Pharmacokinetic Modeling of Gentamicin Release from a Prosthetic Heart Valve
Sustained release of biological agents is a concept that has received increased attention over the past decade. The primary goal of sustained drug release is the prolonged delivery of a drug to a particular body compartment or anatomical target site. This goal is accomplished by the application of a therapeutic drug delivery system designed to control both temporal and spatial aspects of drug disposition.
KeywordsDrug Release Pharmacokinetic Model Silicone Rubber Prosthetic Valve Prosthetic Heart Valve
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- 1.R.D. Jones, L.S. Olanoff, and J.M. Anderson, First European Conference on Evaluation of Biomaterials, Strasbourg, France, September 26–28, 1977, in press Google Scholar
- 3.L.S. Olanoff, Ph.D. Thesis, Case Western Reserve University (1980).Google Scholar
- 11.J.S. Kent, in: “Controlled Release Polymeric Formulations,” D.R. Paul and F.W. Harris, ed, ACS Symposium Series, Vol. 33, American Chemical Society, Washington, D.C. (1976). pp. 157–170.Google Scholar
- 20.K.W. Miller, K.K.H. Chan, H.G. McCoy, R.P. Fischer, W.G. Lindsay, and D.E. Zaske, Clin. Pharmacol. Therap. 26: 54 (1979).Google Scholar
- 21.R.E. Polk, G.L. Archer, and R. Lower, Clin. Pharmacol. Therap. 23: 473 (1978)Google Scholar