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Replication of Alphaviruses in Mosquito Cells

  • Chapter
The Togaviridae and Flaviviridae

Part of the book series: The Viruses ((VIRS))

Abstract

The alphaviruses are members of a group of infectious agents once referred to as “arboviruses” (arthropod-borne viruses). Although alphaviruses are clearly identified as agents of human and animal disease, the term arbovirus recognizes the active roles of invertebrates in the natural life cycle of these viruses. Alphaviruses are perpetuated in the wild, in part, through an interplay between insect and vertebrate hosts and are transmitted to vertebrates by the bite of infected arthropods, usually mosquitos or ticks. The use of the term “insect vector” to describe the invertebrate counterpart implies a reduced importance, or possibly passive role, of the insect in the transmission of these agents to vertebrates. It is very clear today that active replication of alphaviruses in the invertebrate is essential to the perpetuation of the virus in nature. Furthermore, it now appears that the constant participation of the vertebrate host may not be essential for the maintenance of these viruses in the wild. Evidence strongly suggests that alphaviruses (as well as other insect-borne viruses) are transmitted vertically (transovarially) from generation to generation (for a review, see Leake, 1984).

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  1. Cell Research Institute and Department of Microbiology, The University of Texas at Austin, Austin, Texas, 78713, USA

    Dennis T. Brown & Lynn D. Condreay

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  1. Department of Microbiology and Immunology, Washington University School of Medicine, 63110, St. Louis, Missouri, USA

    Sondra Schlesinger  & Milton J. Schlesinger  & 

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Brown, D.T., Condreay, L.D. (1986). Replication of Alphaviruses in Mosquito Cells. In: Schlesinger, S., Schlesinger, M.J. (eds) The Togaviridae and Flaviviridae. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0785-4_7

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