Influence of Insulin and Glucagon on Ketogenesis by Isolated Rat Hepatocytes

  • William F. Woodside
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 111)


The quantitative roles of insulin and glucagon in the regulation of hepatic ketogenesis are still not defined adequately. Glucagon added in vitro has been reported by certain workers to stimulate ketogenesis in perfused livers from normal-fed rats (Heimberg, Weinstein, and Kohout, 1969; Weinstein, Klausner, and Heimberg, 1973). However, other workers did not observe a ketogenic effect of the hormone under similar conditions (McGarry and Foster, 1978; McGarry, Wright, and Foster, 1975).


Ketone Body Hormonal Control Perfuse Liver Alloxan Diabetes Hepatic Lipid Metabolism 
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Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • William F. Woodside
    • 1
  1. 1.Department of PharmacologyUniversity of New Mexico School of MedicineAlbuquerqueUSA

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