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Peter Gorer Could Discover the H-2 Complex by Naturally Occurring Human Antibodies

  • P. Ivanyi
  • T. Kloosterman
Part of the NATO ASI Series book series (NSSA, volume 144)

Summary

Human sera, exceptionally, do contain lymphocytotoxic antibodies which detect polymorphic mouse lymphocyte membrane antigens whose expression is controled by the H-2 complex. In accordance with the original plans of Gorer, mouse transplantation antigens, namely the H-2 system, might have been discovered by naturally occurring human antibodies.

Keywords

Blood Group Human Antibody Human Seron Progeny Testing Congenic Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Gorer, P.A.: The detection of a hereditary antigenic difference in the blood of mice by means of human group A serum. J. Genetics, 32: 17–31, 1936.CrossRefGoogle Scholar
  2. Ivanyi, P., Leupers, T., Mourik, P. van,: Naturally occurring cytotoxic human antibodies recognize H-2 controlled murine lymphocytotoxic antigens. Proc.Ndt.ANad.Soti.USA, 80: 4479–4483, 1983.CrossRefGoogle Scholar
  3. Klein, J.: Natural History of the Major Histocompatibility Complex. J. Wiley and Sons New York, 198, 1968.Google Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • P. Ivanyi
    • 1
  • T. Kloosterman
    • 1
  1. 1.Central Laboratory of the Netherlands Red Cross Blood Transfusion ServiceLaboratory for Experimental and Clinical Immunology of the University of AmsterdamAmsterdamThe Netherlands

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