Glues, Solvents, and Aerosols

  • Marc A. Schuckit
Part of the Critical Issues in Psychiatry book series (CIPS)


This short chapter deals with a heterogeneous group of industrial substances that share the ability to produce generalized central nervous system (CNS) depression and signs of confusion through disturbances in physiological functioning within neurons. 1–4 Although the intermittent use of solvents was noted in the last century,4 more widespread misuse began with the inhalation of model airplane glue in the early 1960s.4,5 Despite the efforts of the hobby industry to modify its products by removing some of the more toxic substances and adding an irritating smell, the abuses have continued, and intoxication through inhalation has spread to aerosol propellants and industrial solvents.4


Organic Brain Syndrome Nervous System Damage Chronic Inhalation Tetraethyl Lead Inhalant Abuse 
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  1. 1.
    Garriott, J., and Petty, C. S. Death from inhalant abuse: Toxicological and pathological evaluation of 34 cases. Clinical Toxicology 16: 305–315, 1980.PubMedCrossRefGoogle Scholar
  2. 2.
    Glaser, F. B. Inhalation psychosis and related states. In P. G. Bourne (Ed.), A Treatment Manual for Acute Drug Abuse Emergencies. Washington, D.C.: U.S. Government Printing Office, 1974, pp. 95–104.Google Scholar
  3. 3.
    Struve, G., Knave, B., and Mindus, P. Neuropsychiatric symptoms in workers occupationally exposed to jet fuels: A combined epidemiological and causal study. Acta Psychiatrica Scandinavica 303: 57–67, 1983.Google Scholar
  4. 4.
    Hoffman, F. G. A Handbook on Drug and Alcohol Abuse. New York: Oxford University Press, 1975.Google Scholar
  5. 5.
    Glatt, M. M. Abuse of solvents “for kicks.” Lancet 1: 485, 1977.PubMedCrossRefGoogle Scholar
  6. 6.
    Steadman, C., Dorrington, L. C., Kay, P., and Stephens, H. Abuse of a fire-extinghishing agent and sudden death in adolescents. Medical Journal of Australia 141:115–117, 1984.Google Scholar
  7. 7.
    Faillace, L. A., and Guynn, R. W. Abuse of organic solvents. Psychosomatics 17: 88–189, 1976.Google Scholar
  8. 8.
    Jaffe, J. H. Drug addiction and drug abuse. In A. G. Gilman, L. S. Goodman, T W. Rah, and F. Murad (Eds.), The Pharmacological Basis of Therapeutics ( 7th ed. ). New York: Macmillan, 1985, pp. 532–567.Google Scholar
  9. 9.
    King, G. S., Smialek, J. E., and Troutman, W. G. Sudden death in adolescents resulting from the inhalation of typewriter correction fluid. Journal of the American Medical Association 253:16041606, 1985.Google Scholar
  10. 10.
    Daniels, A. M., and Latchman, R. W. Petrol sniffing and schizophrenia in a Pacific island paradise. Lancet 1: 389, 1984.PubMedCrossRefGoogle Scholar
  11. 11.
    O’Flynn, R. R., Murphy, E., and Waldron, H. A. Violence and solvents. Lancet 2: 1470, 1987.PubMedCrossRefGoogle Scholar
  12. 12.
    Cohen, S. Inhalant abuse. Drug Abuse and Alcoholism Newsletter 6(9). San Diego: Vista Hill Foundation, 1975.Google Scholar
  13. 13.
    Yamawaki, S., Segawa, T., and Sarai, K. Effects of acute and chronic toluene inhalation on behavior and 3H-serotonin binding in the rat. Life Sciences 30: 1977–2002, 1982.CrossRefGoogle Scholar
  14. 14.
    Fuxe, K., Andersson, K., Nilsen, O. D., Solvent abuse. Toxicology Letters 12:115, 1982.Google Scholar
  15. 15.
    Clark, D., and Tinton, D. Acute inhalation toxicity of some halogenated and non-halogenated hydrocarbons. Human Toxicology 1: 239–247, 1982.PubMedCrossRefGoogle Scholar
  16. 16.
    Editorial: Solvents and the central nervous system. Lancet 2: 565–566, 1981.Google Scholar
  17. 17.
    Adriani, J. Drug dependence in hospitalized patients. In P. G. Boume (Ed.), A Treatment Manual for Acute Drug Abuse Emergencies. Washington, D.C.: U.S. Government Printing Office, 1974, pp. 125–136.Google Scholar
  18. 18.
    Editorial: Solvent abuse. Lancet 2:1139–1140, 1982.Google Scholar
  19. 19.
    Lewis, P. W., and Patterson, D. Acute and chronic effects of the voluntary inhalation of certain commercial volatile solvents by juveniles. Journal of Drug Issues 3:162–175, 1974.Google Scholar
  20. 20.
    Daniels, A. M., and Fazakerley, R. C. Solvent abuse in the Central Pacific. Lancet 1:75, 1983.Google Scholar
  21. 21.
    Lewis, J. D., Moritz, D., and Mellis, L. P. Long-term toluene abuse. American Journal of Psychiatry 138: 368–370, 1981.PubMedGoogle Scholar
  22. 22.
    Crites, J., and Schuckit, M. A. Solvent misuse in adolescents at a community alcohol center. Journal of Clinical Psychiatry 40: 63–67, 1979.Google Scholar
  23. 23.
    Hershey, C. O. and Miller, S. Solvent abuse: A shift to adults. International Journal of Addictions 17: 1085–1089, 1982.Google Scholar
  24. 24.
    Albeson, H., Cohen, R., Schrayer, D., Drug experience, attitudes, and related behavior among adolescents and adults. In The National Commission on Marijuana and Drug Abuse (Ed.), The Technical Papers of the Second Report of the National Commission on Marijuana and Drug Abuse, Vol. 1. Washington, D.C.: U.S. Government Printing Office, 1972.Google Scholar
  25. 25.
    Editorial: National survey finds continuing decline in use of illicit drugs by high school seniors. Hospital and Community Psychiatry 36: 1011–1012, 1985.Google Scholar
  26. 26.
    Mason, T. Inhalant Use and Treatment. NIDA Services Research Monograph Series, U.S. Department of Health, Education and Welfare Publication No. ADM 79–793, Washington, D.C.: U.S. Govemment Printing Office, 1979.Google Scholar
  27. 27.
    Beavais, F., Oetting, E. R., and Edwards, R. W. Trends in the use of inhalants among American Indian adolescents. White Cloud Journal 3: 3–11, 1985.Google Scholar
  28. 28.
    Reed, B. J. F., and May, P. A. Inhalant abuse and juvenile delinquency: A controlled study in Albuquerque, New Mexico. International Journal of the Addictions 9: 789–803, 1984.Google Scholar
  29. 29.
    Jacobs, A. M., and Ghodse, A. H. Delinquency and regular solvent abuse. British Journal of Addiction 83: 965–968, 1988.PubMedCrossRefGoogle Scholar
  30. 30.
    DeBarona, M. S., and Simpson, D. D. Inhalant users in drug abuse prevention programs. American Journal of Drug and Alcohol Abuse 10: 503–518, 1984.CrossRefGoogle Scholar
  31. 31.
    Westermeyer, J. The psychiatrist and solvent-inhalant abuse: Recognition, assessment, and treatment. American Journal of Psychiatry 44: 903–907, 1987.Google Scholar
  32. 32.
    Dager, S. R., Holland, J. P., Cowley, D. S., and Dunner, D. L. Panic disorder precipitated by exposure to organic solvents in the work place. American Journal of Psychiatry 144: 1056–1058, 1987.PubMedGoogle Scholar
  33. 33.
    May, D. C., and Boltzer, M. J. A report of occupational deaths attributed to flurocarbon-113. Archives of Environmental Health 39: 352–355, 1984.PubMedCrossRefGoogle Scholar
  34. 34.
    Ross, W. D., and Sholiton, M. C. Specificity of psychiatric manifestations in relation to neurotoxic chemicals. Acta Psychiatrica Scandinavica 303:100–104, 1983.Google Scholar
  35. 35.
    Goldbloom, D., and Chouinard, G. Schizophreniform psychosis associated with chronic industrial toluene exposure: Case report. Journal of Clinical Psychiatry 46: 350–351, 1985.PubMedGoogle Scholar
  36. 36.
    Dinwiddie, S. H., Zorumski, C. F., and Rubin, E. H. Psychiatric correlates of chronic solvent abuse. Journal of Clinical Psychiatry 48: 334–337, 1987.PubMedGoogle Scholar
  37. 37.
    Elofsson, S. A., Gamberale, F., Hindmarsch, T., et al. Physical problems associated with solvent abuse. Scandinavian Journal of Work and Environmental Health 6: 239, 1980.CrossRefGoogle Scholar
  38. 38.
    Fornazzari, L., Wilkinson, D. A., and Kapur, B. M. Cerebellar, cortical and functional impairment in toluene abusers. Acta Neurologica Scandinavica 67: 319–329, 1983.PubMedCrossRefGoogle Scholar
  39. 39.
    Lazar, R. B., Mo, S. O., and Meien, O. Multifocal central nervous system damage caused by toluene abuse. Neurology 33: 1337–1340, 1983.PubMedCrossRefGoogle Scholar
  40. 40.
    Allison, W. M., and Jerone, D. W. A. Glue sniffing: A pilot study of the cognitive effects of longterm use. International Journal of the Addictions 19: 453–458, 1984.PubMedGoogle Scholar
  41. 41.
    Morse, J. M. D., and Thomas, E. Hepatic toxicity from disinfectant abuse. Journal of the American Medical Association 252: 1904, 1984.PubMedCrossRefGoogle Scholar
  42. 42.
    Stybel, L. J. Deliberate hydrocarbon inhalation among low socioeconomic adolescents not necessarily apprehended by the police. International Journal of the Addictions 11: 345–361, 1976.PubMedGoogle Scholar
  43. 43.
    Ravnskoy, U. Hydrocarbon exposure and glomerulonephritis. Lancet 2: 1214, 1983.CrossRefGoogle Scholar
  44. 44.
    Fagan, D. G., and Forrest, J. B. “Sudden sniffing death” after inhalation of domestic lipid—aerosol. Lancet 2: 361, 1977.PubMedCrossRefGoogle Scholar
  45. 45.
    Schikler, K. N., Lane, E. E., Seitz, K., and Collins, W. M. Solvent abuse associated with pulmonary abnormalities. Advances in Alcohol and Substance Abuse 3: 75–81, 1984.PubMedCrossRefGoogle Scholar
  46. 46.
    Tenenbein, M., deGroot, W., and Rajani, K. R. Peripheral neuropathy following intentional inhalation of naphtha fumes. Canadian Medical Association Journal 131:1077–1079, 1984.Google Scholar
  47. 47.
    Holmberg, P. C. Central-nervous-system defects in children born to mothers exposed to organic solvents during pregnancy. Lancet 2: 177–179, 1979.PubMedCrossRefGoogle Scholar
  48. 48.
    Goodwin, J. M., Geil, C., Grodner, B., et al. Inhalant abuse, pregnancy, and neglected children. American Journal of Psychiatry 138: 1126, 1981.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Marc A. Schuckit
    • 1
  1. 1.San Diego School of Medicine, Veterans Administration HospitalUniversity of CaliforniaSan DiegoUSA

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