H-2 Antigens pp 501-515 | Cite as

A Role for Ia Antigens in B Cell Activation: Studies with Normal B Cells and A B Cell Lymphoma

  • Arthur R. Baluyut
  • V. Udhyakumar
  • J. Morris
  • Bondada Subbarao
Part of the NATO ASI Series book series (NSSA, volume 144)

Abstract

Monoclonal anti-Ia antibodies enhanced anti-μ induced proliferation of murine B lymphocytes. Anti-Ia induced augmentation of B cell proliferation was allele specific and did not require participation by T cells and adherent cells. The effects of anti-Ia antibodies on B cell activation are neither due to induction of interleukin-1 secretion in the cultures nor due to interaction with the Fc receptors and can be demonstrated under serum-free culture conditions. Monoclonal antibodies against both IA and IE region encoded Ia molecules were able to synergize with anti-μ in inducing B cell proliferation. Antibodies to both IA and IE coded antigens induced IgM secretion from the B lymphoma cell lines BKS3 and BKL. The anti-Ia antibodies did not affect the proliferation of the B lymphoma cells. These results suggest that the interaction of B cell surface Ia with the anti-Ia antibodies results in an activation signal and that the B cell surface Ia antigens may function as signal transducer molecules.

Keywords

Cell Lymphoma Spleen Cell Proliferative Response Limulus Amebocyte Lysate Assay Monoelonal Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Arthur R. Baluyut
    • 1
  • V. Udhyakumar
    • 1
  • J. Morris
    • 1
  • Bondada Subbarao
    • 1
  1. 1.Department of Microbiology and Immunology Sanders-Brown Center on AgingUniversity of KentuckyLexingtonUSA

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