H-2 Antigens pp 209-218 | Cite as

Mutation of the Splice Acceptor Sites at the 5’End of Exon 2 of H-2Kd and H-2Dd Results in the Expression of Altered Class I Antigens Expressed on the Membrane of L Cells

  • Mary Lynne Hedley
  • Philip Tucker
  • James Forman
Part of the NATO ASI Series book series (NSSA, volume 144)


Major histocompatibility complex (MHC) class I antiens are highly polymorphic proteins expressed on the surface of most murine cells. These glycoproteins have a molecular weight of 37–45,000 daltons and are noncovalently associated with the nonpolymorphic β2-microglobulin light chain. The classical transplantation antigens H-2K, -D, and -L serve as restriction elements for viral and tumor antigens and thereby allow the specific recognition of target cells by cytotoxic T lymphocytes (CTL).


Alternative Splice Splice Site P815 Cell Acceptor Site Acceptor Splice Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Mary Lynne Hedley
    • 1
  • Philip Tucker
    • 1
  • James Forman
    • 1
  1. 1.University of Texas Health Science Center at DallasDallasUSA

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