H-2 Antigens pp 719-724 | Cite as

H-2-linked Control of the Susceptibility of Mice to Cleft Palate Induced by Cortisone and Testosterone

  • David L. Gasser
  • Chhanda Gupta
  • Allen S. Goldman
Part of the NATO ASI Series book series (NSSA, volume 144)


In the course of mapping H–2–linked genes which control susceptibility to cortisoneinduced cleft palate, we have observed that certain pairs of congenic strains which have been considered to have the same H–2–recombinant chromosomes differ in their susceptibility. The B10.A(1R) and B10.A(2R) congenic strains have been believed to possess the same a/b crossover in the S/D interval, but B10.A(2R) is significantly more susceptible than B10.A(1R). Likewise, the B10.A(18R) and B10.BAR5 strains have been considered to have the same b/a crossover in the S/D interval, but B10.BAR5 is significantly more susceptible than B10.A(18R). In order to assess the possible effects of these genes on susceptibility to other steroids, we have injected pregnant mice on days 11 through 14 with testosterone. We have observed significant differences among H-2 congenic strains in the frequency of testosterone-induced fetal resorption. Among surviving fetuses, there were significant differences in the frequency of testosterone-induced cleft palate.


Glucocorticoid Receptor Cleft Palate Mouse Mammary Tumor Virus Pregnant Mouse Congenic Strain 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • David L. Gasser
    • 1
  • Chhanda Gupta
    • 1
  • Allen S. Goldman
    • 2
  1. 1.Department of Human GeneticsUniversity of Pennsylvania School of Medicine, and Children’s Hospital of PhiladelphiaPhiladelphiaUSA
  2. 2.Center for Craniofacial Anomalies and Department of PediatricsThe University of Illinois College of Medicine at ChicagoUSA

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