In Vivo Antitumor Effects of Anti-I-A Antibodies
In addition to their expression on various normal cells of the immune system, la molecules are present on a variety of neoplastic cells, most importantly for the work described here on the surface of virtually all B-cell lymphomas and leukemias1. As an extension of our previous studies2–4 on the in vivo effects of I-A-specific monoclonal antibodies (Mab), we have investigated their effects on an I-A-bearing B cell lymphoma. Differential effects on normal and neoplastic cells were observed, suggesting that Ia molecules on neoplastic cells are excellent targets for antibody attack in vivo.
KeywordsSpleen Cell Antibody Dependent Cellular Cytotoxicity L10A Cell Antigen Present Cell Activity Spleen Colony
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