H-2 Antigens pp 681-689 | Cite as

The H-2 Complex and the Hormonal Factors in Mammary Tumorigenesis in Mice

  • G. Röpcke
  • M. Sluyser
  • P. Demant
Part of the NATO ASI Series book series (NSSA, volume 144)


Induction of mammary tumors by hormonal stimulation from heterotopic hypophyseal isografts has been studied in H-2 congenic mouse strains free of infectious mammary tumor virus. Significant differences in tumor incidence have been observed, indicating that H-2-linked genes influence the tumorigenesis in hormonally stimulated mammary glands. In addition, significant differences between the H-2 congenic strains were found in estrogen receptor levels measured in the hypophyseal isografts. These differences do not appear to correlate in any obvious way with the induction of mammary tumors. Our data indicate that the MHC or MHC-linked genes influence one or more steps related to hormonal regulation of the mammary gland.


Mammary Gland Hormonal Stimulation Mouse Mammary Tumor Virus Congenic Strain Mammary Tumorigenesis 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • G. Röpcke
    • 1
  • M. Sluyser
    • 1
  • P. Demant
    • 1
  1. 1.Departments of Molecular Genetics and Tumor Biology The Netherlands Cancer InstitutePlesmanlaan 121AmsterdamThe Netherlands

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