Drug Conditioning and Drug Effects on Cardiovascular Conditional Functions

  • Jorge Perez-Cruet

Abstract

The modern application of some old and general laws of conditional behavior to physiologic and pharmacologic problems is a novel phenomenon in American science. The general laws of conditional behavior were first explored and postulated by Pavlov (1928) and Thorndike (1911) some fifty years ago. Pavlov established that the fundamental process of conditioning was psychic in nature and that it depended on two major variables: a conditional stimulus and a reinforcement. More recently, with the discovery of the stimulus properties of drugs, the area of conditioning and behavioral science acquired additional dimensions in terms of both experimental and clinical applications. The present report concerns the use of drugs and classical Pavlovian conditioning procedures in the study of cardiovascular function.

Keywords

Conditional Stimulus Conditional Reflex Cardiovascular Function Aortic Blood Flow Hypothalamic Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Anderson, O.D., Parmenter, R., and Liddell, H.S. Some cardiovascular manifestations of the experimental neurosis in sheep. Psych osom. Med., 1939, 1, 93.Google Scholar
  2. Beier, D.C. Conditioned cardiovascular responses and suggestions for the treatment of cardiac neuroses. J. Exp. Psychol., 1940, 26, 311.CrossRefGoogle Scholar
  3. Black, A.H., Carlson, N.J., and Solomon, R.L. Exploratory studies of the conditioning of autonomic responses in curarized dogs. Psychol. Monogr., 1962, 76, (29, Whole No. 548).CrossRefGoogle Scholar
  4. Bridger, W.H. and Gantt, W.H. The effect of mescaline on differentiated conditional reflexes. Amer. J. Psychiat., 1956, 113, 352.PubMedGoogle Scholar
  5. Burch, G.E. Digital rheoplethysmographic study of the orienting reflex in man. Psycho-som. Med., 1961, 23, 403.Google Scholar
  6. Bykov, K.M. The Cerebral Cortex and the Internal Organs. Trans, by W.H. Gantt. New York, Chemical Publishing Co., Inc., 1957.Google Scholar
  7. Bykov, K.M. Textbook of Physiology. Trans, by S. Belsky and D. Myshne. Moscow, Foreign Languages Publishing House, 1958.Google Scholar
  8. Cohen, D.H. and Durkovic, R.G. Cardiac and respiratory conditioning, differentiation and extinction in the pigeon. J. Exp. Anal. Behav., 1966, 9, 681.PubMedCrossRefGoogle Scholar
  9. De Jong, H.H. Experimental Catatonia. Baltimore, The William & Wilkins Co., 1945.Google Scholar
  10. De Jong, H.H. A historical and personal approach to the development of experimental psychiatry. J. Clin. Psychiat. Exp. Psychopath., 17:388, 1956.Google Scholar
  11. Dykman, R.A. and Gantt, W.H. Relation of experimental tachycardia to amplitude of motor activity and intensity of the motivating stimulus. Amer. J. Physiol., 1956, 185, 495.PubMedGoogle Scholar
  12. Evans, R.I. A dialogue with B.F. Skinner. Psychiatry and Social Science Review, 1969, 3 11.Google Scholar
  13. Feldberg, W. and Sherwood, S.L. Injections of bulbocapnine into the cerebral ventricles of cats. Brit. J. Pharmacol, 1955, 10, 371.PubMedGoogle Scholar
  14. Fleck, S. and Gantt, W.H. Fractional conditioning of behavior based on electrically induced convulsions. Fed. Proc, 1949, 8, 47. (Abstract)Google Scholar
  15. Gantt, W.H. Experimental studies in animals of the effects of drugs on cardiac stress symptoms.J. Neuropsychiat, 1964, 5, 472.PubMedGoogle Scholar
  16. Gantt, W.H., Katzenelbogen, S., and Loucks, R.B. An attempt to condition adrenaline hyperglycemia. Bull. Hopkins Hosp., 1937, 60, 400.Google Scholar
  17. Gliedman, L.H. and Gantt, W.H. The effects of reserpine and chlorpromazine on orien-tiang behavior and retention of conditioned reflexes. Southern Med.J., 1956, 49, 880.PubMedCrossRefGoogle Scholar
  18. Hernández-Peón, R., Chávez-Ibarra, G., Morgane, P.J., and Timolaria, C. Limbic cholinergic pathways involved in sleep and emotional behavior. Exp. Neurol., 1963, 8, 93.CrossRefGoogle Scholar
  19. Katzenelbogen, S., Loucks, R.B., and Gantt, W.H. Conditional reflex secretion. Amer. J. Physiol., 1939, 128, 10.Google Scholar
  20. Malmo, R.B. Classical and instrumental conditioning with septal stimulation as reinforcement. J. Comp. Physiol. Psychol, 1965, 60, 1.PubMedCrossRefGoogle Scholar
  21. MacKenzie, T.M. and Gantt, W.H. Cardiac acceleration to atropine cannot be conditioned. Fed. Proc, 1950, 9, 83. (Abstract)Google Scholar
  22. Newton, J.E.O. and Perez-Cruet, J. Successive-beat analysis of cardiovascular orienting and conditional responses. Conditional Reflex, 1967, 2, 37.Google Scholar
  23. Obrist, P. and Webb, R.A. Heart rate during conditioning in dogs: Relationship to somatic-motor activity. Psychophysiology, 1967, 4, 7.PubMedCrossRefGoogle Scholar
  24. Passouant, P., Passouant-Fontaine, T.H., and Cadilhac, J. Modifications de l’excitabilité du cortex et de diverses structures sous-corticales au cours de la catalepsie provoquée par la bulbocapnine chez le Chat. C. R. Soc. Biol. (Paris), 1955, 149, 2185.Google Scholar
  25. Pavlov, L.P. The Work of the Digestive Glands. Trans, by W.H. Thompson. London, Griffin & Co., 1910.Google Scholar
  26. Pavlov, L.P. Lectures on conditioned reflexes. Trans, by W.H. Gantt. New York, International Publishers Co., Inc. 1928.Google Scholar
  27. Perez-Cruet, J. Conditional-reflex electrocardiogram in dogs. Thesis presented to the Award Committee, University of Puerto Rico School of Medicine, 1956.Google Scholar
  28. Perez-Cruet, J. Conditioning of extrasystoles in humans with respiratory maneuvers as unconditional stimulus. Science, 1962, 137, 1060.PubMedCrossRefGoogle Scholar
  29. Perez-Cruet, J. The effects of bulbocapnine on classical cardiorespiratory conditional reflexes. Paper presented at the Society for Psychophysiological Research, Detroit, 1963(a).Google Scholar
  30. Perez-Cruet, J. Electrocardiographic conditioning with hypothalamic stimulation as an unconditional stimulus. Clinical Research, 1963(b), 77, 395. (Abstract)Google Scholar
  31. Perez-Cruet, J. Cardiorespiratory components of conditional catalepsy to bulbocapnine. In H. Brill ed. Proceedings of the Fifth International Congress of Neuropsychopharmacology. Amsterdam, Excerpta Medica Foundation, S. 129, 1966(a), 912.Google Scholar
  32. Perez-Cruet, J. The effect of person on heart rate in monkeys. Clinical Research, 1966(b), 14, 257.Google Scholar
  33. Perez-Cruet, J. Chronic painless recording of intra-arterial blood pressure in unanesthetized dogs. Conditioned Reflex, 1967, 2, 80.Google Scholar
  34. Perez-Cruet, J. Heart-rate conditioning with hypothalamic stimulation as an unconditional stimulus. Proceedings of the International Union of Physiological Sciences, 1968, 7, 344.Google Scholar
  35. Perez-Cruet, J. and Gaertner, R.A. Cardiodynamics of cardiac conditioning. Clinical Research, 1966, 14, 257. (Abstract)Google Scholar
  36. Perez-Cruet, J. and Gaertner, R.A. Cardiac conditioning in dogs with chronic bilateral cervicalvagotomies. Fed. Proc, 1967, 26, 328. (Abstract)Google Scholar
  37. Perez-Cruet, J. and Gaertner, R.A. Hemodynamic changes accompanying various patterns of classical cardiac conditional reflexes in dogs. Clinical Research, 1968, 16, 243. (Abstract)Google Scholar
  38. Perez-Cruet, J. and Gantt, H.W. Conditional reflex electrocardiogram of bulbocapnine: Conditioning of the T-wave. Amer. Heart J., 1964, 67, 61.PubMedCrossRefGoogle Scholar
  39. Perez-Cruet, J. and Newton, J.E.O. Effect of b -adrenergic blockage by propranolol on cardiovascular conditioning. Clinical Research, 1967, 15, 218. (Abstract)Google Scholar
  40. Perez-Cruet, J., Jude, J.R., and Gantt, W.H. An attempt to condition extrasystoles using direct myocardial electrical stimulation as an unconditional stimulus. Conditional Reflex, 1966, 1, 104.Google Scholar
  41. Perez-Cruet, J., Tolliver, G., Dunn, G., Marvin, S., and Brady, J.V. Concurrent measurement of heart rate and instrumental avoidance behavior in the rhesus monkey. J. Exp. Anal. Behav., 1963, 6, 61.PubMedCrossRefGoogle Scholar
  42. Poloni, A. and Maffezzoni, G. Le variazioni dell’ attivitá colinergica del tussuto cerebrale per effetto delia bulbocapnina, delia mescalina e delia dietilamide dell’ acido lisergico. Sist. Nerv. (Milano), 1952, 4, 578.PubMedGoogle Scholar
  43. Robinson, J. and Gantt, W.H. The orienting reflex (questioning reaction): Cardiac, respiratory, salivary, and motor components. Johns Hopkins Hospital Bulletin, 1947, 80, 231.Google Scholar
  44. Schneiderman, N., Smith, M.C., Smith, A.C., and Gormezano, I. Heart rate classical conditioning in rabbits. Psychonomic Science, 1966, 6, 241.Google Scholar
  45. Smith, K. Conditioning as an artifact. Psycholo. Rev., 1954, 61, 217.CrossRefGoogle Scholar
  46. Smith, O.A. and Stebbins, W.C. Conditioned blood flow and heart rate in monkeys. J. Comp. Physiol. Psychol., 1965, 59, 432.PubMedCrossRefGoogle Scholar
  47. Stern, J.A. and Word, T.J. Heart rate changes during avoidance conditioning in the male albino rat. J. Psychosom. Res., 1962, 6, 167.PubMedCrossRefGoogle Scholar
  48. Teitelbaum, H.A., Gantt, W.H., and Stone, S. Cardiac conditional reflexes can be formed to pain but not to acetylcholine. J. Nerv. Ment. Dis., 1956, 123, 484.PubMedCrossRefGoogle Scholar
  49. Thorndike, E.L. Animal Intelligence: Experimental studies. New York, The Macmillan Company, 1911.CrossRefGoogle Scholar
  50. Wilder, A. and Pescor, F.T. Classical conditioning of a morphine-abstinence phenomenon, reinforcement of opioid-drinking behavior and “relapse” in morphine-addicted rats. In H. Brill ed. Proceedings of the Fifth International Congress of Neuropsychopharmacology, Amsterdam, Excerpta Medica Foundation, S. 129, 1966, 831.Google Scholar
  51. Zeaman, D., Deane, G., and Wegner, N. Amplitude and latency characteristics of the conditioned heart response. J. Psychol., 1954, 38, 235.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Jorge Perez-Cruet
    • 1
  1. 1.Laboratory of Clinical PharmacologyThe National Heart InstituteBethesdaUSA

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