    McAlpine, D., 1973, Br. Med. J. 2:292–295.PubMedCrossRefGoogle Scholar
  9. 9.
    Parinaud, H., 1884, Prog. Med. (Paris) 12:641.Google Scholar
  10. 10.
    Hyllested, K., 1950, Ugeskrift Laeger 112:853–866.Google Scholar
  11. 11.
    Fog, T., and Linnemann, F., 1970, Acta Neurol. Scand. [Suppl.] 47:1–175.Google Scholar
  12. 12.
    Regan, D., Milner, B. A., and Heron, J. R., 1976, Brain 99:43–66.PubMedCrossRefGoogle Scholar
  13. 13.
    Maurer, K., Schäfer, E., Hopf, H. C., and Leitner, H., 1980, J. Neurol. 223:43–58.PubMedCrossRefGoogle Scholar
  14. 14.
    Eisen, A., Stewart, J., Nuddleman, K., and Cosgrove, J. B. R., 1979, Neurology (Minneap.) 29:827–834.CrossRefGoogle Scholar
  15. 15.
    Ludwin, S. K., 1981, Adv. Neurol. 31:123–168.PubMedGoogle Scholar
  16. 16.
    Bartlett, P. F., and Mackay, I. R., 1983, J. Clin. Lab. Immunol. 11:1–7.PubMedGoogle Scholar
  17. 17.
    Bielschowsky, M., 1903, Neurol. Zentralbl. 22:770.Google Scholar
  18. 18.
    King, L. S., 1937, Arch. Pathol. 23:338.Google Scholar
  19. 19.
    Itoyama, Y., Webster, H., Richardson, E. P., and Trapp, B. D., 1983, Ann. Neurol. 14:339–346.PubMedCrossRefGoogle Scholar
  20. 20.
    Peters, G., 1936, Z. Ges. Neurol. Psychiatrie 155:178.CrossRefGoogle Scholar
  21. 21.
    Fog, T., 1965, Acta Neurol. Scand. (Suppl) 15:41.Google Scholar
  22. 21a.
    Adams, C. V., 1977, Br. Med. Bull. 33:15–20.PubMedGoogle Scholar
  23. 22.
    Weiner, L. P., 1973, Arch. Neurol. 28:298–303.PubMedCrossRefGoogle Scholar
  24. 23.
    Prineas, J. W., and Raine, C. S., 1976, Neurology (Minneap.) 26(2):29–32.CrossRefGoogle Scholar
  25. 24.
    Prineas, J. W., and Connell, F., 1978, Neurology (Minneap.) 28(2):68–75.CrossRefGoogle Scholar
  26. 25.
    Lampert, P. W., 1978, Am. J. Pathol. 91:175–208.Google Scholar
  27. 26.
    Dal Canto, M. C., Wisniewski, H. M., and Johnson, A. B., 1975, J. Neurol. Sci. 24:313–319.CrossRefGoogle Scholar
  28. 27.
    Kirk, J., 1979, Neuropathol. Appl. Neurobiol. 5:289–294.PubMedCrossRefGoogle Scholar
  29. 28.
    Prineas, J., 1972, Science 178:760–763.PubMedCrossRefGoogle Scholar
  30. 29.
    Ter Meulen V., Koprowski, H., Iwasaki, Y., Käckell, Y. M., and Müller, D., 1972, Lancet 2:1–5.PubMedCrossRefGoogle Scholar
  31. 30.
    Field, E. J., Cowshall, S., Narang, H. K., and Bell, T. M., 1972, Lancet 2:280–281.PubMedCrossRefGoogle Scholar
  32. 31.
    Barbosa, L. H., and Hamilton, R., 1973, Lancet 1:1415–1417.PubMedCrossRefGoogle Scholar
  33. 32.
    Lewandowski, L. J., Lief, F. S., Verini, M. A., Pienkowski, M. M., Ter Meulen, V., and Koprowski, H., 1974, J. Virol. 13:1037–1045.PubMedGoogle Scholar
  34. 33.
    Carp, R. I., Licursi, P. C., Merz, P. A., and Merz, G. S., 1972, J. Exp. Med. 136:618.PubMedCrossRefGoogle Scholar
  35. 34.
    Pathak, S., and Webb, H. E., 1976, Lancet 2:311.PubMedCrossRefGoogle Scholar
  36. 35.
    Woyciechowska, J. L., Madden, D. L., and Sever, J. L., 1977, Lancet 2:1046–1049.PubMedCrossRefGoogle Scholar
  37. 36.
    Mitchell, D. N., Porterfield, J. S., Micheletti, R., Lange, L. S., Goswami, K. K. A., Taylor, P., Jacobs, J. P., Hockley, D. J., and Salsbury, A. J., 1978, Lancet 2:387–391.PubMedCrossRefGoogle Scholar
  38. 37.
    Cobill, J. M., Hugehes, D., Keith, A. B., Cameron, K. R., Mason, J., and Caspary, E. A., 1979, J. Neurol. Sci. 41:11–16.PubMedCrossRefGoogle Scholar
  39. 38.
    Burks, J. S., DeVald, B. L., Jankovsky, L. D., and Gerdes, J. C., 1980, Science 209:933–934.PubMedCrossRefGoogle Scholar
  40. 39.
    Raine, C. S., Powers, J. M., and Suzuki, 1974, Arch. Neurol. 30:39–46.PubMedCrossRefGoogle Scholar
  41. 40.
    Lipton, H. L., and Dal Canto, M. C., 1976, J. Neurol. Sci. 30:201–207.PubMedCrossRefGoogle Scholar
  42. 41.
    Adams, C. W. M., 1965, Neurohistochemistry, Elsevier, Amsterdam.Google Scholar
  43. 42.
    Abercrombie, M., and Johnson, M. L., 1946, J. Neurol. Neurosurg. Psychiatry 9:113.PubMedCrossRefGoogle Scholar
  44. 43.
    Rastogi, S. C., and Clausen, J., 1980, Clin. Exp. Immunol. 42:50–56.PubMedGoogle Scholar
  45. 44.
    Rossiter, R. J., 1965, Neurochemistry (K. A. C. Elliott, I. H. Page, and J. H. Qastel, eds.), Charles C Thomas, Springfield, Illinois, p. 696.Google Scholar
  46. 45.
    Prineas, J. W., 1979, Science 203:1123–1125.PubMedCrossRefGoogle Scholar
  47. 46.
    Alter, M., Liebowitz, U., and Speer, J., 1966, Arch. Neurol. 15:234–237.PubMedCrossRefGoogle Scholar
  48. 47.
    Leibowitz, U., Halpern, L., and Alter, M., 1964, Arch. Neurol. 10:502–512.PubMedCrossRefGoogle Scholar
  49. 48.
    Dean, G., 1972, Multiple Sclerosis, Progress in Research (E. J. Field, T. M. Bell, and P. R. Carnegie, eds.), North-Holland, Amsterdam, London, pp. 196–203.Google Scholar
  50. 49.
    Acheson, E. D., 1972, Multiple Sclerosis: A Reappraisal, 2nd ed. (D. McAlpine, C.E. Lumsden, and E. D. Acheson, eds.), Churchill Livingstone, Edinburgh, pp. 22.Google Scholar
  51. 50. F.
    Kurtzke, J., 1972, Multiple Sclerosis, Progress in Research (E. J. Field, T. M. Bell, and P. R. Carnegie, eds.), North-Holland, Amsterdam, London, pp. 208–228.Google Scholar
  52. 51.
    Acheson, E. D., 1977, Br. Med. Bull. 33:9–14.PubMedGoogle Scholar
  53. 52.
    Kurtzke, J. F., and Kurland, L. T., 1973, Clinical Neurology, Volume 3 (A. B. Baker and L. H. Baker, eds.), Harper and Row, New York. pp. 1–80.Google Scholar
  54. 53.
    Kurtzke, J. F., 1980, Neurology (N.Y.) 30:61–79.CrossRefGoogle Scholar
  55. 54.
    Kurtzke, J. F., and Hyllested, K., 1979, Ann. Neurol. 5:6–21.PubMedCrossRefGoogle Scholar
  56. 55.
    Poskanzer, C. D., Walker, A. M., Prenney, L. B., and Sheridan, J. L., 1981, Neurology (N.Y.) 31:708–713.CrossRefGoogle Scholar
  57. 56.
    Gudmundsson, K. R., 1971, Acta Neurol. Scand. (Suppl.)48:47.Google Scholar
  58. 57.
    Isager, H., Larsen, S., and Hyllested, K., 1980, Int. J. Epidemiol. 9:145–147.PubMedCrossRefGoogle Scholar
  59. 58.
    Jersild, C., Ammitzboll, T., Clausen, J., and Fog, T., 1973, Lancet 1:151–152.PubMedCrossRefGoogle Scholar
  60. 59.
    Jersild, C., 1978, The HLA System and Multiple Sclerosis, The National Foundation, Alan R. Liss, New York.Google Scholar
  61. 60.
    Pathy, D. W., Mervart, H., Campling, B., Rand, C. G., and Stiller, C. R., 1974, Can. J. Neurol. Sci. 1:211–213.Google Scholar
  62. 61.
    Svejgaard, A., Hauge, M., Jersild, C., Platz, P., Ryder, L. P., Nielsen, L. S., and Thomsen, M., 1975, Monographs in Human Genetics, The HLA System, Volume 7 (L. Beckman and M. Hauge, eds.) S. Karger, Basel.Google Scholar
  63. 61a.
    Lewin, R., 1975, Laboratoriumsblatter 1:1.Google Scholar
  64. 62.
    Terasaki, P. I., and Mickey, M. R., 1976, Neurology (Minneap.) 26:56–58.CrossRefGoogle Scholar
  65. 63.
    Haile, R. W., Hodge, S. E., Visscher, B. R., Spence, M. A., Detels, R., McAuliffe, T. L., Park, M. S., and Dudley, J. P., 1980, Clin. Genet. 18:160–167.PubMedCrossRefGoogle Scholar
  66. 64.
    Drachman, D. A., Davison, W. C., and Mittal, K. K., 1976, Arch. Neurol. 33:406–413.PubMedCrossRefGoogle Scholar
  67. 65.
    Sigurdsson, B., 1954, Br. Vet. J. 110:341–354.Google Scholar
  68. 66.
    Cook, S. D., and Dowling, P. C., 1980, Neurology (N.Y.] 30(2):80–91.CrossRefGoogle Scholar
  69. 67.
    Adams, J. M., and Imagawa, D. T., 1962, Proc. Soc. Exp. Biol. Med. 111:562–566.PubMedGoogle Scholar
  70. 68.
    Panelius, M., 1969, Acta Neurol. Scand. [Suppl.] 39:45.Google Scholar
  71. 69.
    Ammitzboll, T., and Calusen, J., 1972, Acta Neurol. Scand. 48:47–56.PubMedCrossRefGoogle Scholar
  72. 70.
    Salmi, A., Panelius, M., and Vainiopää, R., 1974, Acta Neurol. Scand. 50:183–193.PubMedCrossRefGoogle Scholar
  73. 71.
    Beck, H. W., and Clausen, J., 1977, Zentralbl. Bakteriol. Hyg. [Orig. A] 338:431–443.Google Scholar
  74. 72.
    Haase, A. T., Ventura, P., and Tourtelotte, W. W., 1981, Science 212:672–674.PubMedCrossRefGoogle Scholar
  75. 73.
    Ammitzboll, T., Offner, H., Clausen, J., Kobayasi, T., Asboe-Hansen, G., Hyllested, K., and Fog, T., 1976, Acta Neurol. Scand. 53:137–151.PubMedCrossRefGoogle Scholar
  76. 74.
    Whitaker, J. N., Herrmann, K. L., Rogentine, G. N., Stein, S. F., and Kollins, L. L., 1976, Arch. Neurol. 33:399–403.PubMedCrossRefGoogle Scholar
  77. 75.
    Kurtzke, J. F., and Priester, W. A., 1979, Acta Neurol. Scand. 60:312–319.PubMedCrossRefGoogle Scholar
  78. 76.
    Krakowka, S., and Koestner, A., 1978, Lancet 1:1127–1128.PubMedCrossRefGoogle Scholar
  79. 77.
    Johnson, K. P., Likosky, W. H., Nelson, B. J., and Fein, G., 1980, Arch. Neurol. 37:537–541.PubMedCrossRefGoogle Scholar
  80. 78.
    Cremer, N. E., Johnson, K. P., Fein, G., and Likosky, W. H., 1980, Arch. Neurol. 37:610–615.PubMedCrossRefGoogle Scholar
  81. 79.
    Forghani, B., Cremer, N. E., Johnson, K. P., Fein, G., and Likosky, W. H., 1980, Arch. Neurol. 37:616–619.PubMedCrossRefGoogle Scholar
  82. 80.
    Szekeres, J., Palffy, Gy., and Paradi, J., 1980, Lancet 2:1089–1090.PubMedCrossRefGoogle Scholar
  83. 81.
    Martin, J. R., 1981, Lancet 2:777–781.PubMedCrossRefGoogle Scholar
  84. 82.
    Fraser, K. B., 1977, Br. Med. Bull. 33:34–39.PubMedGoogle Scholar
  85. 83.
    McAlpine, D., Lumsden, C. E., and Acheson, E. D., 1965, Multiple Sclerosis, A Reappraisal, E. and S. Livingstone, Edinburgh.Google Scholar
  86. 84.
    Friede, R. L., 1966, Topographic Brain Chemistry, Academic Press, New York, London.Google Scholar
  87. 85.
    McKeown, S. R., and Allen, I. V., 1979, Neuropathology 5:405–415.Google Scholar
  88. 86.
    Yahara, S., Kawamura, N., Kishimoro, Y., Saida, T., and Tourtelotte, W. W., 1982, J. Neurol. Sci. 54:303–315.PubMedCrossRefGoogle Scholar
  89. 87.
    Swank, R. L., 1953, Arch. Neurol. Psychiatry. 69:91–103.CrossRefGoogle Scholar
  90. 88.
    Agranoff, B. W., and Goldberg, D., 1974, Lancet 2:1061.PubMedCrossRefGoogle Scholar
  91. 89.
    Mertin, J., and Meade, C. J., 1977, Br. Med. Bull. 33:67–71.PubMedGoogle Scholar
  92. 90.
    Cumings, J. N., Shortman, R. C., and Skibic, T., 1965, J. Clin. Pathol. 18:641–644.PubMedCrossRefGoogle Scholar
  93. 91.
    Gerstl, B., Eng, L. F., Tavaststjerna, M. G., Smith, J. K., and Kruse, S. L., 1970, J. Neurochem. 17:677–689.PubMedCrossRefGoogle Scholar
  94. 92.
    Thompson, R. H. S., 1966, Proc. R. Soc. Med. 59:269–276.PubMedGoogle Scholar
  95. 93.
    Clausen, J., and Hansen, I. B., 1970, Acta Neurol. Scand. 46:1–17.PubMedCrossRefGoogle Scholar
  96. 94.
    Clausen, J., and Møller, J., 1967, Acta Neurol. Scand. 43:375–388.PubMedCrossRefGoogle Scholar
  97. 95.
    Baker, R. W. R., Thompson, R. H. S., and Zilka, K. J., 1966, J. Neurol. Neurosurg. Psychiatry 29:95–98.CrossRefGoogle Scholar
  98. 96.
    Wolfram, G., Eckhart, J., and Zöllner, N., 1977, Nutr. Metab. 21(Suppl. 1):127–129.PubMedCrossRefGoogle Scholar
  99. 97.
    Yoshida, M., Takase, S., Itahara, K., and Nakanishi, T., 1983, Acta Neurol. Scand. 68:362–364.PubMedCrossRefGoogle Scholar
  100. 98.
    Wolfgram, F., Myers, L., Ellison, G., and Knipprath, W., 1975, Neurology (Minneap.) 25:766–768.CrossRefGoogle Scholar
  101. 99.
    Heipertz, R., Klauke, W., Pilz, H., and Ritter, G., 1977, J. Neurol. 214:153–157.PubMedCrossRefGoogle Scholar
  102. 100.
    Callaghan, N. C., Kearney, B., and Love, W. C., 1973, J. Neurol. Neurosurg. Psychiatry 36:668–673.PubMedCrossRefGoogle Scholar
  103. 101.
    Love, W. C., Cashell, A., Reynolds, M., and Callaghan, N., 1974, Br. Med. J. 462:18–21.CrossRefGoogle Scholar
  104. 102.
    Cummings, J. N., and Goodwin, H., 1968, Lancet 2:664.CrossRefGoogle Scholar
  105. 103.
    Norton, W. T., 1981, Demyelinating Disease: Basic and Clinical Electrophysiology (S. G. Waxman and J. M. Richie, eds.), Raven Press, New York, pp. 93–121.Google Scholar
  106. 104.
    Rhein, L. D., and Sampugna, J., 1981, Lipids 7:502–507.CrossRefGoogle Scholar
  107. 105.
    Woelk, H., and Borri, P., 1973, Eur. Neurol. 10:250.PubMedCrossRefGoogle Scholar
  108. 106.
    Wolfgram, F., 1972, Chemical Theories of the Demyelination in Multiple Sclerosis, Immunology, Virology and Ultrastructure (F. Wolfgram, G. W. Ellison, J. G. Stevens, and J. M. Andrews, eds.), Academic Press, New York, pp. 172–182.Google Scholar
  109. 107.
    Suzuki, K., Kamoshita, S. Eto, Y., Tourtelotte, W. W., and Gonatas, J. O., 1973, Arch. Neurol. 28:293–297.PubMedCrossRefGoogle Scholar
  110. 108.
    Yu, R. K., Ueno, K. Glaser, G. H., and Tourtelotte, W., 1982, J. Neurochem. 39:464–477.PubMedCrossRefGoogle Scholar
  111. 109.
    McKhann, M., 1982, Annu. Rev. Neurosci. 5:219–239.PubMedCrossRefGoogle Scholar
  112. 110.
    Riekkinen, P. R., Palo, J., Arstila, A. U., Savolainen, H. J., Rinne, U. K., Kivalo, E. K., and Frey, H., 1971, Arch. Neurol. 24:545.PubMedCrossRefGoogle Scholar
  113. 111.
    Wolfgram, F., and Tourtelotte, W. W., 1972, Neurology (Minneap.) 22:1044.CrossRefGoogle Scholar
  114. 112.
    Eng, L. F., Chao, F.-C., Gerstl, B., Pratt, D., and Travastsjema, M. G., 1968, Biochemistry 7:4455.PubMedCrossRefGoogle Scholar
  115. 113.
    Riekkinen, P. J., Clausen, J., Frey, H. J., Fog, T., and Rinne, U. K., 1970, Acta Neurol. Scand. 3:349–353.CrossRefGoogle Scholar
  116. 114.
    Cuzner, M. L., Bernard, R. O., McGregor, B. J. L., Borshell, N. J., and Davison, A. N., 1976, J. Neurol. Sci. 29:323–334.PubMedCrossRefGoogle Scholar
  117. 115.
    Sachs, H., and Steiner, G., 1934, Klin. Sochenschr. 13:1714.CrossRefGoogle Scholar
  118. 116.
    Roemer, G. B., and Mai, K., 1967, Z. Immun. Allg. Klin. Immunol. 134:370–390.Google Scholar
  119. 117.
    Clausen, J., Fog, T., Offner, H., and Rastogi, S. C., 1978, Acta Neurol. Scand. 57(Suppl. 67):247–248.Google Scholar
  120. 118.
    Rastogi, S. C., Clausen, J., Offner, H., Konat, G., and Fog, T., 1979, Acta Neurol. Scand. 59:281–296.PubMedCrossRefGoogle Scholar
  121. 119.
    Rastogi, S. C., and Clausen, J., 1980, Clin. Chim. Acta 101:85–92.PubMedCrossRefGoogle Scholar
  122. 120.
    Rastogi, S. C., Clausen, J., and Tourtelotte, W. W., 1983, Eur. Neurol. 22:17–21.PubMedCrossRefGoogle Scholar
  123. 121.
    Clausen, J., 1983, J. Neurol. Sci. 60:205–216.PubMedCrossRefGoogle Scholar
  124. 122.
    Hukkanen, V., Salmi, A., and Frey, H., 1982, J. Neuroimmunol. 3:295–305.PubMedCrossRefGoogle Scholar
  125. 123.
    Hashim, G. A., Lee, D. M., Pierce, J. C., Braun, C. W., and Fitzpatrick, H. F., 1978, Neurochem. Res. 3:37–48.PubMedCrossRefGoogle Scholar
  126. 124.
    Offner, H., Konat, G., Legg, N. J., Raun, N. E., Winterberg, H., and Clausen, J., 1980, Immunopathology 16:367–373.CrossRefGoogle Scholar
  127. 125.
    Offner, H., Rastogi, S. C., Konat, G., and Clausen, J., 1979, J. Neurol. Sci. 42:349–355.Google Scholar
  128. 126.
    Offner, H., Fog, T., Rastogi, S. C., Konat, G., and Clausen, J., 1979, Acta Neurol. Scand. 59:49–54.PubMedCrossRefGoogle Scholar
  129. 127.
    Turner, A., Cuzner, M. L., Davison, A. N., and Rudge, P., 1980, J. Neurol. Neurosurg. Psychiatry 43:305–309.PubMedCrossRefGoogle Scholar
  130. 128.
    Rastogi, S. C., and Clausen, J., 1980, Clin. Exp. Immunol. 42:50–56.PubMedGoogle Scholar
  131. 129.
    Rastogi, S. C., and Clausen, J., 1982, Acta Neurol. Scand. 67:218–221.CrossRefGoogle Scholar
  132. 130.
    Kabat, E. A., Moore, D. H., and Landow, H., 1942, J. Clin. Invest. 21:571.PubMedCrossRefGoogle Scholar
  133. 131.
    Löwenthal, A., v. Sande, M., and Karcher, D., 1960, J. Neurochem. 6:51–56.CrossRefGoogle Scholar
  134. 132.
    Clausen, J., Matzke, J., and Gerhardt, W., 1964, Acta Neurol. Scand. 40(Suppl. 10]:49–56.CrossRefGoogle Scholar
  135. 133.
    Link, H., 1967, Acta Neurol. Scand 43(Suppl. 28]:1–136.PubMedGoogle Scholar
  136. 134.
    Christensen, O., Clausen, J., and Fog, T., 1978, J. Neurol. 218:237–244.PubMedCrossRefGoogle Scholar
  137. 135.
    Laurenzi, M. A., 1981, Immunochemical Characterization of Immunoglobulins and Viral Antibodies Synthesized within the Central Nervous System in Patients with Multiple Sclerosis and Controls, Linköping University Medical Dissertation, Linköping.Google Scholar
  138. 136.
    Hosein, Z. Z., and Johnson, K. P., 1981, Neurology (N.Y.) 31:70–76.CrossRefGoogle Scholar
  139. 137.
    Schuller, E., 1981, Les Proteines du Liquide Céphalo-Rachidien et les Maladies Immunitaires du Systeme Nerveux, Hoechst-Behring, Paris.Google Scholar
  140. 138.
    Kempe, C. H., Takabayashi, K., Miyamoto, H., Mcintosh, K., Tourtellotte, W. W., and Adams, J. M., 1973, Arch. Neurol. 28:278–279.PubMedCrossRefGoogle Scholar
  141. 139.
    Roström, B., 1981, Acta Neurol. Scand. 86[Suppl.]:63.Google Scholar
  142. 140.
    Nordal, H. J., Vandvik, B., and Norrby, E., 1978, Scand. J. Immunol. 7:473–479.PubMedCrossRefGoogle Scholar
  143. 141.
    Mattson, D. H., Ross, R. P., and Arnason, B. G. W., 1980, Nature 287:335–337.PubMedCrossRefGoogle Scholar
  144. 142.
    Sandberg-Wollheim, M., 1975, Studies on Immunoglobulin Synthesis and Lymphocyte Subpopulations in the Cerebrospinal Fluid, Grafo Tryk, Malmö.Google Scholar
  145. 143.
    Nakao, A., Davis, W. J., and Einstein, E. R., 1966, Biochim. Biophys. Acta. 130:163–171.CrossRefGoogle Scholar
  146. 144.
    Govindarajan, K. R., Rauch, H. C., Clausen, J., and Einstein, E. R., 1974, J. Neurol. Sci. 23:295–306.PubMedCrossRefGoogle Scholar
  147. 145.
    Traugott, U., Schevach, E., Chiba, J., Stone, J. H., and Raine, C. S., 1981, Science 214:1251–1252.PubMedCrossRefGoogle Scholar
  148. 146.
    Ammitzbøll, T., Clausen, J., and Fog, T., 1977, Acta Neurol. Scand. 56:153–158.PubMedCrossRefGoogle Scholar
  149. 147.
    Kam-Hansen, S., 1980, Distribution and Function of Lymphocytes from the Cerebrospinal Fluid and Blood in Patients with Multiple Sclerosis, Linköping University, Linköping.Google Scholar
  150. 148.
    Coyle, P. K., Brooks, B. R., Hirsch, R. L., Cohen, S. R., O’Donnell, P., Johnson, R. T., and Wolinsky, J. S., 1980, Lancet 2:229–232.PubMedCrossRefGoogle Scholar
  151. 149.
    Roström, B., and Link, H., 1981, Neurology (N.Y.) 31:590–596.CrossRefGoogle Scholar
  152. 150.
    Clausen, J., 1966, Acta Neurol. Scand. 42:153–160.PubMedCrossRefGoogle Scholar
  153. 151.
    Clausen, J., and Fog, T., 1969, Pathogenesis and Etiology of Demyelinating Diseases, S. Karger, Basel, pp. 648–656.Google Scholar
  154. 152.
    Nagai, Y., Sakakibara, K., and Uchida, T., 1979, Immunomodulatory Roles of Gangliosides in EAE and EAN, Hertie Foundation, Frankfurt/Main.Google Scholar
  155. 153.
    Traugott, U., and Raine, C. S., 1981, Neurology (N.Y.) 31:695–700.CrossRefGoogle Scholar
  156. 154.
    Sheremata, W., Eylar, E. H., and Cosgrove, J. B. R., 1977, J. Neurol. Sci. 32:255–263.PubMedCrossRefGoogle Scholar
  157. 155.
    Arnon, R., Crisp, E., Kelley, R., Ellison, G. W., Myers, L. W., and Tourtellotte, W. W., 1980, J. Neurol. Sci. 46:179–186.PubMedCrossRefGoogle Scholar
  158. 156.
    Nordal, H. J., and Vandvik, B., 1977, Scand. J. Immunol. 6:327–334.PubMedCrossRefGoogle Scholar
  159. 157.
    Bernard, C. C. A., Randell, V. B., Horvath, L. B., Carnegie, P. R., and Mackay, I. R., 1981, Immunology 43:447–457.PubMedGoogle Scholar
  160. 158.
    Gerhard, W. A., Taylor, Z., Wroblewska, M., Sandberg-Wollheim, M., and Koprowski, H., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:3225–3229.PubMedCrossRefGoogle Scholar
  161. 159.
    Nagelkerken, L. M., Aalberse, B. C., Walbeek, H. K., and Out, T. A., 1980, J. Immunol. 125:384–389.PubMedGoogle Scholar
  162. 160.
    Ryberg, B., 1981, Studies on Complement-Fixing Antibrain Antibodies in Multiple Sclerosis, Infotryk, Malmö.Google Scholar
  163. 161.
    Broman, T., 1947, Acta Psychiatr. Neurol. 46:58–71.CrossRefGoogle Scholar
  164. 162.
    Lisak, R. P., Levinson, A. I., Zweiman, B., and Abdou, N. I., 1975, Clin. Exp. Immunol. 22:30–34.PubMedGoogle Scholar
  165. 163.
    Arnason, B. G. W., and Antel, J. P., 1978, Ann. Immunol. 129C:159–170.Google Scholar
  166. 164.
    Traugott, U., Scheinberg, L. C., and Raine, C. S., 1981, Ann. Neurol. 11:182–186.CrossRefGoogle Scholar
  167. 165.
    Dropcho, E. J., Richman, D. P., Antel, J. P., and Arnason, B. G. W., 1978, Fed. Proc. 37:1764.Google Scholar
  168. 166.
    Booss, J., and Dwyer, J. M., 1979, Neurology (Minneap.) 29:537.Google Scholar
  169. 167.
    Antel, J. P., and Weinrich, M., and Arnason, B. G. W., 1978, Neurology (Minneap.) 28:993–1003.Google Scholar
  170. 168.
    Gonzalez, R. L., Dau, P. C., and Spitler, L. E., 1979, Clin. Exp. Immunol. 36:78–84.PubMedGoogle Scholar
  171. 169.
    Offner, H., 1976, Studies on Pathogenic Factors in Multiple Sclerosis, Thesis, Fossum, Birkerød, Denmark.Google Scholar
  172. 170.
    McFarland, H. F., and McFarlin, D. E., 1979, Ann. Neurol. 6:101–106.PubMedCrossRefGoogle Scholar
  173. 171.
    Schauf, V., Schauf, C. L., Mizen, M., and Davis, F. A., 1981, Acta Neuroi. Scand. 64:383–393.CrossRefGoogle Scholar
  174. 172.
    Neighbor, P. A., and Bloom, B. R., 1979, Proc. Natl. Acad. Sci. U.S.A. 76:476–480.CrossRefGoogle Scholar
  175. 173.
    Pichler, W. J., and Broder, S., 1981, Immunol. Rev. 56:163–197.PubMedCrossRefGoogle Scholar
  176. 174.
    Goust, J. M., Chenais, F., Carnes, J. E., Harnes, C. G., Fudenberg, H. H., and Hogan, E. L., 1978, Neurology (Minneap.) 28:421–425.CrossRefGoogle Scholar
  177. 175.
    Huddlestone, J. R., and Oldstone, M. B. A., 1979, J. Immunol. 123:1615–1618.PubMedGoogle Scholar
  178. 176.
    Dore-Duffy, P. Zurier, R. B., Donaldson, J., Nystrom, S. S., Viola, M. V., Rothman, B., and Thompson, H. G., 1979, Neurology (Minneap.) 29:232–235.CrossRefGoogle Scholar
  179. 177.
    Frey, H., Salmi, A., and Svedström, E., 1979, J. Neurol. 220:99–104.PubMedCrossRefGoogle Scholar
  180. 178.
    Kinnman, J., and Link, H., 1979, Acta Neurol. Scand. 59:241–247.PubMedCrossRefGoogle Scholar
  181. 179.
    Davison, A. N., and Ilyas, A. A., 1982, Int. Arch. Allergy Appl. Immunol. 69:393–396.PubMedCrossRefGoogle Scholar
  182. 180.
    Colby-Germinario, S. P., Sheremata, W., Bain, B., and Eylar, E. H., 1977, J. Neurol. Sci. 33:111–129.PubMedCrossRefGoogle Scholar
  183. 181.
    Mar, P., Gradl, T., and Dörner, C., 1979, J. Neurol. Sci. 41:369–377.PubMedCrossRefGoogle Scholar
  184. 182.
    Frick, E., and Stickl, H., 1980, J. Neurol. Sci. 46:187–197.PubMedCrossRefGoogle Scholar
  185. 183.
    Santoli, D., Hall, W., Kastrukoff, L., Lisak, R. P., Rerussia, B., Trinchieri, G., and Koprowski, H., 1981, J. Immunol. 126:1274–1278.PubMedGoogle Scholar
  186. 184.
    Mar, P., 1980, J. Neurol. Sci. 47:285–303.PubMedCrossRefGoogle Scholar
  187. 185.
    Rastogi, S. C., Clausen, J., and Fog, T., 1981, Eur. Neurol. 20:33–39.PubMedCrossRefGoogle Scholar
  188. 186.
    Rastogi, S. C., and Clausen, J., 1980, Clin. Chim. Acta 107:141–144.PubMedCrossRefGoogle Scholar
  189. 187.
    Swank, R. L., 1955, Arch. Neurol. Psychiatry 73:631–644.CrossRefGoogle Scholar
  190. 188.
    Swank, R. L., 1956, Ann. Intern. Med. 45:812–824.PubMedGoogle Scholar
  191. 189.
    Schauf, C. L., Frischer, H., and Davis F. A., 1980, Neurology (N.Y.) 30:323–325.CrossRefGoogle Scholar
  192. 190.
    Neu, I. S., Prosiegel, M., and Pfaffenrath, V., 1982, Acta Neurol. Scand. 66:497–504.PubMedCrossRefGoogle Scholar
  193. 191.
    Shukla, V. K. S., Jensen, G. E., and Clausen, J., 1977, Acta Neurol. Scand. 56:542–550.PubMedCrossRefGoogle Scholar
  194. 192.
    Jensen, G. E., Gissel-Nielsen, G., and Clausen, J., 1980, J. Neurol. Sci. 48:61–67.PubMedCrossRefGoogle Scholar
  195. 193.
    Szeinberg, A., Golan, R., Ben-Ezzer, J., Sarova-Pinhas, I., and Kindler, D., 1981, Acta Neurol. Scand. 63:67–75.PubMedCrossRefGoogle Scholar
  196. 194.
    Jensen, G. E., and Clausen, J., 1984, J. Neurol. Sci. 63:45–53.PubMedCrossRefGoogle Scholar
  197. 195.
    Srivastava, K. C., Fog, T., and Clausen, J., 1975, Acta Neurol. Scand. 51:193–199.CrossRefGoogle Scholar
  198. 196.
    Flohé, L., Günzler, W. A., and Ladenstein, R., 1976, Kroc Foundation Glutathione: Metabolism and Function (I. M. Arias, and W. B. Jakoby, eds.), Series, No. 6, Raven Press, New York, pp. 115–135.Google Scholar
  199. 197.
    Brown, J. R., Beebe, G. W., Kurtzke, J. F., Loewenson, R. B., Silberberg, D. H., and Tourtellotte, W. W., 1979, Neurology (Minneap.) 29:3–23.CrossRefGoogle Scholar
  200. 198.
    Bauer, H. J., 1978, Neurology (Minneap.) 28:8–19.CrossRefGoogle Scholar
  201. 199.
    Rothfelder, U., Neu, I., and Pelka, R., 1982, Munch. Med. Wochenschr. 124:46–54.Google Scholar
  202. 200.
    Ammitzboll, T., Clausen, J., and Fog, T., 1975, Acta Neurol. Scand. [Suppl.] 63 , 99–111.Google Scholar
  203. 201.
    Theys, P., Gosseye-Lissoir, F., Ketelaer, P., and Carton, H., 1981, J. Neurol. 225:119–133.PubMedCrossRefGoogle Scholar
  204. 202.
    Dau, P. C., Petajan, J. H., Johnson, K. P., Panitch, H. S., and Bornstein, M. B., 1980, Neurology (N.Y.) 30:1023–1028.CrossRefGoogle Scholar
  205. 203.
    Neu, I., 1982, Munch. Med. Wochenschr. 124:77.Google Scholar
  206. 204.
    Fog, T., Pedersen, L., Raun, N. E., Kam-Hansen, S., Mellerup, E., Platz, P., Ryder, L. P., Jakobsen, B. K., and Grob, P., 1978, Lancet 1:851–853.PubMedCrossRefGoogle Scholar
  207. 205.
    Basten, A., Pollard, J. D., Steward, G. J., Frith, J. A., McLeod, J. G., Walsh, J. C., Garrick, R., and v. der Brink, C. M., 1980, Lancet 2:931–934.PubMedCrossRefGoogle Scholar
  208. 206.
    Boehme, D. H., Fordice, M. W., and Marks, N., 1974, Brain Res. 75:153–162.PubMedCrossRefGoogle Scholar
  209. 207.
    Boehme, D. H., Umezawa, H., Hashim, G., and Marks, N., 1978, Neurochem. Res. 3:185–194.PubMedCrossRefGoogle Scholar
  210. 208.
    Sibley, W. A., Kiernat, J., and Laguna, J. F., 1978, Neurology (Minneap.) 28:102–105.CrossRefGoogle Scholar
  211. 209.
    Amaducci, L., Inzitari, D., Sita, D., Antuono, P., Capparelli, R., and Arfaioli, C., 1979, Acta Neurol. 34:214–258.Google Scholar
  212. 210.
    Millar, J. H. D., Zilkha, K. J., Langman, M. J. S., Payling-Wright, H., Smith, A. D., Belin, J., and Thompson, R. H. S., 1973, Br. Med. J. 1973:765–768.CrossRefGoogle Scholar
  213. 211.
    Bates, D., Fawcett, P. R. W., Shaw, D. A., and Weightman, D., 1978, Br. Med. J. 1978:1390–1391.CrossRefGoogle Scholar
  214. 212.
    Paty, D. W., Cousin, H. K., Read, S., and Adlakha, K., 1978, Acta Neurol. Scand. 58:53–58.PubMedCrossRefGoogle Scholar
  215. 213.
    Dworkin, R. H., 1981, Lancet 1:1153–1154.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Jørgen Clausen
    • 1
    • 2
  1. 1.The Neurochemical InstituteCopenhagenDenmark
  2. 2.Institute for Biology and ChemistryRoskilde UniversityRoskildeDenmark

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