H-2 Antigens pp 321-325 | Cite as

Cloning of a Testis-Specific Gene Located Between Qa-2 and Upg-1 on Mouse Chromosome 17

  • Masanori Kasahara
  • Felipe Figueroa
  • Jan Klein
Part of the NATO ASI Series book series (NSSA, volume 144)


The t complex of the mouse is a large genetic region occupying proximal one third of chromosome 17. Mutant forms of this region, known as t haplotypes, show several unique properties such as segregation distortion, male sterility, embryonic lethality, and suppression of crossing-over (for review, see Silver 1985, Klein 1986). Recently, several investigators have demonstrated that t haplotypes have two non-overlapping inversions relative to their non-t counterparts, thus accounting for the observed suppression of crossing-over between t and non-t haplotypes (Artzt et al. 1982, Pla and Condamine 1984, Herrmann et al. 1986). However, precise mechanisms underlying segregation distortion, male sterility, and embryonic lethality remain poorly understood because of lack of available information at the molecular level.


Male Sterility Mouse Chromosome Restriction Fragment Length Polymorphism Pattern Congenic Mouse Cosmid Clone 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Masanori Kasahara
    • 1
  • Felipe Figueroa
    • 2
  • Jan Klein
    • 1
    • 2
  1. 1.Department of Microbiology and ImmunologyUniversity of Miami School of MedicineMiamiUSA
  2. 2.Department of ImmunogeneticsMax Planck Institute for BiologyTubingen 1Federal Republic of Germany

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