Biological Activities and Targeting of Soluble Macromolecules

  • Josef Pitha
  • John W. Kusiak


Macromolecules differ from small molecular-weight compounds in many aspects, and that has been the main reason for delays in their study and practical applications. Macromolecules may form an important class of drugs, but their potential in that respect, with the exception of polypeptidic hormones, still has not been realized. This review deals with the similarities in pharmacodynamic phases (drug-receptor interactions) of small and large molecular-weight compounds and the considerable differences these two classes show in pharmacokinetic phases (drug distribution) of their action. The results obtained both on synthetic and natural macromolecules are used as examples because of the interests of authors in synthetic macromolecules and their interactions with the cell or their components in vitro and in the field of enzyme replacement therapy, where effects of the introduction of enzymes into animals are studied. There is only a limited formal overlap between these fields; nevertheless, examination of respective results leads to similar conclusions, a situation which perhaps may be compared to a description of the same phenomena in different languages.


Sialic Acid Enzyme Replacement Therapy Permeation Rate Cyanogen Bromide Enzyme Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Josef Pitha
    • 1
  • John W. Kusiak
    • 1
  1. 1.Section on Macromolecules, National Institutes of Health National Institute on AgingGRC-Baltimore City HospitalsBaltimoreUSA

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