Abstract
Our group first documented that viral infections and virus-induced transformations can significantly affect class I gene expression. These virally-induced alterations in H-2 (class I) antigen expression were shown to play a striking role in resistance to neoplasia18. Similar observations which have recently been made by numerous investigators in a variety of other systems 6, 8, 12, 24, 26.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Banerji, J., Olsson, L., and Shaffner, W., A lymphocyte specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chains, Cell, 33, 729, 1983.
Blatt, C., Milham, K., Haas, M., Nesbitt, M. N., Harper, M. E., and Simon, M. I., Chromosomal mapping of the mink cell focus-inducing and xenotropic env gene family in the mouse, Proc. Natl. Acad. Sci. USA, 80, 6298, 1983.
Borelli, E., Hen, R., and Chambon, P., Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription, Nature (London), 312, 608, 1984.
Burgert, H. G. and Kvist, S., An adenovirus type 2 glycoprotein blocks cell 41. Dierks, P., Ooyen, A. V. A. N., Cochran, M. D., Dobkin, C., Reiser, J., and Weissman, C., Three regions upstream from the cat site are required for effective and accurate transcription of the rabbit globin gene in mouse 3T6 cells, Cell, 32, 695, 1983.
Dierks, P., Ooyen, A. V. A. N., Cochran, M. D., Dobkin, C., Reiser, J., and Weissman, C., Three regions upstream from the cat site are required for effective and accurate transcription of the rabbit globin gene in mouse 3T6 cells, Cell, 32, 695, 1983.
Eager, K. B., Williams, J., Breiding, D., Pan, S., Knowles, B., Apella, E., and Ricciardi, R. P., Expression of histocompatibility antigens H-2K, D, and K is reduced in adenovirus-12-transformed mouse oells and is restored by interferon gamma, Proc. Natl. Acad. Sci. USA, 82, 5525, 1985.
Gluzman, Y. and Shenk, T., Eds., Enhancers and eukaryotic gene expression, Cold Spring Harbor Laboratory, Cold Spring Harbor, 1983.
Hui, K., Grosveld, F., and Festenstein, H., Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation, Nature (London), 311, 750, 1984.
Kimura, A., Israel, A., LeBail, O., and Kourilsky, P., Detailed analysis of the mouse H-2K“ promoter: enhancer-like sequences and the role in the regulation of class I gene expression, Cell, 44, 261, 1986.
McKnight, S. L. and Kingsbury, R., Transcriptional control signals of a eukaryotic protein-coding gene, Science, 217, 316, 1982.
Meruelo, D.: Retroviral sequences flanking histocompatibility genes alter their expression, function and evolution. A Hypothesis. In “Genetic Control of Host Resistance to Infection and Immunity,” Skamene, E. (ed) Alan R. Liss, Inc. New York, pp 655–669, 1985.
Mellow, G. H., Fohring, B., Doughert, J., Gallimore, P. H., and Raska, K., Tumorigenicity of adenovirus-transformed rat cells and expression of Class I histocompatibility antigen, Virology, 134, 460, 1984.
Meruelo, D., A role for elevated H-2 antigen expression in resistance to RadLV-induced leukemogenesis: Enhancement of effective tumor surveillance by killer lymphocytes, J. Exp. Med., 149, 898, 1979.
Meruelo, D., Kornreich, R., Rossomando, A., Pampeno, C., Boral, A., Silver, J. L., Buxbaum, J., and Weiss, E. H., Devlin, J. J., Mellor, A. L., Flavell, R. A. and Pellicer, A., Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA, Proc. Natl. Acad. Sci. USA, 83, 4504, 1986.
Meruelo, D., Kornreich, R., Rossomando, A., Pampeno, C., Mellor, A. L., Weiss, E. H., Flavell, R. A., and Pellicer, A., Murine leukemia virus sequences are encoded in the murine major histocompatibility complex, Proc.Natl. Acad. Sci. USA, 81, 1804, 1984.
Meruelo, D. and Kramer, J., H2-D control of radiation leukemia virus induced neoplasia: Evidence for interaction of viral and H-2 genomic information, Transplant. Proc., 13, 1858, 1981.
Meruelo, D., Lieberman, M., Ginzten, M., Deak, B., and McDevitt, H. O., Genetic control of Radiation Leukemia virus-induced tumorigenesis. I. Role of the murine major histocompatibility complex H-2, J. Exp. Med., 146, 1079, 1977.
Meruelo, D., Nimelstein, S. H., Jones, P. P., Lieberman, M., and McDevitt, H. O., Increased synthesis and expression of H-2 antigens on lymphocytes as a result of radiation leukemia virus infection: A possible mechanism for H-2 linked control of virus-induced neoplasia, J. Exp. Med., 147, 470, 1978.
Meruelo, D., Rossomando, A., Offer, M., Buxbaum, J., and Pellicer, A., Association of endogenous viral loci with genes encoding murine histocompatibility and lymphocyte differentiation antigens, Proc. Natl. Acad. Sci. USA, 80, 5032, 1983.
Olsson, L., Identification of a gene and its product associated with metastatic activity, Fed. Proc. Fed. Am. Soc. Exp. Biol., 44, 1336, 1985.
Olsson, L. and Forchhamer, J., Induction of the metastatic phenotype in a mouse tumor by 5-azacytine and characterization of an antigen associated with metastatic activity, Proc. Natl. Acad. Sci. USA, 81, 3389, 1984.
Pampeno, C. L. and Meruelo, D., Isolation of a retroviruslike sequence from the TL locus of the C57BL/10 murine major histocompatibility complex, J. Virol., 58, 296, 1986.
Rossomando, A. and Meruelo, D., Viral sequences are associated with many histocompatibility genes, Immunogenetics, 23, 233, 1986.
Schrier, P. I., Bernards, R., Vaessen, R. T. M. J., Houweling, A., and van der Eb, A. J., Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cell, Nature (London), 305, 771, 1983.
Tanaka, K., Isselbacher, K. J., Khoury, G., and Jay, G., Reversal of oncogenesis by the expression of a MHC class I gene, Science, 228, 26, 1985.
Wallick, R., Bulbuc, N., Hammerling, G. J., Katzav, S., Segal, S., and Feldman, M., Abrogation of metastatic properties of tumor cells by de novo expression of H-2K antigens following H-2 gene transfection, Nature (London), 315, 301, 1985.
Wejman, J. C., Taylor, B. A., Jenkins, N. A., and Copeland, N. G., Endogenous xenotropic murine leukemia virus-related sequences map to chromosomal regions encoding mouse lymphocyte antigens, J. Virol., 50, 237, 1984.
Wettstein, P. J. and Melvold, R. W., Xenotropic virus related restriction patterns of non-H2 histocompatibility mutant mice strains, Immunogenetics, 23, 156, 1986.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer Science+Business Media New York
About this chapter
Cite this chapter
Meruelo, D. (1987). Regulation of H-2 Class I Gene Expression in Virus Transformed and/or Infected Cells. In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_62
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0764-9_62
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0766-3
Online ISBN: 978-1-4757-0764-9
eBook Packages: Springer Book Archive