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H-2 Antigens pp 245–253Cite as

Structural and Functional Analysis of Murine Class II Molecules

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Part of the book series: NATO ASI Series ((NSSA,volume 144))

Abstract

Class II (Ia) major histocompatibility complex (MHC) molecules in the mouse are cell surface glycoproteins expressed on antigen presenting cells (APC; ref. 1). In the mouse two isotypic forms of Ia exist: the I-A and I-E molecules, each a heterodimer composed of noncovalently-associated a and ß chains. The association of foreign antigen, Ia molecules and the clonally distributed antigen receptor on T cells is critical in the initiation and regulation of immune responses1. However, the exact nature of the interaction between T cell receptor, antigen and Ia molecule is still poorly understood at the molecular level.

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Author information

Authors and Affiliations

  1. Department of Cancer Biology, Harvard School of Public Health, USA

    Irwin J. Griffith & Laurie H. Glimcher

  2. Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA

    Laurie H. Glimcher

Authors
  1. Irwin J. Griffith
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  2. Laurie H. Glimcher
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Editor information

Editors and Affiliations

  1. Mayo Clinic, Rochester, Minnesota, USA

    Chella S. David Ph.D.

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© 1987 Springer Science+Business Media New York

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Griffith, I.J., Glimcher, L.H. (1987). Structural and Functional Analysis of Murine Class II Molecules. In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_24

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  • DOI: https://doi.org/10.1007/978-1-4757-0764-9_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0766-3

  • Online ISBN: 978-1-4757-0764-9

  • eBook Packages: Springer Book Archive

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