Advertisement

H-2 Antigens pp 757-767 | Cite as

Expression of H-2 Genes and Susceptibility to Parasitic Infection

  • Donald L. Wassom
  • Christopher J. Krco
  • Chella S. David
Part of the NATO ASI Series book series (NSSA, volume 144)

Abstract

The term parasitism is difficult to define. Many infectious organisms such as bacteria or fungi, live at the expense of their hosts, yet are not usually regarded as parasites. In contrast, certain protozoans or helminths which live in close association with their hosts, but cause no demonstrable disease, are called parasites nonetheless. For present purposes, the discussion of immunity to parasites will be restricted to immune responses induced in vertebrate hosts following exposure to protozoan, helminth, or arthropod “parasites”. While such a distinction is arbitrary, it follows conventional practice. Following a brief discussion of immunity to parasitic infections in very general terms, results from studies of Trichinella spiralis-infected mice will be reviewed to provide specific examples of how H-2 genes may influence the outcome of such host-parasite interactions.

Keywords

Parasitic Infection Adult Worm Female Worm Express Cell Surface Recombinant Tumor Necrosis Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Flood, P.M., Benoist, C., Mathis, D., and Murphy, D.B.: Altered I-J phenotype in Ea transgenic mice. Proc Natl Acad Sci, 83: 8308–8312, 1986.PubMedCrossRefGoogle Scholar
  2. Hayes, C.E., Klyczek, K.K., Krum, D.D., Whitcomb, R.M., Hullett, D.A., and Cantor, H.: Chromosome 4 Jt gene controls murine T cell surface I-J expression. Science, 223: 559–563.Google Scholar
  3. Moeller, G. ed.: I-J. Immunol Rev vol 83, 1985.Google Scholar
  4. Müller, V., Jongeneel, C.V., Nedospasov, S.A., Fischer-Lindahl, K., and Steinmetz, M.: Tumor necrosis factor and lymphotoxin genes map close to H-2D in the mouse major histocompatibility complex. Nature, 325: 265–267, 1987.PubMedCrossRefGoogle Scholar
  5. Ruddle, N.H.: Tumor necrosis factor and related cytotoxins. Immunol Today, 8: 129–130, 1987.CrossRefGoogle Scholar
  6. Shapiro, L.H., Dugan, E.S., and Neiderhuber, J.E.: Monoclonal antibody characterization of a unique immune response control locus between H-2 S and D. J Exp Med, 162: 1477–1493, 1985.PubMedCrossRefGoogle Scholar
  7. Silberstein, D.S., and David, J.R.: Tumor necrosis factor enhances eosinophil toxicity to Schistosoma mansoni Larvae. Proc Natl Acad Sci, 83: 1055–1059, 1986.PubMedCrossRefGoogle Scholar
  8. Sumida, T., Sado, T., Kojima, M., Ono, K., Kamisaku, H., and Taniguchi, M.: I-J as an idiotype of the recognition component of antigen-specific suppressor T-cell factor. Nature, 316: 738–741, 1985.PubMedCrossRefGoogle Scholar
  9. Taverne, J., Tavernier, J., Fiers, W., and Playfair, J.H.L.: Recombinant tumor necrosis factor inhibits malaria parasites in vivo but not in vitro. Clin Exp Immunol, 67: 1–4, 1987.PubMedCentralPubMedGoogle Scholar
  10. Uracz, W., Asano, Y., Abe, R., and Tada, T.: I-J epitopes are adaptively acquired by T cells differentiated in the chimaeric condition. Nature, 316: 741–743, 1985.PubMedCrossRefGoogle Scholar
  11. Waltenbaugh, C., Sun, L., and Lei, H.-Y.: Regulation of immune responses by I-J gene products. VI. Recognition of I-E molecules by I-J-bearing suppressor factors. J. Exp. Med., 163: 797–811, 1986.PubMedCrossRefGoogle Scholar
  12. Wassom, O.L., David, C.S., and Gleich, G.J.: Genes within the major histocompatibility complex influence susceptibility to Trichinella spiralis in the mouse. Immunogenetics, 9: 491–496, 1979.CrossRefGoogle Scholar
  13. Wassom, D.L., David, C.S., and Gleich, G.J.: MHC-linked genetic control of the immune response to parasites: Trichinella spiralis in the mouse. In Skamene E, Kongshavn, P.A.L., and Landy, M. (eds.) “Genetic Control of Natural Resistance to Infection and Malignancy.” New York Academic Press pp 75–82, 1980.CrossRefGoogle Scholar
  14. Wassom, D.L., Brooks, 8.0., Babish, J.G., and David, C.S.: A gene mapping between the S and D regions of the H-2 complex influences resistance to Trichinella spiralis infections of mice. J Immunogenetics, 10: 371–378, 1983.Google Scholar
  15. Wassom, D.L., Krco, C.J., and David, C.S.: I-E expression and susceptibility to parasite infection. Imnunol Today, 8: 39–43, 1987.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Donald L. Wassom
    • 1
  • Christopher J. Krco
    • 2
  • Chella S. David
    • 2
  1. 1.School of Veterinary MedicineUniversity of Wisconsin-MadisonMadisonUSA
  2. 2.The Department of ImmunologyMayo Clinic & Mayo Medical SchoolRochesterUSA

Personalised recommendations