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H-2 Antigens pp 327-338 | Cite as

The End of H-2

  • Kirsten Fischer Lindahl
  • Bruce E. Loveland
  • C. Sue Richards
Chapter
Part of the NATO ASI Series book series (NSSA, volume 144)

Abstract

Mta, the maternally transmitted antigen of mice, was discovered and its analysis was pursued because it seemingly had nothing to do with H-2. Immunization of NZB/B1NJ mice with H-2-compatible BALB/c cells gave rise to cytotoxic T lymphocytes (CTL) that killed target cells of more than eighty strains of mice, independent of their H-2 type. Cold target competition showed that they all shared one antigen, and it was hard to find a strain whose cells were not lysed (Fischer Lindahl et al. 1980). Mta was thus a clear exception to the rule that CTL are H-2-restricted, i.e. recognize their target antigens in association with one of the class I major histocompatibility antigens (MHC I), H-2K, H-2D and H-2L. Obviously, we were not dealing with a rare case of MHC II-restricted CTL either.

Keywords

Congenic Strain Histocompatibility Antigen Wild Mouse Restriction Element Kill Target Cell 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Kirsten Fischer Lindahl
    • 1
  • Bruce E. Loveland
    • 1
  • C. Sue Richards
    • 1
  1. 1.Howard Hughes Medical Institute and Departments of Microbiology and BiochemistryUniversity of Texas Health Science Center at DallasDallasUSA

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