Skip to main content
SpringerLink
Log in

A Study of Creatine Metabolism in Chronic Renal Failure Rats

  • Chapter
Book cover Guanidines

  • 80 Accesses

Abstract

Creatine is formed by the methylation of guanidinoacetic acid (GAA). GAA is formed from arginine and glycine in a reaction catalyzed by glycine amidinotransferase (GAT). In chronic uremic subjects, the creatine level is increased in the plasma and normal in the urine1,2. The cause of the elevated creatine is not entirely clear. Serum GAA levels are elevated and GAA in the urine is decreased in renal failurel,2. The mechanism of these findings is also unknown. The present report describes a study of creatine metabolism in chronic uremic rats. Creatine and GAA levels in plasma, liver and kidney were measured. GAT activity in the kidney was determined. Conversion of L-[guanidino-14C] arginine to creatine, GAA and urea was also measured in the plasma, kidney, liver and muscle.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. B. D. Cohen, Guanidinosuccinic acid in uremia, Arch. Intern. Med., 126: 846 (1970).

    Article  CAS  Google Scholar 

  2. M. Sasaki, K. Takahara and S. Natelson, Urinary guanidinoacetate/guanidinosuccinate ratio, an indicator of kidney dysfunction, Clin. Chem., 19: 315 (1973).

    PubMed  CAS  Google Scholar 

  3. J. F. Van Pilsum, D. Taylor, B. Zakis and P. McCormic, Simplified assay for transamidinase activities of rat kidney homogenates, Anal. Biochem., 35: 277 (1970).

    Google Scholar 

  4. M. Funahashi, H. Kato, S. Shiosaka and H. Nakagawa, Formation of arginine and guanidinoacetic acid in the kidney in vivo. Their relations with the liver and their regulation, J. Biochem., 89: 1347 (1981).

    PubMed  CAS  Google Scholar 

  5. M. Tsubakihara, Guanidinoacetic acid (GAA)-creatine metabolism in chronic renal failure rats, Proceedings of the 1st Meetin of Research Societ for Pathoenesis of Uremia, Japan, 54 (1982).

    Google Scholar 

  6. M. Wang, W. Chan, I. Schutz, J. D. Kopple and M. E. Swendseid, Plasma arginine and ornithine levels and selected enzyme activities in uremic rats fed various amounts of arginine, Life Sciences, 22: 2129 (1978).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Ist Department of Internal Medicine, St. Marianna University School of Medicine, Sugao, Miyamae-ku, Kawasaki, Japan

    S. Owada, S. Ozawa, M. Inouchi, Y. Kimura & M. Ishida

Authors
  1. S. Owada
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Ozawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Inouchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Y. Kimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Ishida
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Inst. for Neurobiology, Okayama University Medical School, Okayama 700, Japan

    Akitane Mori

  2. The Bronx Lebanon Hospital Center, Bronx, New York, USA

    B. D. Cohen

  3. Laboratory of Neurochemistry, Born-Bunge Foundation, Universitaire Instelling Antwerpen, 2610, Wilrijk, Belgium

    A. Lowenthal

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Springer Science+Business Media New York

About this chapter

Cite this chapter

Owada, S., Ozawa, S., Inouchi, M., Kimura, Y., Ishida, M. (1985). A Study of Creatine Metabolism in Chronic Renal Failure Rats. In: Mori, A., Cohen, B.D., Lowenthal, A. (eds) Guanidines. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0752-6_27

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-0752-6_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0754-0

  • Online ISBN: 978-1-4757-0752-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation