Abstract
Induction of mammary tumors by hormonal stimulation from heterotopic hypophyseal isografts has been studied in H-2 congenic mouse strains free of infectious mammary tumor virus. Significant differences in tumor incidence have been observed, indicating that H-2-linked genes influence the tumorigenesis in hormonally stimulated mammary glands. In addition, significant differences between the H-2 congenic strains were found in estrogen receptor levels measured in the hypophyseal isografts. These differences do not appear to correlate in any obvious way with the induction of mammary tumors. Our data indicate that the MHC or MHC-linked genes influence one or more steps related to hormonal regulation of the mammary gland.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ashley, R.L., Cardiff, R.D., and Fanning, T.G.: Reevaluation of the effect of mouse mammary tumor virus infection on the BALB/c mouse hyperplastic outgrowth. J. Natl. Cancer Inst. 65 977-986, 1980
Bailey, D.W., and Hoste, J.: A gene governing the female immune response to the male antigen in mice. Transplantation 11 404 - 407, 1971
Ballard, P.L.: Hormones and receptors in developing lung. Progr. Clin. Biol. Res. 140 103-117, 1983
Boot, L.M., Kwa, H.G., and Röpcke, G.: Hormonal induction of the mouse mammary tumors. In J. Hilgers and M. Sluyser (eds.): Mammary tumors in the mouse pp. 117 - 200, Elsevier/North-Holland Biomedical Press, Amsterdam, 1981
Carlsson, K.S., Smith, B.T., and Post, M.: Insulin acts on the fibroblast to inhibit glucocorticoid stimulation of lung maturation. J. Appl. Physiol. 57 1577-1579, 1984
Demant, P.: Corticosteroid-induced cleft palate: Cis interaction of MHC genes and hybrid resistance. Immunogenetics 22 183-188, 1985
Dunn, T.B.: Morphology of mammary tumors in mice. In F. Homburger (ed.): Physiopathology of Cancer 2nd ed., pp. 38-814, Hoeber, New York, 1959
Dux, A.: Multiple genetic factors in the MHC and predominant role of D-end in the resistance against C3H-MTV-induced mammary tumors. Transpl. Proc. 15 2101-2103, 1983
Dux, A., and Demant, P.: The influence of the MHC on resistance against C3H-MTV induced mammary tumors is predominantly systemic rather than local. Int. J. Cancer in press
Hitchcock, K.R.: Lung development and the pulmonary surfactant system: hormonal influences. Anat. Rec. 198 13-3-4, 1980
Klein, J., Figueroa, R., and David, C.S.: H-2 haplotypes, genes and antigens: Second listing. II. The H-2 complex. Immunogenetics 17 553-596, 1983
Kwa, H.G., Verstraeten, A.A., and Scheijde-Bakker, M.G.M.: Isolation of prolactin from the granular fraction of pituitary tumour transplants: Improved method for the isolation of mouse and rat prolactin for radioimmunoassay. Eur. J. Cancer 8 33-38, 1972
Long, C.A., Vaidya, A.B., and Dumaswala, U.J.: Influence of the major histocompatibility complex on susceptibility to MuMTV. Abstract 12th meeting on mammary cancer in experimental animals and man, Maastricht, 1980
Mantel, N.: Evaluation of survival data and two new rank order statistics arising and its consideration. Cancer Chemother. Rep. 50 163-170, 1966
Mühlbock, 0., and Dux, A.: Histocompatibility genes and susceptibility to mammary tumor virus (MTV) in mice. Transpl. Proc. 3 1247-1250, 1971
Mühlbock, 0., and Dux, A.: Histocompatibility genes and mammary cancer. In J. Hilgers and M. Sluyser (eds.): Mammary tumors in the mouse pp. 5145-572, Elsevier/North-Holland Biomedical Press, Amsterdam, 1981
Nagasawa, H., Yanai, R., Taniguchi, H., Tokuzen, R., and Nakahara, W.: Two way selection of a stock of Swiss albino mice for mammary tumorigenesis: Establishment of two new strains (SHN and SLN). J. Natl. Cancer Inst. 57 1425-429, 1976
Oomen, L.C.J.M., Demant, P., Hart, A.A.M., and Emmelot, P.: Multiple genes in the H-2 complex affect differently the number and growth rate of transplacentally induced lung tumors in mice. Int. J. Cancer 31: 447-454, 1983
Palumbo, D.A., and Vladutiu, A.O.: Estrogen receptor in uteri of mice of different H-2 genotypes. Experientia 35 1103-11014, 1979
Röpcke, G.: Interaction of hypophyseal isografts and ovarian hormones in mammary tumour development in mice. Thesis University of Amsterdam, 1975
Sluyser, M., Boot, L.M., and Röpcke, G.: High estrogen and low progestin receptor levels in outgrowths of hypophyseal isografts. Cancer Res. 38: 2859 - 2860, 1978
Smith, B.T., and Sabry, K.: Glucocorticoid-thyroid synergism in lung maturation: A mechanism involving epithelial-mesenchyneal interaction. Proc. Natl. Acad. Sci. USA 80 1951-1954, 1983
Zijlstra, M., Vasmel, W.L.E., Radaskiewicz, T., Matthews, E., and Melief, C.J.M.: The H-2 complex regulates both the susceptibility to murine viral lymphomagenesis and the phenotype of the virus-induced lymphomas. J. of Immunogenetics 13 69-76, 1986
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer Science+Business Media New York
About this chapter
Cite this chapter
Röpcke, G., Sluyser, M., Demant, P. (1987). The H-2 Complex and the Hormonal Factors in Mammary Tumorigenesis in Mice. In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_65
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0764-9_65
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0766-3
Online ISBN: 978-1-4757-0764-9
eBook Packages: Springer Book Archive