Multidrug Abuse

  • Marc A. Schuckit
Part of the Critical Issues in Psychiatry book series (CIPS)


The format of this chapter differs slightly from that of the rest of the text; it emphasizes some major types of drug interactions. Because the focus is on the relationships among types of drugs of abuse, careful reading of this chapter will give you an opportunity to review much of the material already presented. In other words, chapter 13 reviews the general lessons given in this text about drug interactions.


Multiple Drug Withdrawal Syndrome Antisocial Personality Disorder Toxic Reaction Opiate Dependence 
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  1. 1.
    Kaufman, E. The abuse of multi drugs. 1. Definition, classification, and extent of problem. American Journal of Drug and Alcohol Abuse 3: 272–292, 1976.Google Scholar
  2. 2.
    Cohen, S. Polydrug abuse. Drug Abuse and Alcoholism Newsletter 5:1–5, 976 San Diego: Vista Hill Foundation.Google Scholar
  3. 3.
    National Clearinghouse for Drug Abuse Information. Polydrug Use: An Annotated Bibliography. Rockville, Maryland: National Institute on Drug Abuse, 1975.Google Scholar
  4. 4.
    Goodwin, D. W., und Guze, S. B. (Eds.). Psychiatric Diagnosis ( 4th ed. ). New York: Oxford University Press, 1988.Google Scholar
  5. 5.
    Schuckit, M. A. Alcoholism and sociopath’—Diagnostic confusion. Quarterly Journal of Studies on Alcohol 34:157–164, 1973.Google Scholar
  6. 6.
    Schuckit, M. A. Alcohol and drug interactions with antianxiety medications. American Journal of Medicine 82: 27–32, 1987.PubMedCrossRefGoogle Scholar
  7. 7.
    Hawkins, M. R., Kruzich, D. J., und Smith, J. D. Prevalence of polydrug use among alcoholic soldiers. American Journal of Drug and Alcohol Abuse 11: 27–35, 1985.PubMedCrossRefGoogle Scholar
  8. 8.
    Ogbome, A. C., und Kapur, B. M. Drug use among a sample of males admitted to an alcohol detoxification center. Alcoholism: Clinical and Experimental Research 11: 183–185, 1987.CrossRefGoogle Scholar
  9. 9.
    Vaillant, G. Natural history of male alcoholism. V. Is alcoholism the cart or the horse? Paper presented at the American Psychiatric Association Annual Meeting, Toronto, Ontario, May 1982.Google Scholar
  10. 10.
    Kraus, J. Juvenile drug abuse and delinquency: Some differential associations. British Journal of Psychiatry 139: 422–430, 1981.PubMedCrossRefGoogle Scholar
  11. 11.
    Hamburg, B. A., Kraemer, H. C., und Jahnke, W. A hierarchy of drug use in adolescence: Behavioral and attitudinal. American Journal of Psychiatry 132: 1155–1164, 1975.PubMedGoogle Scholar
  12. 12.
    Kandel, D. Antecedents of adolescent initiation into stages of drug use. In D. Kandel (Ed.), Longitudinal Research on Drug Use. Washington, D.C.: Hemisphere Publishing, 1978, pp. 73100.Google Scholar
  13. 13.
    Gould, L. C., und Kleber, H. D. Changing patterns of multiple drug use among applicants to a multimodality drug treatment program. Archives of General Psychiatry 31: 408–413, 1974.PubMedCrossRefGoogle Scholar
  14. 14.
    Lane, E. A., Guthrie, S., und Linnoila, M. Effects of ethanol on drug and metabolite pharmacokinetics. Clinical Pharmacokinetics 10: 228–247, 1985.PubMedCrossRefGoogle Scholar
  15. 15.
    Guthrie, S. K., und Lane, E. A. Reinterpretation of the pharmacokinetic mechanism of oral benzodiazepine ethanol interaction. Alcoholism: Clinical and Experimental Research 10: 686–690, 1986.CrossRefGoogle Scholar
  16. 16.
    Chan, A. W., Langan, M. C., Leong, F. W., Substitution of chlordiazepoxide for ethanol in alcohol-dependent mice. Alcohol 3: 309–316, 1986.PubMedCrossRefGoogle Scholar
  17. 17.
    Suzdak, P. D., Glowa, J. R., und Crawley, J. N. Is ethanol antagonist Ro15–4513 selective for ethanol? Science 239: 648–650, 1988.CrossRefGoogle Scholar
  18. 18.
    Freund, G., und Ballniger, W. E.: Decrease of benzodiazepine receptors in frontal cortex of alcoholics with normal brains at autopsy. Alcoholism: Clinical and Experimental Research 10:110, 1986.Google Scholar
  19. 19.
    Suzdak, P. D., Glowa, J. R., und Crawley, J. N. A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 234:1243–1248, 1986.Google Scholar
  20. 20.
    Britton, K. T., und Koob, G. F. Ethanol antagonist Rol 5–4513 is not selective for ethanol. Alcoholism: Clinical and Experimental Research 11: 225, 1987.Google Scholar
  21. 21.
    Nutt, D. J., und Lister, R. Studies of the putative alcohol antagonist Ro15–4513. Alcoholism: Clinical and Experimental Research 11: 218, 1987.Google Scholar
  22. 22.
    Cohen, S. Psychotropic drug interactions. Drug Abuse and Alcoholism Newsletter 6(6). San Diego: Vista Hill Foundation, 1977.Google Scholar
  23. 23.
    Siegel, S. Alcohol and opiate dependence: Re-evaluation of the Victorian perspective. In S. Siegel (Ed.), Research Advances in Alcohol and Drug Problems, Vol. 9, 1986, pp. 279–314.CrossRefGoogle Scholar
  24. 24.
    Fidecka, S., Tamborska, E., Malec, D. und Langwinski, R. The development of cross tolerance between ethanol and morphine. Polish Journal of Pharmacology and Pharmacy 38: 277–284, 1986.PubMedCrossRefGoogle Scholar
  25. 25.
    Nyers, R. D., Borg, S., und Mossberg, R. Antagonism by naltrexone of voluntary alcohol selection in the chronically drinking macaque monkey. Alcohol 3: 383–388, 1986.CrossRefGoogle Scholar
  26. 26.
    Cheong Ton, J. M., und Amit, Z. Stereospecifrc interaction between alcohol and opiates mediated by the Mu high-affinity binding receptor. Alcohol 2: 333–337, 1985.CrossRefGoogle Scholar
  27. 27.
    Trachtenberg, M. C., und Blum, K. Alcohol and opioid peptides: Neuropharmacological rationale for physical craving of alcohol. American Journal of Drug and Alcohol Abuse 13: 365–372, 1987.PubMedCrossRefGoogle Scholar
  28. 28.
    Kosten, T. R., Rounsaville, B. J., und Kleber, H. D. Parental alcoholism in opioid addicts. Journal of Nervous and Mental Disease 173: 461–468, 1985.PubMedCrossRefGoogle Scholar
  29. 29.
    Joseph, H., und Appel, P. Alcohol and methadone treatment: Consequences for the patient and program. American Journal of Drug and Alcohol Abuse 11:37–53, 1985.Google Scholar
  30. 30.
    Kosten, T. R., Gawin, F. H., Rounsaville, B. J., und Kleber, H. D. Cocaine abuse among opioid addicts: Demographic and diagnostic factors in treatment. American Journal of Drug and Alcohol Abuse 12: 1–16, 1986.PubMedCrossRefGoogle Scholar
  31. 31.
    Siemens, A. J., Kalant, H., und Khanna, J. M. Effects of cannabis on pentobarbital induced sleeping time and pentobarbital metabolism in the rat. Biochemical Pharmacology 23: 477–489, 1974.PubMedCrossRefGoogle Scholar
  32. 32.
    Janowsky, D. S., Meacham, M. P., Blanc, J. D.,. Simulated flying performance after marihuana intoxication. Aviation, Space, and Environmental Medicine 47: 124–128, 1976.Google Scholar
  33. 33.
    Whitehead, P. C., und Ferrence, R. G. Alcohol and other drugs related to young drivers’ traffic accident involvement. Journal of Safety Research 8: 65–72, 1976.Google Scholar
  34. 34.
    Schuckit, M. A., und Irwin, M. The clinical characteristics of 171 primary alcoholics. Paper presented at the American College of Neuropsychopharmacology Annual Meeting, San Juan, Puerto Rico, December 5, 1987.Google Scholar
  35. Simpson, D. D., und Sells, S. B. Patterns of multiple drug abuse: 1969–1971. International Journal of the Addictions 9: 301–314, 1974.Google Scholar
  36. 36.
    Blackford, L. Student drug use surveys-San Mateo County, California, 1968–1975. San Mateo, California: Department of Public Health and Welfare, June 6, 1975.Google Scholar
  37. 37.
    Cook, R. F., Hostetter, R. S., und Ramsay, D. A. Patterns of illicit drug use in the Army. American Journal of Psychiatry 132: 1013–1017, 1975.PubMedGoogle Scholar
  38. 38.
    Fischer, D. E., Halikas, J. A., Baker, J. W., et al. Frequency and pattems of drug abuse in psychiatric patients. Diseases of the Nervous System 36: 550–553, 1975.PubMedGoogle Scholar
  39. 39.
    Green, J., und Jaffe, J. H. Alcohol and opiate dependence: A review. Journal of Studies on Alcohol 38: 1274–1293, 1977.PubMedGoogle Scholar
  40. 40.
    Schuckit, M. A., und Morrissey, E. R. Propoxyphene and phencyclidine (PCP) use in adolescents. Journal of Clinical Psychiatry 39: 7–13, 1978.PubMedGoogle Scholar
  41. 41.
    Callan, J. P., und Patterson, C. P. Pattems of drug abuse among military inductees. American Journal of Psychiatry 130: 260–264, 1973.PubMedGoogle Scholar
  42. 42.
    Prichep, L. S., Cohen, M., Kaplan, J., Psychiatric evaluation services to court referred drug users. American Journal of Drug and Alcohol Abuse 2: 197–213, 1975.PubMedCrossRefGoogle Scholar
  43. 43.
    Sapira, J. D., und Cherubin, C. E. Drug Abuse: A Guide for the Clinician. Excerpta Medica, Amsterdam. New York: American Elsevier, 1975.Google Scholar
  44. 44.
    Smith, D. E., und Wesson, D. R. Phenobarbital technique for treatment of barbiturate dependence. Archives of General Psychiatry 24: 56–60, 1971.PubMedCrossRefGoogle Scholar
  45. 45.
    Reuler, J. B., Girard, D. E., und Nardone, D. A. The chronic pain syndrome: Misconceptions and management. Annals of Internal Medicine 93: 588–596, 1980.PubMedCrossRefGoogle Scholar
  46. 46.
    Sternbach, R. A. Pain: Psychophysiologic Analysis. New York: Academic Press, 1968.Google Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Marc A. Schuckit
    • 1
  1. 1.San Diego School of Medicine, Veterans Administration HospitalUniversity of CaliforniaSan DiegoUSA

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