Abstract
The studies described here address the hypothesis that class II molecules (Ia) serve not only as restriction elements for cognate T cell:B cell interaction, but also as signal transducers involved in B cell activation. We have tested this hypothesis by studying modulation of B cell physiology by anti-Ia antibodies. Specifically, we have assessed the ability of these antibodies to induce “second” messenger generation and to modulate cell proliferative and differentiative responses to LPS and anti IgM antibodies.
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Newell, M.K. et al. (1987). Do Class II Major Histocompatibility Molecules Function as Signal Transducers during B Lymphocyte Activation?. In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_53
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DOI: https://doi.org/10.1007/978-1-4757-0764-9_53
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