Abstract
The search for specific genes in chromosomal regions implicated in particular diseases or associated with certain functions is one of the approaches that may lead to a molecular analysis of inherited albeit biochemically ill defined traits. This strategy is presently pursued to understand the mechanism of some genetically determined diseases such as the Duchenne Muscular Dystrophy (Monaco et al., 1986).
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Amor, M., Tosi, M., Duponchel, C., Steinmetz, M., and Mea, T.: Liver mRNA probes disclose two cytochrome P-450 genes duplicated in tandem with the complement C4 loci of the mouse H-2S region. Proc. Natl. Acad. Sci. USA 82: 4453, 1985
Bird, A.P.: CpG-rich islands and the function of DNA methylation. Nature 321: 209, 1986
Burke, T., and Bruford, M.W.: DNA fingerprinting in birds. Nature 327: 149, 1987
Carroll, M.C., Campbell, R.D., Bentley, D.R., and Porter, R.R.: A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B. Nature 307: 237, 1984
Chaplin, D., Woods, D., Whitehead, A., Goldberger, G., Colten, H.R., and Seidman, J.G.: Molecular map of the murine S region. Proc. Natl. Acad. Sci. USA 80: 6947, 1983
Estivill, X., Farrall, M., Scambler, P.J., Bell, G.M., Hawley, K.M.F., Lench, N.J., Bates, G.P., Kruger, H.C., Frederick, P.A., Stanier, P., Watson, E.K., Williamson, R., and Wainwright, B.S.: A candidate for the cystic fibrosis locus isolated by selection for methylationfree islands. Nature 326: 840, 1987
Feinberg, A.P., and Vogelstein, B.: A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Analytical Biochemistry 132: 6, 1983
Friend, S.H., Bernards, R., Rogelj, S., Weinberg, R.A., Rappaport, J.M., Albert, D.M., and Dryja, T.P.: A human DNA segment with properties of the gene that predisposes to retinoblastoma and oasteosarcoma. Nature 323: 643, 1986
Grosveld, F.G., Lund, T., Murray, E.J., Mellor, A.L., Dahl, H.H.M., and Flavell, R.A.: The construction of cosmid libraries which can be used to transform eukaryotic cells. Nucl. Ac. Res. 10: 6715, 1982
Jeffreys, A.J., Wilson, V., and Thein, S.L.: Hypervariable “minisatellite” regions in human DNA. Nature 314: 67, 1985
Juji, T., Satake, M., Honda, Y., and Doi, Y.: HLA antigens in Japanese patients with narcolepsy. Tissue Antigens 24: 316, 1984
Lemonnier, F.A., Malissen, M., Goldstein, P., Le Bouteiller, P., Rebai, N., Damotte, M., Birnbaum, D., Caillol, D., Trucy, J., and Jordan, B.R.: Expression of human class I histocompatibility antigens at the surface of DNA transformed mouse L cells. Immunogenetics 16: 355, 1982
Lévi-Strauss, M., Tosi, M., Steinmetz, M., Klein, J., and Meo, T.: Multiple duplications of complement C4 gene correlate with H-2 controlled testosterone-independent expression of its sex-limited isoform, C4-Slp. Proc. Natl. Acad. Sci. USA 82: 1746, 1985a
Lévi-Strauss, M., Georgatsou, E., Tosi, M., and Meo, T.: Gene-specific probes demonstrate selective duplications of the C4-Slp gene. Immunogenetics 21: 397, 1985b
Lindsay, S., and Bird, A.P.: Use of restriction enzymes to detect potential gene sequences in mammalian DNA. Nature 327: 336, 1987
Mallat, M., Moura Neto, V., Gros, F., Glowinski, J., and Prochiantz, A.: Two simian virus 40 (SV40) transformed cell lines from the mouse striatum and mesencephalon presenting astrocytes characters. II: Interaction with mesencephalic neurons. Dev. Brain Res. 26: 23, 1986
Monaco, A.P., Neve, R.L., Colletti-Feener, C., Bertelson, C.J., Kurnit, D.M., and Kunkel, L.M.: Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy gene. Nature 323: 646, 1986
Miller, U., Stephan, D., Philippsen, P., and Steinmetz, M.: Orientation and molecular map position of the complement genes in the mouse MHC. EMBO J. 6: 369, 1987
Parker, K.L., Chaplin, D.D., Wong, M., Seidman, J.G., Smith, J.A., and Schimmer, B.P.: Expression of murine 21-hydroxylase in mouse adrenal glands and in transfected Y1 adrenocortical tumor cells. Proc. Natl. Acad. Sci. USA 82: 7860, 1985
Simon, M., Fauchet, R., Hespel, J.P., Beaumont, C., Brissot, P., Hita de Nercy, Y., Genetet, B., and Bourel, M.: Idiopathic homochromatosis, a study of biochemical expression in 247 heterozygous members of 63 families. Evidence for a single major HLA-linked gene. Gastroenterology 78: 703, 1980
Steimetz, M., Malissen, M., Hood, L., Orn, A., Maki, R.A., RezaDastoornikoo, G., Stephan, D., Gibb., E., and Romaniuk, R.: Tracts of high or low sequence divergence in the mouse major histocompatibility complex. EMBO J. 3: 2995, 1984
Tosi, M., Lévi-Strauss, M., Georgatsou, E., Amor, M., and Meo, T.: Duplications of complement and non complement genes of the H-2S region: evolutionary aspects of C4 isotypes and molecular analysis of their expression variants. Immunological Reviews 87: 151, 1985
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Lévi-Strauss, M., Carroll, M., Steinmetz, M., Meo, T. (1987). Probing MHC DNA in Search of Coding Sequences: Detection of a Novel Gene Located Between C4 and Bf in Mouse and Man. In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_30
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DOI: https://doi.org/10.1007/978-1-4757-0764-9_30
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