H-2 Antigens pp 359-369 | Cite as

A Q Region Product as a CTL Restriction Element?

  • Donal B. Murphy
  • Robert J. Homer
Part of the NATO ASI Series book series (NSSA, volume 144)


The function of class I genes mapping in the Q and TL regions of the MHC is unknown. Data presented in this study will show that two genes control a determinant (Qc-1) recognized by cloned cytotoxic T lymphocytes (CTL). One gene is a class I gene and maps in the Q region. The second gene maps in the K-end of the MHC and has tentatively been mapped between A ß3 and A ß2 with recombinant strains. Monoclonal antibody reactive with Q region encoded class I molecules blocks CTL recognition of the Qc-1 determinant at the target cell level. An attractive interpretation of these data is that the Q region class I molecule serves as a CTL restriction element for the recognition of a K-end encoded peptide.


Spleen Cell Recombinant Strain Region Class Restriction Element Cytolytic Assay 
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© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Donal B. Murphy
    • 1
  • Robert J. Homer
    • 1
  1. 1.Section of Immunobiology and Department of PathologyYale University School of MedicineNew HavenUSA

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