H-2 Antigens pp 757-767 | Cite as

Expression of H-2 Genes and Susceptibility to Parasitic Infection

  • Donald L. Wassom
  • Christopher J. Krco
  • Chella S. David
Part of the NATO ASI Series book series (NSSA, volume 144)


The term parasitism is difficult to define. Many infectious organisms such as bacteria or fungi, live at the expense of their hosts, yet are not usually regarded as parasites. In contrast, certain protozoans or helminths which live in close association with their hosts, but cause no demonstrable disease, are called parasites nonetheless. For present purposes, the discussion of immunity to parasites will be restricted to immune responses induced in vertebrate hosts following exposure to protozoan, helminth, or arthropod “parasites”. While such a distinction is arbitrary, it follows conventional practice. Following a brief discussion of immunity to parasitic infections in very general terms, results from studies of Trichinella spiralis-infected mice will be reviewed to provide specific examples of how H-2 genes may influence the outcome of such host-parasite interactions.


Parasitic Infection Adult Worm Female Worm Express Cell Surface Recombinant Tumor Necrosis Factor 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Donald L. Wassom
    • 1
  • Christopher J. Krco
    • 2
  • Chella S. David
    • 2
  1. 1.School of Veterinary MedicineUniversity of Wisconsin-MadisonMadisonUSA
  2. 2.The Department of ImmunologyMayo Clinic & Mayo Medical SchoolRochesterUSA

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