Metabolic Changes of Guanidino Compounds in Acute Renal Failure Complicated with Hepatic Disease
Acute uremia may be associated with increased arginine (ARG) utilization and increased synthesis of urea. Perez et al.1 demonstrated an increased synthesis of guanidinosuccinic acid (GSA) by livers of acutely uremic rats. We found clinical evidence that in actual cases of acute renal failure (ARF) complicated with hepatic disease, concentrations of guanidino compounds (GC) vary from those seen in ARF without hepatic disease.2 The present study was designed to examine the metabolic relationship of liver to kidney and to investigate the effect of renal and hepatic function on the metabolism of ARG and other urea cycle intermediates. In this study, we compare GC concentrations in ARF without hepatic disease with those in ARF with hepatic disease by the use of guanidinograms, which are circle diagrams composed of eight GC.
KeywordsAcute Renal Failure Hepatic Disease Carbamyl Phosphate Urea Cycle Enzyme Ornithine Carbamoyltransferase
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