Abstract
Once molecular probes detecting mouse H-2 (Kvist et al., 1981) and human HLA (Ploegh et al., 1980; Sood et al., 1981) class I sequences had been isolated, it was quickly realized that the mouse class I H-2 multigene family was far more complex than initially anticipated (Cami et al., 1981; Steinmetz et al., 1981a). A considerable amount of cloning work performed in several laboratories has led to the isolation of almost the entire H-2 locus from both BALB/c (Steinmetz et al., 1982) and B10 mice (Weiss et al., 1984). These studies have established that there exists of the order of 26 to 36 class I H-2 genes, depending on the mouse strain. It has become usual to divide these genes into two major groups predominantly on the basis of serological data. The first group includes those genes which map to the K and D loci. They encode the quasi-ubiquitous and highly polymorphic class -I major transplantation antigens, which serve as restriction elements in the recognition of target cells by cytotoxic T lymphocytes (Zinckernagel and Doherty, 1979; see also Kourilsky et al., 1987). The other group of genes (23 to 29 depending on the mouse strain) lie in the Qa-Tla region and includes the genes encoding the serologically detected Qa and Tla differentiation cell surface antigens. The latter are much less polymorphic than. the class I molecules encoded in the K and D regions, and display a limited tissue distribution, being expressed mostly in B and/or T cells. Accordingly, it was believed for some time that the Qa-Tla region encoded only non-ubiquitous cell surface antigens.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Archibald, A.L., Thompson, N.A., and Kvist, S., 1986, A single nucleotide difference at the 3’ end of an intron causes differential splicing of two histocompatibility genes, EMBO J, 5: 957.
Arnold, B., Horstmann, U., Kuon, B., Burgert, H.G., Hämmerling, G.J., and Kvist, S., 1985, Alloreactive cytolytic T-cell clones preferentially recognize conformational determinants on histocompatibility antigens: analysis with genetically engineered hybrid antigens, Proc. Natl. Acad. Sci., USA, 82: 7030.
Barclay, A.N., Johnson, P., McCaughan, G.W., and Williams, A.F., 1987, Immunoglobulin-related structures associated with vertebrates cell surfaces, in: “Ann. Rev. Immunol.”, T. Mak, Ed., in press.
Brickell, P.M., Latchman, D.S., Murphy, D., Willison, K., and Rigby, P.W.J., 1983, Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse, Nature, 306: 756.
Brickell, P.M., Latchman, D.S., Murphy, D., Willison, K., and Rigby, P.W.J., 1985, The class I major histocompatibility antigen gene activated in a line of SV40-transformed mouse cells in H-2Dd, not Qa/Tla, Nature, 316: 162.
Burgert, H.-G., and Kvist, S., 1985, An adenovirus type 2 glycoprotein block cell surface expression of human histocompatibility class I antigens, Cell, 41: 987.
Cami, B., Brégégère, F., Abastado, J.-P., and Kourilsky, P., 1981, Multiple sequences related to classical histocompatibility antigens in the mouse genome, Nature, 291: 673.
Cochet, M., Kast, W.M., Kummer, A.-M., Transy, C., Melief, C.J.M., and Kourilsky, P., 1986, Alternative splicing in the mouse H-2Kd gene is not necessary for the classical Kd antigen function, Immunogenetics, 24: 267.
Cosman, D., Kress, M., Khoury, G., and Jay, G., 1982, Tissue specific expression of an unusual H-2 class I related gene, Proc. Natl. Acad. Sci., USA, 79: 4947.
Démant, P., and Ivànyi, D., 1981, Further molecular complexities of H-2Kand D-regions antigens, Nature, 290: 146.
Fisher, D.A., Hunt, S.W., III, and Hood, L.E., 1985, Structure of a gene encoding a murine thymus leukemia antigen and organization of Tla genes in the BALB/c mouse, J. Exp. Med., 162: 528.
Haas, I.G., and Wabl, M., 1983, Immunoglobulin heavy chain binding protein, Nature, 306: 387.
Hansen, T.H., Ozato, K., and Sachs, D., 1983, Heterogeneity of H-2D region associated genes and gene products, Adv. Immunol., 34: 39.
Israël, A., Kimura, A., Fournier, A., Fellous, M., and Kourilsky, P., 1986; Interferon response sequence potentiates activity of an enhancer in the promotor region of a mouse H-2 gene, Nature, 322: 743.
Israël, A., Kimura, A., Kieran, M., Yano, O., Kanellopoulos, J., Le Bail, O., and Kourilsky, P., 1987, A common positive trans-acting factor binds to enhancer-sequences in the promotors of mouse H-2 and beta-2microglobulin genes, Proc. Natl. Acad. Sci., USA, 84: 2653.
Jaulin, C., Perrin, A., Abastado, J.-P., Dumas, B., Papamatheakis, J., and Kourilsky, P., 1985, Polymorphism in mouse and human class I H-2 and HLA genes is not the result of random independent point mutations, Immunogenetics, 22: 453.
Kimura, A., Israél, A., Le Bail, O., and Kourilsky, P., 1986, Detailed analysis of the mouse H-2Kb promoter: enhancer-like sequences and their role in the regulation of class I gene expression, Cell, 44: 261.
Kourilsky, P., 1986, Molecular mechanisms for gene conversion in higher cells, Tr. Gen., 2: 60.
Kourilsky, P., Chaouat, G., Rabourdin-Combe, C., and Claverie, J.-M., 1987, Working principles in the immune system implied by the “peptidic self” model, Proc. Natl. Acad. Sci., USA, 84: 3400.
Kress, M., Glaros, D., Khoury, G., and Jay, G., 1983a, Alternative RNA splicing in expression of the H-2K gene, Nature, 306: 602.
Kress, M., Cosman, D., Khoury, G., and Jay, G., 1983b, Secretion of a transplantation-related antigen, Cell, 34: 186.
Kress, M., Barra, Y., Seidman, J.G., Khoury, G., and Jay, G., 1984, Functional insertion of an alu type 2 ( B2 SINE) repetitive sequence in murine class I genes, Science, 226: 974.
Krieg, P.A., and Melton, D.A., 1984, Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs, Nucl. Acids Res., 12: 7057.
Kvist, S., Brégégère, F., Rask, L., Cami, B., Garoff, H., Daniel, F., Wiman, K., Larhamar, D., Abastado, J.P., Gachelin, G., Peterson, P.A., Dobberstein, B., and Kourilsky, P., 1981, A cDNA clone coding for part of a mouse H-2d major histocompatibility antigen, Proc. Natl. Acad. Sci., USA, 78: 2772.
Lalanne, J.L., Cochet, M., Kummer, A.M., Gachelin, G. and Kourilsky, P., 1983a, Different exon-intron organization at the 5’ part of a mouse class I gene is used to generate a novel H-2Kb-related mRNA, Proc. Natl. Acad. Sci., USA, 80: 7561.
Lalanne, J.L., Delarbre, C., Gachelin, G., and Kourilsky, P., 1983b, A cDNA clone containing the entire coding sequence of a mouse H-2Kd histocompatibility antigen, Nucl. Acids Res., 11: 1567.
Lalanne, J.L., Transy, C., Guérin, S., Darche, S., Meulien, P., and Kourilsky, P., 1985, Expression of class I genes in the major histo-compatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver, Cell, 41: 469.
Lew, A.M., Margulies, D.H., Maloy, W.L., Lillehoj, E.P., McCluskey, J., Coligan, J.E., 1986a, Alternative protein products with different carboxyl termini from a single class I gene H-2Kb, Proc. Natl. Acad. Sci., USA, 83: 6084.
Lew, A.M., Maloy, W.L., and Coligan, J.E., 1986b, Characteristics of the expression of the murine soluble class I molecule (Q10), J. Immunol., 136: 254.
Miyazaki, J.-I., Appella, E., and Ozato, K., 1986, Negative regulation of the major histocompatibility class I gene in undifferentiated embryonal carcinoma cells, Proc. Natl. Acad. Sci., USA, 83: 9537.
Momburg, F., Koch, N., Möller, P., Moldenhauer, G., and Hämmerling, G.J., 1986, In vivo induction of H-2K/D antigens by recombinant interferon-gamma, Eur. J. Immunol., 16: 551.
Moore, K.W., Sher, B.T., Sun, Y.H., Eakle, K.A., and Hood, L.E., 1982, DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen, Science, 215: 679.
Munro, S., and Pelham, H.R.B., 1986, An Hsp-70 like protein in the ER: identity with the 78 kd glucose regulated protein and immunoglobulin heavy chain binding protein, Cell, 46: 291.
Ozato, K., Mayer, N.M., and Sachs, D.H., 1982, Monoclonal antibodies to mouse major histocompatibility complex antigens. IV A series of hybridoma clones producing anti-H-2d antibodies and an estimation of expression of H-2d antigens on the surface of these cells, Transplantation, 34: 113.
Pääbo, S., Nilson, T., and Peterson, P.A., 1986, Adnovirus of subgeneria B, C, D and E modulate cell-surface expression of major his tocompatibility complex class I antigens, Proc. Natl. Acad. Sci., USA, 83: 9665.
Ploegh, H.L., Orr, H.T., and Strominger, J.L., 1980, Molecular cloning of a human histocompatibility antigen cDNA fragment, Proc. Natl. Acad. Sci., USA, 77: 6081.
Pontarotti, P.A., Mashino, H., Zeff, R.A., Fisher, D.A., Hood, L., Mellor, A., Flavell, R.A., and Nathenson, S.G., 1986, Conservation and diversity in the class I genes of the major histocompatibility complex: sequence analysis of a Tlab gene and comparison with a Tlac gene, Proc. Natl. Acad. Sci., USA, 83: 1782.
Reyes, A.A., Schöld, M., Itakura, K., and Wallace, B., 1982a, Isolation of a cDNA clone for the murine transplantation antigen H-2Kb, Proc. Natl. Acad. Sci., USA, 79: 3270.
Reyes, A.A., Schöld, M., and Wallace, R.B., 1982b, The complete amino acid sequence of the murine transplantation antigen H-2Dd as deduced by molecular cloning, Immunogenetics, 16: 1.
Rodgers, M.J., Siwarski, D.F., Shacter, E., Maloy, W.L., Lillehoj, E.P., and Coligan, J.E., 1986, Three distinct H-2Ks molecules differing at the carboxy terminus are expressed on a tumor from SJL/J mice, J. Immunol., 137: 3006.
Sher, B.T., Nairn, R., Coligan, J.E., and Hood, L.E., 1985, DNA sequence of the mouse H-2Dd transplantation antigen gene. Proc. Natl. Acad. Sci., USA, 82: 1175.
Sood, A.K., Pereira, D., and Weissman, S.M., 1981, Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primer, Proc. Natl. Acad. Sci., USA, 78: 616.
Stein, P., Barra, Y., Jay, G., and Strickland, S., 1986, Expression of a secreted transplantation antigen during murine embryogenesis, Mol. Cell. Biol., 6: 3397.
Steinmetz, M., Frelinger, J.G., Fisher, G., Hunkapiller, T., Pereira, D., Weissman, S.M., Uehara, H., Nathenson, S., and Hood, L., 1981a, Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes, Cell, 24: 125.
Steinmetz, M., Moore, K.W., Frelinger, J.G., Sher, B.T., Shen, F.W., Boyse, E.A., and Hood, L., 1981b, A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domain, Cell, 25, 683.
Steinmetz, M., Moore, K.W., Frelinger, J.G., Sher, B.T., Shen, F.W., Boyse, E.A., and Hood, L., 1981b, A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domain, Cell, 25, 683.
Steinmetz, M., Winoto, A., Minard, K., and Hood, L.E., 1982, Clusters of genes encoding transplantation antigens, Cell, 28: 489.
Stephan, D., Sun, H., Fisherlindahl, K., Meyer, E., Hämmerling, G., Hood, L., and Steinmetz, M., 1986, Organization and evolution of D region class I genes in the mouse major histocompatibility complex, J. Exp. Med., 163: 1227.
Strubin, M., Long, E.O., and Mach, B., 1986, Two forms of the Ia antigens associated invariant chain result from alternative initiations at two in-phase AUGs, Cell, 47: 619.
Transy, C., Lalanne, J.L., and Kourilsky, P., 1984, Alternative splicing in the 5’ moiety of the H-2Kd gene transcript, EMBO J., 3: 2383.
Transy, C., Nash, R.S., David-Watine, B., Cochet, M., Hunt, S.W., III, Hood, L.E., and Kourilsky, P., 1987, A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types, J. Exp. Med., 166: 341.
Tryphonas, M., King, D.P., and Jones, P.P., 1983, Identification of a second class I antigen controlled by the K end of the H-2 complex and its selective cellular expression, Proc. Natl. Acad. Sci., USA, 80: 1445.
Waneck, G.L., Sherman, D.H., Calvin, S., Allen, H., and Flavell, R.A., 1987, Tissue-specific expression of cell-surface Qa-2 antigen from a transfected Q7b gene of C57B1/10 mice, J. Exp. Med., 165: 1358.
Weiss, E.M., Golden, L., Fahrner, K., Mellor, A.L., Devling, J.J., Bullman, H., Tiddens, H., Bud, H., and Flavell, R.A., 1984, Organization and evolution of class I gene family in the major histocompatibility complex of the C57B1/10 mouse, Nature, 310: 650.
Yakoyama, E., Shiku, H., Stockert, E., Oettgen, H.F., and Old, L.J., 1979, Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera, Proc. Natl. Acad. Sci., USA, 76: 1977.
Zinkernagel, R.M., and Doherty, P.C., 1979, MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction specificity, function, and responsiveness, Adv. Immunol., 27: 52.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer Science+Business Media New York
About this chapter
Cite this chapter
Cochet, M. et al. (1987). Complex Expression of the Mouse H-2 Class I Genes. In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_22
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0764-9_22
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0766-3
Online ISBN: 978-1-4757-0764-9
eBook Packages: Springer Book Archive