Abstract
Major histocompatibility complex (MHC) class I antiens are highly polymorphic proteins expressed on the surface of most murine cells. These glycoproteins have a molecular weight of 37–45,000 daltons and are noncovalently associated with the nonpolymorphic β2-microglobulin light chain. The classical transplantation antigens H-2K, -D, and -L serve as restriction elements for viral and tumor antigens and thereby allow the specific recognition of target cells by cytotoxic T lymphocytes (CTL).
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Hedley, M.L., Tucker, P., Forman, J. (1987). Mutation of the Splice Acceptor Sites at the 5’End of Exon 2 of H-2Kd and H-2Dd Results in the Expression of Altered Class I Antigens Expressed on the Membrane of L Cells. In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_21
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DOI: https://doi.org/10.1007/978-1-4757-0764-9_21
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