Abstract
The t complex of the mouse is a large genetic region occupying proximal one third of chromosome 17. Mutant forms of this region, known as t haplotypes, show several unique properties such as segregation distortion, male sterility, embryonic lethality, and suppression of crossing-over (for review, see Silver 1985, Klein 1986). Recently, several investigators have demonstrated that t haplotypes have two non-overlapping inversions relative to their non-t counterparts, thus accounting for the observed suppression of crossing-over between t and non-t haplotypes (Artzt et al. 1982, Pla and Condamine 1984, Herrmann et al. 1986). However, precise mechanisms underlying segregation distortion, male sterility, and embryonic lethality remain poorly understood because of lack of available information at the molecular level.
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Kasahara, M., Figueroa, F., Klein, J. (1987). Cloning of a Testis-Specific Gene Located Between Qa-2 and Upg-1 on Mouse Chromosome 17. In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_32
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DOI: https://doi.org/10.1007/978-1-4757-0764-9_32
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