Anthracycline-DNA Complexes as Slow-Release Preparations in the Treatment of Acute Leukemia

  • Curt Peterson
  • Christer Paul
  • Gösta Gahrton


The anthracycline antibiotics daunorubicin (DNR) and doxorubicin (DOX, adriamycin) play a prominent role in the treatment of acute leukemia.1,2 The most successful programs for treatment of acute non-lymphoblastic leukemia (ANLL) in adults now cause remission in about 70–80% of previously untreated patients. But most patients relapse despite maintenance therapy given at certain intervals. The response rate is then much lower and most of these patients are resistant to the drugs which initially caused remission.


Leukemic Cell Cellular Uptake Acute Leukemia Free Drug Marker Enzyme 
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Curt Peterson
    • 1
  • Christer Paul
    • 2
  • Gösta Gahrton
    • 2
  1. 1.Department of PharmacologyKarolinska InstituteStockholmSweden
  2. 2.Section of Oncology and Hematology Department of MedicineHuddinge HospitalHuddingeSweden

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