H-2 Antigens pp 233-244 | Cite as

Biochemical and Molecular Characterization of Q-Region Class I Gene Products

  • Mark J. Soloski
  • Gregory P. Einhorn
  • Leroy Hood
  • Iwona Stroynowski
Part of the NATO ASI Series book series (NSSA, volume 144)


Telomeric to the H2D region is a chromosomal segment which encodes several serologically and/or biochemically defined class I molecules (1). These include the cell surface molecules Qal, Qa2 and TL and the soluble proteins Qbl and Q10 (2–4). Although related to H2-K, -D, -L molecules by subunit structure and primary sequence, the Qa/TL molecules are biologically distinct. For example, Qa/TL molecules display distinct tissue specific regulated expression, are relatively nonpolymorphic (conserved ?) and appear not to be utilized as restricting elements in T cell recognition. Although their class I counterparts H2-K, -D and -L have well defined roles in tissue/organ transplantation and T cell recognition of foreign antigens, the function(s) of the Qa/TL class I proteins remains obscure.


Major Histocompatibility Complex Decay Accelerate Factor Transplantation Antigen Lipase Treatment Detergent Phase 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Mark J. Soloski
    • 1
    • 2
  • Gregory P. Einhorn
    • 1
    • 2
  • Leroy Hood
  • Iwona Stroynowski
  1. 1.Subdepartment of Immunology, Department of Molecular Biology and GeneticsJohns Hopkins School of MedicineBaltimoreUSA
  2. 2.The Division of BiologyCalifornia Institute of TechnologyPasadenaUSA

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