The Major Histocompatibility Complex of the BALB/C Mouse: Gene Organization and Recombination

  • Michael Steinmetz
  • Yasushi Uematsu
Part of the NATO ASI Series book series (NSSA, volume 144)


We have recently witnessed how efficiently a genetic region even as large as the major histocompatibility complex (MHC) of the mouse can be studied for structure and function using the powerful tools of molecular biology. The rapid progress was dependent, however, on the vast amount of genetic, serologic, biochemical and functional information that had been accumulated for the MHC genes over the past fifty years since their discovery by Peter Gorer (1936). In particular due to the availability of large numbers of inbred, congenic and recombinant congenic mouse strains (Snell, 1981) molecular genetic studies have advanced more rapidly for the mouse MHC as compared to man (for reviews see: Hood et al., 1983; Steinmetz and Hood, 1983; Möller, 1985a, b and c; Flavell et al., 1986; Klein, 1986).


Major Histocompatibility Complex Major Histocompatibility Complex Antigen Mouse Major Histocompatibility Complex Region Gene Cluster Laboratory Mouse Strain 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Michael Steinmetz
    • 1
  • Yasushi Uematsu
    • 2
  1. 1.Central Research UnitsF. Hoffmann-La Roche & Co.Ltd.BaselSwitzerland
  2. 2.Basel Institute for ImmunologyBaselSwitzerland

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