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Historical Developments in Understanding the Function of Class I MHC Genes

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Book cover H-2 Antigens

Part of the book series: NATO ASI Series ((NSSA,volume 144))

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Abstract

It is reasonable to state that, as late as 1973, the reason for the existence and extraordinary polymorphism of the strong transplantation antigens (now known as the class I MHC glycoproteins) was not understood (Amos et al., 1971; Bodmer, 1972). Two sets of facts were undisputed: that the allograft response was extremely potent, and that the frequency of effector T cells specific for foreign transplantation antigens was very high (Simonsen, 1967; Wilson, et al., 1968). This had led to a variety of speculations, a few of the more perceptive of which are listed in Table 1.

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  1. Department of Experimental Pathology, The John Curtin School Medical Research, Canberra, ACT, 2601, Australia

    Peter C. Doherty

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  1. Mayo Clinic, Rochester, Minnesota, USA

    Chella S. David Ph.D.

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Doherty, P.C. (1987). Historical Developments in Understanding the Function of Class I MHC Genes. In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_34

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