Fibrous Polymers for the Delivery of Contraceptive Steroids to the Female Reproductive Tract
Research and development on the application of controlled-release technology to fertility regulation was initiated in the late 1960s and has been accelerated in recent years.1’2 Since sustained-release doses obviate the problem of cyclic overdosing and underdosing associated with the conventional administration of steroids, the technology, in principle, affords a means of effecting an optimum pharmacological response with a minimum dose of exogenous steroid.3 Depending upon the half-life of the drug in plasma, the duration of the dose regimen, and the route of administration, the total dose can be reduced to 1/100 or less for continuous versus intermittant delivery.
KeywordsFemale Reproductive Tract Contraceptive Steroid Sheath Thickness Polyethylene Fiber Core Matrix
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