H-2 Antigens pp 479-484 | Cite as

The Major Histocompatibility Complex and the T Cell Repertoire

  • Guy Gammon
  • Nilabh Shastri
  • Stanley Wilbur
  • Shahrzad Sadegh-Nasseri
  • John Cogswell
  • Alexander Miller
  • Eli Sercarz
Part of the NATO ASI Series book series (NSSA, volume 144)

Abstract

We examined the ability of peptides corresponding to different regions of hen eggwhite lysozyme to stimulate proliferative T-cell responses in several mouse strains. The relationship of the major histocompatibility complex (MHC) and other non-MHC genes to the T cell repertoire was studied. It was found that the MHC was the major influence on the specificity of the T cell repertoire. The T cell response following immunization with native hen eggwhite lysozyme was also investigated. Challenge with the whole protein preferentially induces responses to some determinants compared to others. Hence, some regions of the protein appear to be immunodominant while other determinants are sub-dominant.

Keywords

Major Histocompatibility Complex Proliferative Response Major Histocompatibility Complex Gene Cell Repertoire Cyanogen Bromide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Guy Gammon
    • 1
  • Nilabh Shastri
    • 1
  • Stanley Wilbur
    • 1
  • Shahrzad Sadegh-Nasseri
    • 1
  • John Cogswell
    • 1
  • Alexander Miller
    • 1
  • Eli Sercarz
    • 1
  1. 1.UCLA Department of MicrobiologyLos AngelesUSA

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