Some Recent Data on the Q-Subregion Genes and Their Products
For the last ten years we have concentrated our studies on the Q genes of the murine major histocompatibility complex (MHC). These genes determine a series of class I molecules which are 80–90% homologous to the more classical H-2K and H-2D genes. Because of this homology, we have frequently hypothesized that these genes have an important function in the immune system. However, recent data showing large deletions in the Q subregion, without any overt effects on survival, have cast some doubt on this hypothesis.
KeywordsMajor Histocompatibility Complex Congenic Strain Inositol Trisphosphate Variant Surface Glycoprotein Preimplantation Mouse Embryo
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