Release of Drugs from IUDs Using an Ethylene Vinyl Acetate Matrix

  • R. G. Wheeler
  • P. G. Friel


The work of the International Fertility Research Program (IFRP) in the clinical evaluation and development of contraceptive methods is aimed primarily at meeting the needs of the developing world. In many places where the contraceptive need is greatest, the IUD is the only reliable method acceptable to many of the women desiring protection. A reduction of the explosive population growth in these countries could result from an improvement in the acceptance of IUDs or from the introduction of effective alternatives to the IUD. Contraceptives whose design is based on the sustained release of drugs may provide the needed improvement. Specifically, the purpose of this paper is to encourage more research and use of the sustained release of drugs from inert polymers in which the connectivity of the drug particles within the matrix is the principal avenue for drug release.


Sustained Release Contraceptive Method Uterine Horn Vaginal Ring Menstrual Blood Loss 
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  1. 1.
    D.H. Lewis, D.R. Cowsar, and M.D. Hamilton, in: “Proceedings 5th International Symposium on Controlled Release of Bioactive Materials,” F.E. Brinkman and J.A. Montemarano, eds., Gaithes- burg, Maryland (1978).Google Scholar
  2. 2.
    M.E. Tuttle and R.W. Baker, in: “Proceedings 7th International Symposium on Controlled Release of Bioactive Materials,” D.H. Lewis, ed., Ft. Lauderdale (1980).Google Scholar
  3. 3.
    R. Langer and J. Folkman, Nature 263: 797 (1976).PubMedCrossRefGoogle Scholar
  4. 4.
    G.A. More, in: “Fourth International Congress for Stereology,” N.B.S. Spcl. Pub. 431:41 (1976).Google Scholar
  5. 5.
    J. Guillebaud and J. Bonnar, Br. J. Obstet. Gynecol. 85: 707 (1978).CrossRefGoogle Scholar
  6. 6.
    A.J. Gallegos, R. Aznar, G. Merion, and E. Guizer, Contraception 17 (2): 153 (1978).CrossRefGoogle Scholar
  7. 7.
    P. Liedholm, G. Rybo, N.O. Sjoberg, and L. Solvell, Contraception 9(6): 627 (1974).Google Scholar
  8. 8.
    R. Malmquist, L. Petersohn, and L.P. Bengtsson, Contraception 9 (6): 627 (1974).CrossRefGoogle Scholar
  9. 9.
    C.G. Nilsson, Contraception 15 (4): 379 (1977).PubMedCrossRefGoogle Scholar
  10. 10.
    J. Guillebaud, J. Bonnar, J. Moregead, and A. Matthews, Lancet 387 (1976).Google Scholar
  11. 11.
    R. Rovera, J.R. Gaitan, C.L. Navarra, J. Valles, H. Almonte, R. Ruiz, and A.B. Hernandez, Contraception 17(3): 195 (1978).Google Scholar
  12. 12.
    F. Hefnawi, M.M. Yacout, M. Hosin, Z. El Sheika, and M. Hassanein, Int. J. Gynaecol. Obstet. 15: 79 (1977).PubMedGoogle Scholar
  13. 13.
    L. Westrom and L.P. Bengtsson, J. Reprod. Med. 5 (4): 41 (1970).Google Scholar
  14. 14.
    J.M. Kasonde and J. Bonnar, Br. Med. J. 4: 17 (1975).PubMedCrossRefGoogle Scholar
  15. 15.
    D.W. Nibbelink and C.D. Jakobsen, Thrombos. Diathes. Haemorrha. (Stag) 29: 508 (1973).Google Scholar
  16. 16.
    S.T. Shaw, D.L. Moyer, and D.E. Aaronson, et al., Contraception 11: 395 (1975).PubMedCrossRefGoogle Scholar
  17. 17.
    P.F. Tauber, A.S. Wolf, W. Herting, and L.J.D. Zoneveld, Fertil. Steril. 28 (12): 1375 (1977).PubMedGoogle Scholar
  18. 18.
    F.B.G. Schumacher, personal communication, U. of Chicago School of Medicine (1978).Google Scholar
  19. 19.
    K.P. Wood and K. Sangduk, Nature 202 (4934): 794 (1964).Google Scholar
  20. 20.
    D. Moyer, communication, Teratogenicity Testing. IFRP Library (1980).Google Scholar
  21. 21.
    W. Rinehart and L. Winter, Population Reports, Series K 1 (1975).Google Scholar
  22. 22.
    J. Bongaarts, Science, 208: 564 (1980).PubMedCrossRefGoogle Scholar
  23. 23.
    M. Chen, Int. Fam. Plann. Perspect. 5 (3): 92 (1979).CrossRefGoogle Scholar
  24. 24.
    G.W. Duncan and D.R. Kalkwarf, in: “Human Rep. Concept. and Contraception,” Harper and Row (1973). p. 483.Google Scholar
  25. 25.
    E.S.E. Hafez and W.A.A. Van Os, in: “Proc. Int. Symp. Amsterdam, Martinus Nijhoff,” The Hague (1979).Google Scholar
  26. 26.
    R.R. Chaudhury, Obstet. Gynecol. Surv. 35 (6): 333 (1980).PubMedCrossRefGoogle Scholar
  27. 27.
    G.I. Zatuchni, A.G. Sobrero, J.J. Speidel, and J.J. Sciarra, in: “Vaginal Contraception,” Harper and Row (1979).Google Scholar
  28. 28.
    Spec. Prog. of Res., Dey. and Res. Training, in Hum. Rep., WHO 7th Ann. Rpt. (1978).Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • R. G. Wheeler
    • 1
  • P. G. Friel
    • 1
  1. 1.International Fertility Research ProgramResearch Triangle ParkUSA

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