H-2 Antigens pp 125-132 | Cite as

Involvement of the H-2 Complex in Steroid Hormone Metabolism

  • Marika Pla
  • Anna Rocca
  • Daniel Gillet
  • Jean-Marie Villette
  • Jean Fiet
  • Laurent Degos
Part of the NATO ASI Series book series (NSSA, volume 144)

Abstract

We investigated DNA from mice with different H-2 haplotypes (b. d., f, j, k, p, g, r, s, u, v,). DNA was digested with five restriction enzymes (Eco RI, Taq I, Pvu II, Hind III, and Bgl II) and probed with human 21-OHase cDNA clone. Combined restriction fragment length polymorphism identify six different patterns of endonuclease fragment polymorphism of the murine 21-OHase region. Furthermore, we have investigated the serum level of two steroid hormones (progesterone and corticosterone) in the metabolic pathway involving the 21-OHase. Serum progesterone and corticosterone concentrations exhibit variations according to the H-2 haplotypes of the mice, suggesting that genetic factor(s) identical to or closely linked to the H-2 complex is involved in the control of their metabolism.

Keywords

Major Histocompatibility Complex Folia Biol Serum Progesterone Concentration Major Histocompatibility Complex Restriction Serum Corticosterone Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Marika Pla
    • 1
  • Anna Rocca
    • 1
  • Daniel Gillet
    • 1
  • Jean-Marie Villette
    • 2
  • Jean Fiet
    • 2
  • Laurent Degos
    • 1
  1. 1.U 93 INSERMHôpital St. LouisParisFrance
  2. 2.Laboratoire de PharmacieHôpital St. LouisParisFrance

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