H-2 Antigens pp 133-138 | Cite as

Some Recent Data on the Q-Subregion Genes and Their Products

  • Lorraine Flaherty
Part of the NATO ASI Series book series (NSSA, volume 144)


For the last ten years we have concentrated our studies on the Q genes of the murine major histocompatibility complex (MHC). These genes determine a series of class I molecules which are 80–90% homologous to the more classical H-2K and H-2D genes. Because of this homology, we have frequently hypothesized that these genes have an important function in the immune system. However, recent data showing large deletions in the Q subregion, without any overt effects on survival, have cast some doubt on this hypothesis.


Major Histocompatibility Complex Congenic Strain Inositol Trisphosphate Variant Surface Glycoprotein Preimplantation Mouse Embryo 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Lorraine Flaherty
    • 1
  1. 1.Wadsworth Center for Laboratories and ResearchNew York State Department of HealthAlbanyUSA

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