Complex Expression of the Mouse H-2 Class I Genes
Once molecular probes detecting mouse H-2 (Kvist et al., 1981) and human HLA (Ploegh et al., 1980; Sood et al., 1981) class I sequences had been isolated, it was quickly realized that the mouse class I H-2 multigene family was far more complex than initially anticipated (Cami et al., 1981; Steinmetz et al., 1981a). A considerable amount of cloning work performed in several laboratories has led to the isolation of almost the entire H-2 locus from both BALB/c (Steinmetz et al., 1982) and B10 mice (Weiss et al., 1984). These studies have established that there exists of the order of 26 to 36 class I H-2 genes, depending on the mouse strain. It has become usual to divide these genes into two major groups predominantly on the basis of serological data. The first group includes those genes which map to the K and D loci. They encode the quasi-ubiquitous and highly polymorphic class -I major transplantation antigens, which serve as restriction elements in the recognition of target cells by cytotoxic T lymphocytes (Zinckernagel and Doherty, 1979; see also Kourilsky et al., 1987). The other group of genes (23 to 29 depending on the mouse strain) lie in the Qa-Tla region and includes the genes encoding the serologically detected Qa and Tla differentiation cell surface antigens. The latter are much less polymorphic than. the class I molecules encoded in the K and D regions, and display a limited tissue distribution, being expressed mostly in B and/or T cells. Accordingly, it was believed for some time that the Qa-Tla region encoded only non-ubiquitous cell surface antigens.
KeywordsTransplantation Antigen Major Histocompatibility Antigen Mouse Major Histocompatibility Complex Human Histocompatibility Immunoglobulin Heavy Chain Binding Protein
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