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Guanidines pp 49–58Cite as

Developmental Changes in Guanidino Compounds Levels in Mouse Organs

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Abstract

Many kinds of guanidino compounds are known to be existent in mammalian organsl, and they are thought to be related to nitrogen metabolism. There have been many reports of guanidino compound levels in human body fluids and animal organs changing under various pathological conditions. Methylguanidine (MG) and guanidinosuccinic acid (GSA) in serum are elevated in uremic patients2,3. Increased excretion of α-keto-δ-guanidinovaleric acid in urine was observed in patients with hyperargininaemia4. High concentrations of taurocyamine in the cerebrospinal fluid of some epileptic patients have been observed5. Yokoi et al.6,7 showed the homoarginine (HArg) level to be high in liver, kidney and serum of rats administered alcohol chronically. These observations suggest that guanidino compound levels in organs may change according to physiological conditions. It is possible that the levels of guanidino compounds may also change during maturation when physiological conditions are thought to be undergoing change. The data reported herein are the results of a study of developmental changes in the levels of guanidino compounds in mouse organs.

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Authors and Affiliations

  1. Department of Neurochemistry, Institute for Neurobiology, Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700, Japan

    Yoko Watanabe, Shoichiro Shindo & Akitane Mori

Authors
  1. Yoko Watanabe
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  2. Shoichiro Shindo
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  3. Akitane Mori
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Editor information

Editors and Affiliations

  1. Inst. for Neurobiology, Okayama University Medical School, Okayama 700, Japan

    Akitane Mori

  2. The Bronx Lebanon Hospital Center, Bronx, New York, USA

    B. D. Cohen

  3. Laboratory of Neurochemistry, Born-Bunge Foundation, Universitaire Instelling Antwerpen, 2610, Wilrijk, Belgium

    A. Lowenthal

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© 1985 Springer Science+Business Media New York

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Watanabe, Y., Shindo, S., Mori, A. (1985). Developmental Changes in Guanidino Compounds Levels in Mouse Organs. In: Mori, A., Cohen, B.D., Lowenthal, A. (eds) Guanidines. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0752-6_5

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  • DOI: https://doi.org/10.1007/978-1-4757-0752-6_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0754-0

  • Online ISBN: 978-1-4757-0752-6

  • eBook Packages: Springer Book Archive

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