H-2 Antigens pp 769-778 | Cite as

The Role of H-2 Gene Complex in Experimental Autoimmune Thyroiditis

  • Yi-chi M. Kong
  • Chella S. David
Part of the NATO ASI Series book series (NSSA, volume 144)


Susceptibility to experimental autoimmune thyroiditis (EAT) was linked to the H-2 complex in 1971 by the use of inbred strains of independent haplotypes on different backgrounds1,2. For example, mice of the k or s haplotype are susceptible (good responder); they develop severe thyroiditis, in addition to autoantibodies to MTg, after immunization with mouse thyroglobulin (MTg) in complete Freund’s adjuvant (CFA). In contrast, mice of the b or d haplotype are resistant (poor responder), with little, if any, cellular infiltration in the thyroid, despite the presence of MTg autoantibodies. In the past 10 years, the influence of various H-2 genes on EAT induction and development has been examined in detail. These studies may be grouped into three sections.


Recombinant Strain Susceptible Mouse Autoantibody Titer Cell Proliferative Response Recombinant Congenic Strain 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Yi-chi M. Kong
    • 1
    • 2
  • Chella S. David
    • 1
    • 2
  1. 1.Department of Immunology and Microbiology Wayne StateUniversity School of MedicineDetroitUSA
  2. 2.Department of ImmunologyMayo Medical SchoolRochesterUSA

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