Abstract
The introduction of dialysis has made rapid progress in the field of research and clinical treatment of renal failure, and has contributed very much to physiological elucidation of uremia. In uremia, concentrations of serum creatinine, BUN (Blood urea nitrogen), uric acid and guanidino compounds increase, and abnormalities of water, electrolytes, and acid-base equilibrium are seen. In addition, there are still many unknown substances and unknown factors, which play an important role in this disease. These substances are generally called uremic toxins. It is essential to investigate uremic toxins for the elucidation of uremia and the establishment of proper dialysis. Many compounds from low molecular weight to middle molecular weight have been investigated as suspicious candidates for the uremic toxin. Among these compounds, guanidines such as methylguanidine (MG), guanidinosuccinic acid (GSA) and guanidine (G) have been suggested. These guanidino compounds are also considered as causes for abnormalities in brain metabolism.
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Higashidate, S., Maekubo, T., Saito, M., Senda, M., Hoshino, T. (1985). New High-Speed Fully Automated Guanidino Compound Analyzer. In: Mori, A., Cohen, B.D., Lowenthal, A. (eds) Guanidines. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0752-6_1
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DOI: https://doi.org/10.1007/978-1-4757-0752-6_1
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