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The End of H-2

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H-2 Antigens

Part of the book series: NATO ASI Series ((NSSA,volume 144))

Abstract

Mta, the maternally transmitted antigen of mice, was discovered and its analysis was pursued because it seemingly had nothing to do with H-2. Immunization of NZB/B1NJ mice with H-2-compatible BALB/c cells gave rise to cytotoxic T lymphocytes (CTL) that killed target cells of more than eighty strains of mice, independent of their H-2 type. Cold target competition showed that they all shared one antigen, and it was hard to find a strain whose cells were not lysed (Fischer Lindahl et al. 1980). Mta was thus a clear exception to the rule that CTL are H-2-restricted, i.e. recognize their target antigens in association with one of the class I major histocompatibility antigens (MHC I), H-2K, H-2D and H-2L. Obviously, we were not dealing with a rare case of MHC II-restricted CTL either.

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References

  • Barton, S.C., Surani, M.A.H., and Norris, M.L., 1984. Roles of paternal and maternal genomes in mouse development. Nature, 311: 374.

    Article  PubMed  CAS  Google Scholar 

  • Chan, T., and Fischer Lindahl, K., 1985. Skin graft rejection due to a maternally transmitted antigen, Mta. Transplantation, 39: 477.

    Article  CAS  Google Scholar 

  • Fazekas de St.Groth, S., 1981. The joint evolution of antigens and antibodies, in: “The Immune System. Vol. I: Past and Future,” C.M. Steinberg and I. Lefkovits, eds., Karger, Basel, pp. 155.

    Google Scholar 

  • Ferris, S.D., Ritte, U., Fischer Lindahl, K., Prager, E.M., and Wilson, A.C., 1983. Unusual type of mitochondrial DNA in mice lacking a maternally transmitted antigen. Nucleic Acids Res., 11: 2917.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Fischer Lindahl, K., 1984. The Mta of spretus mice and new alleles of Hmt and Mtf. Ann. Rep. Basel Inst. Immunol., 13: 90.

    Google Scholar 

  • Fischer Lindahl, K., 1985a. Mitochondrial inheritance in mice. Trends Genet., 1: 135.

    Article  CAS  Google Scholar 

  • Fischer Lindahl, K., 1985b. The Hmt alleles of t haplotypes. Ann. Rep. Basel Inst. Immunol., 14: 64.

    Google Scholar 

  • Fischer Lindahl, K., 1985c. Tissue typing using biosynthetically labeled monoclonal antibodies, in: “Immunological Methods, Vol. III,” I. Lefkovits and B. Pernis, eds., Academic Press, New York, pp. 187.

    Google Scholar 

  • Fischer Lindahl, K., 1986. Genetic variants of histocompatibility antigens from wild mice. Curr. Top. Microbiol. Immunol., 127: 272.

    PubMed  CAS  Google Scholar 

  • Fischer Lindahl, K., and Bürki, K., 1982. Mta, a maternally inherited cell surface antigen of the mouse, is transmitted in the egg. Proc. Natl. Acad. Sci. U.S.A., 79: 5362.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Fischer Lindahl, K., and Hausmann, B., 1983. Cytoplasmic inheritance of a cell surface antigen in the mouse. Genetics, 103: 483.

    PubMed  CAS  Google Scholar 

  • Fischer Lindahl, K., and Langhorne, J., 1981. Medial histocompatibility antigens. Scand. J. Immunol., 14: 643.

    Article  PubMed  CAS  Google Scholar 

  • Fischer Lindahl, K., Bocchieri, M., and Riblet, R., 1980. Maternally transmitted target antigen for unrestricted killing by NZB T lymphocytes. J. Exp. Med., 152: 1583.

    Article  Google Scholar 

  • Fischer Lindahl, K., Hausmann, B., and Chapman, V.M., 1983. A new H-2-linked class I gene whose expression depends on a maternally transmitted factor. Nature, 306: 383.

    Article  PubMed  CAS  Google Scholar 

  • Fischer Lindahl, K., Hausmann, B., Robinson, P.J., Guénet, J.-L., Wharton, D.C., and Winking, H., 1986. Mta, the maternally transmitted antigen, is determined jointly by the chromosomal Hmt and the extrachromosomal Mtf genes. J. Exp. Med., 163: 334.

    Article  PubMed  CAS  Google Scholar 

  • Fischer Lindahl, K., Hausmann, B., and Guénet, J.-L., 1987. Distinct epitopes of the maternally transmitted antigen, Mta, determined by three allelic forms of the cytoplasmic gene Mtf. Submitted for publication.

    Google Scholar 

  • Fujimoto, S., and Yamagishi, H., 1987. Isolation of an excision product of T-cell receptor a-chain gene rearrangements. Nature, 327: 242.

    Article  PubMed  CAS  Google Scholar 

  • Gotch, F., Rothbard, J., Howland, K., Towsend, A., and McMichael, A., 1987. Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2. Nature, 326: 881.

    Article  PubMed  CAS  Google Scholar 

  • Han, A.C., Rodgers, J.R., and Rich, R.R., 1987. Unglycosylated Mtaa expressed an Mtab-like determinant. Immunogenetics, 25: 234.

    Article  PubMed  CAS  Google Scholar 

  • Hirama, M., and Fischer Lindahl, K., 1985. Mouse mitochondria and the cell surface, in: “Achievements and perspectives of mitochondrial research, Vol. II: Biogenesis,” E. Quagliariello, E.C. Slater, F. Palmieri, C. Saccone, and A.M. Kroon, eds., Elsevier, Amsterdam, pp. 445.

    Google Scholar 

  • Huston, M.M., Smith, R., III, Huston, D.P., and Rich, R.R., 1983. Differences in maternal lineages of New Zealand black mice defined by restriction endonuclease analysis of mitochondrial DNA and by expression of maternally transmitted antigen. J. Exp. Med., 157: 2154.

    Article  PubMed  CAS  Google Scholar 

  • Huston, M.M., Smith, R., III, Hull, R., Huston, D.P., and Rich, R.R., 1985. Mitochondrial modulation of maternally transmitted antigen: analysis of cell hybrids. Proc. Natl. Acad. Sci. U.S.A., 82: 3286.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Hyafil, F. and Strominger, J.L., 1979. Dissociation and exchange of the 52-microglobulin subunit of HLA-A and HLA-B antigens. Proc. Natl. Acad. Sci. U.S.A., 76: 5834.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Jeng, M.W., Finegold, M.J., Basch, R.S., and Lamm, M.E., 1978. Demonstration of thymus-leukemia (TL) antigens on mitochondria of lymphoid cells by immunoelectron microscopy. Lab. Invest., 38: 41.

    PubMed  CAS  Google Scholar 

  • Kiefer, M.C., Steinmetz, M., and Fischer Lindahl, K., 1985. Genetic mapping in the Tla:Qa-1 region of the mouse MHC by restriction enzyme site polymorphisms. Ann. Rep. Basel Inst. Immunol., 14: 51.

    Google Scholar 

  • McGrath, J., and Solter, D., 1984. Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell, 37: 179.

    Article  PubMed  CAS  Google Scholar 

  • Morrison, L.A., Lukacher, A.E., Braciale, V.L., Fan, D.P., and Braciale, T.J., 1986. Differences in antigen presentation to MHC class I- and II-restricted influenza virus-specific cytolytic T lymphocyte clones. J. Exp. Med., 163: 903.

    Article  PubMed  CAS  Google Scholar 

  • Murphy, D.B., and Homer, R.H., 1987. A Q region product as a restriction element, in: “Major Histocompatibility Genes and their Roles in Immune Function,” C.S. David, ed., Plenum, New York.

    Google Scholar 

  • Okazaki, K., Davis, D.D., and Sakano, H., 1987. T cell receptor ß gene sequences in the circular DNA of thymocyte nuclei: direct evidence for intramolecular DNA deletion in V-D-J joining. Cell, 49: 477.

    Article  PubMed  CAS  Google Scholar 

  • Palmiter, R.D., Wilkie, T.M., Chen, H.Y., Brinster, R.L., 1983. Transmission distortion and mosaicism in an unusual transgenic mouse pedigree. Cell, 36: 869.

    Article  Google Scholar 

  • Parnes, J.R., and Seidman, J.G., 1982. Structure of wild type and mutant mouse 52-microglobulin genes. Cell, 29: 661.

    Article  PubMed  CAS  Google Scholar 

  • Rodgers, J.R., Smith, R., III, Huston, M.M., and Rich, R.R., 1986. Maternally transmitted antigen. Adv. Immunol., 33: 313.

    Article  Google Scholar 

  • Rodgers, J.R., Smith, R., III, and Rich, R.R., 1987. Maternally transmitted antigens are codominantly expressed by mouse cells containing two kinds of mitochondrial DNA. J. Exp. Med., 165: 560.

    Article  PubMed  CAS  Google Scholar 

  • Shen, F.W., Chaganti, R.S.K., Doucette, L.A., Litman, G.W., Steinmetz, M., Hood, L., and Boyse, E.A., 1984. Genomic constitution of an H-2:Tla variant leukemia. Proc. Natl. Acad. Sci. U.S.A., 81: 6447.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Smith, R., III, and Rich, R.R., 1985. Polymorphism and tissue distribution of maternally transmitted antigen defined by cytotoxic T lymphocyte lines. J. Immunol., 134: 2191.

    PubMed  Google Scholar 

  • Smith, R., III, Huston, M.M., Jenkins, R.N., Huston, D.P., and Rich, R.R., 1983. Mitochondria control expression of a murine cell surface antigen. Nature, 306: 599.

    Article  PubMed  CAS  Google Scholar 

  • Steinmetz, M., Frelinger, J.G., Fisher, D., Hunkapillar, T., Pereira, D., Weissman, S.M., Uehara, H., Nathenson, S., and Hood, L., 1981. Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes. Cell, 24: 125.

    Article  PubMed  CAS  Google Scholar 

  • Townsend, A.R.M., Rothbard, J., Gotch, F.M., Bahadur, G., Wraith, D., and McMichael, A.J., 1986. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell, 44: 959.

    Article  PubMed  CAS  Google Scholar 

  • Yonekawa, H., and Fischer Lindahl, K., 1987. Searching for the molecular basis of a mitochondrial transplantation antigen. Genetics, 116: s41.

    Google Scholar 

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Departments of Microbiology and Biochemistry, University of Texas Health Science Center at Dallas, Dallas, Texas, 75235-9050, USA

    Kirsten Fischer Lindahl, Bruce E. Loveland & C. Sue Richards

Authors
  1. Kirsten Fischer Lindahl
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  2. Bruce E. Loveland
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  3. C. Sue Richards
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Editors and Affiliations

  1. Mayo Clinic, Rochester, Minnesota, USA

    Chella S. David Ph.D.

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© 1987 Springer Science+Business Media New York

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Lindahl, K.F., Loveland, B.E., Richards, C.S. (1987). The End of H-2 . In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_33

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  • DOI: https://doi.org/10.1007/978-1-4757-0764-9_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0766-3

  • Online ISBN: 978-1-4757-0764-9

  • eBook Packages: Springer Book Archive

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