Nalorphine: Conditioning of Drug Effects on Operant Performance

  • Steven Robert Goldberg


When the morphine treatment of a physically dependent organism is abruptly discontinued, intense physiologic and behavioral signs and symptoms appear within a few hours of the last drug dose, reach a peak in intensity in 24 to 48 hours, and then gradually subside (Eddy, Halbach, Isbell, and Seevers, 1965; Jaffe, 1965). This complex of signs and symptoms, called the morphine-abstinence syndrome, includes anxiety, restlessness, disruption of ongoing behavior, increases in behavior motivated by drug acquisition, perspiration, salivation, mydriasis, body temperature changes, muscular aching and twitching, elevation of heart rate and respiratory rate, anorexia, and vomiting (Jaffe, 1965).


Conditioned Stimulus Unavoidable Electric Shock Conditioned Suppression Control Session Acquisition Session 
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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Steven Robert Goldberg
    • 1
  1. 1.Department of PharmacologyHarvard Medical SchoolBostonUSA

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