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Cell Impairment in Aging and Development pp 123–136Cite as

Alterations in Chromatin Functions during Aging in Vitro

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 53))

Abstract

Changes in the metabolism of the human diploid cell line WI-38 during the aging process have been extensively characterized. For example, studies have shown age-associated increases in glycogen content (1), lipid synthesis (2), lipid content (3), the number of lysosomes (4,5) and the specific activities of lysosomal enzymes (6–8). In addition, age related decreases in the specific activities of transketolase and 6-phosphogluconate dehydrogenase have also been reported (9). If these age-related changes represent the phenotype of fundamental changes in the expression of the cellular genome, then alterations in chromatin functions could underlie the modulation of the aging process. In this regard, the metabolic alterations mentioned earlier may only reflect functional changes as they occur within the cellular chromatin. However, few reports have been published on age-associated alterations in chromatin functions.

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Author information

Authors and Affiliations

  1. The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, 19104, USA

    Jon M. Ryan

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  1. Jon M. Ryan
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Editors and Affiliations

  1. Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

    Vincent J. Cristofalo

  2. Institute of Physiology, Czechoslovak Academy of Sciences, Budějovická 1083, 142 20, Prague 4, Czechoslovakia

    Emma Holečková

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© 1975 Springer Science+Business Media New York

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Ryan, J.M. (1975). Alterations in Chromatin Functions during Aging in Vitro . In: Cristofalo, V.J., Holečková, E. (eds) Cell Impairment in Aging and Development. Advances in Experimental Medicine and Biology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0731-1_9

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  • DOI: https://doi.org/10.1007/978-1-4757-0731-1_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0733-5

  • Online ISBN: 978-1-4757-0731-1

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