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Heritable Cell Cycle Disturbances and Late Recovery in X-Irradiated Murine Lymphoma L5178Y-S Cell Populations in Vitro

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Cell Impairment in Aging and Development

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 53))

Abstract

In the last decade the view has been expressed by several authors (1–4) that ageing of the normal mammalian cells is connected with the prolongation of the mitotic cycle. At the same time it has been shown that ionizing radiation can in vitro (5–10) and in vivo (11,12) induce in mammalian cells, besides the lethal effects, also some heritable damages which retard the cell cycle traverse for considerable number of cell generations.

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References

  1. . Macieira-Coelho, A., Ponten, J. and Philipson, L. 1966. The division cycle and RNA -synthesis in diploid human cells at different passage levels in vitro].; Exp. Cell Res. 42: 673.

    Google Scholar 

  2. Cristofalo, V.J. 197. Metabolic aspects of aging in diploid human cells, IN Aging in Cell and Tissue Cultures, E. Holekova and V.J. Cristofalo (editors), Plenum Press, New York-London

    Google Scholar 

  3. P. 83.

    Google Scholar 

  4. . Macieira-Coelho,,A. 1970. The decreased growth potential in of human fibroblasts of adult origin, IN Aging in Cell and Tissue Culture, E. Holeckova and V.J. Cristofalo (editors), Plenum Press, New York-London, p. 121.

    Book  Google Scholar 

  5. . Gelfant, S. and Smith, J.G., Jr. 1972. Aging: noncycling cells and explanation. Science 178: 3357.

    Article  Google Scholar 

  6. . Sinclair, W.K. 1964. X-ray-induced heritable damage (small colony formation) in cultured mammalian cells. Radiation Res. 21: 584.

    Article  PubMed  CAS  Google Scholar 

  7. Nias, A.H.W., Gilbert, C.W., Lajtha, LG. and Lange, C.S.

    Google Scholar 

  8. . Clone-size analysis in the study of cell growth following single or during continuous irradiation. Int. J. Radiat. Biol. 9: 275.

    Google Scholar 

  9. . Westra, A- and Barendsen, G.W. 1966. Proliferation characteristics of cultured mammalian cells after irradiation with sparsely and densely ionizing radiations. Int. J. Radiat. Biol. 11: 477.

    Google Scholar 

  10. . Beer, J.Z., Rosiek, 0. Sablinski, J. ï1, and Ziemba-Zak, B. Radiation-induced herbitale desions in cultures of murine leukaemic cells L5178Y. Studia Biophysica (Berlin) 6: 103.

    Google Scholar 

  11. Beer, J.Z. 1974. Late post-irradiation phenomena in mammalian cell populations. I. Radiation-induced heritable changes in X -irradiated;L518Y-S`cells in vitro. Institute of Nuclear Research (Warsaw) Report, in press.

    Google Scholar 

  12. Beer, J.Z. 1974. Late post-irradiation phenomena in mammalian cell populations III. Late recovery of slowly-growing clones isolated from X-irradiated L5178Y-S cell populations. Institute of Nuclear Research (Warsaw) Report, in press.

    Google Scholar 

  13. . Berry, R.J. 1967. “Small clones” in irradiated tumour cells in vivo. Kinetics of re-growth of murine leukaemia cells surviving irradiation with X-rays, fast neutrons and accelerated charged particles. Brit. J. Radiol, 40: 285

    Google Scholar 

  14. Berry, R.J. `’1972.’ Differences in LET dependence of cell killing and the production of heritable non-lethal damage in mammalian systems. IN Radiobiological Applications of Neutron Irradiation. Intern. Atomic Energy Agency. Vienna, p. ‘89.

    Google Scholar 

  15. . Fischer, G.A. 1958. Studies of the culture of leukaemic cells in vitro. Ann. N.Y.’,Ac. Sci. 76: 673.

    Google Scholar 

  16. Alexander, P. and iikulski, Z.B. ‘1961. Mouse lymphoma cells with different radiosensitivities. Nature 192: 572

    Google Scholar 

  17. . Beer, J.Z., Lett, J.T.`and Alexander, P. 1963. Influence of temperature and medium on the X-ray sensitivities of leukaemia cells in vitro. Nature 199: 193.

    Google Scholar 

  18. . Szumiel, I.,’,Ziemba-Zak, B.,’Rosiek, 0., Sablinski, J. and Beer, J.Z. Harmful effects of an irradiated cell culture medium. Int. J.’P.adiat. Biol. 20: 153.

    Google Scholar 

  19. . Paul, J. 1960. Cell and tissue culture. E. and S. Livingstone, Edinburgh.

    Google Scholar 

  20. . Fox, M. and Gilbert, C.W. 1966. Continuous irradiation of a murine lymphoma line P388F in vitro. Int. J. Radiat. Biol. 11:, 339.

    Google Scholar 

  21. . Beer, J.Z. Ziemba-Zak,;B I. and Kopec, N. 1970. activity in the progeny irradiated with X-rays. Biol. 18: 581. Posieh, 0., Sablinski, J., Szumiel, Regeneration of proliferative of murine lymphoma cells L5178Y Bull. Ac. Polon. Sci., Ser. Sci.

    Google Scholar 

  22. . Szumiel, I.,“nosiek, 0.,’ Beer, J.Z., Budzicka, E., Sablinski, J. and Kopec, M. 1973. Histone Fl phosphorus content and DNA symthesis in slowly-growing sublines of L5178Y-S cells. Bull. Ac. Polon. Sci., Ser. Sci. Biol. 21: 7.

    Google Scholar 

  23. Beer, J.Z., Bocian, E., Budzicka, E., Szumiel, I.,,Zíemba-Zak, and Kopec, M. 1974. Cell cycle disturbances in slowly growing sublines isolated from X-irradiated L5178Y-S cell populations. Nukleonika, in press.

    Google Scholar 

  24. . Mendelsohn, M,L, and Takahashi,:í,’’ 1971. A critical evaluation of the fraction of labelled mitoses method as applied to analysis of tumor and other cell cycles. IN The Cell Cycle and Cancer, Baserga, R. and Dekker, M. ( editors ), New York, p. 58.

    Google Scholar 

  25. . Sinclair, W.K. and Morton, R.A. 1966. X-ray sensitivity during the cell generation cycle of cultured Chinese hamster° cells. Radiation Res. 29: 450.

    Article  PubMed  CAS  Google Scholar 

  26. . Stanners, C.P. and Till, J.E. 1960, DNA synthesis in individual -L-strain mouse cells. Biochim. Biophys. Acta.` 37: 406.

    Google Scholar 

  27. Szumiel, I. and Beer, J.Z. 1974. Late post-irradiation phenomena in mammalian cell population. V. Cytokinetic parameters of the slowly growing sublines isolated from S-irradiated L5178Y-S cell populations and “division probability”. Institute of Nuclear Research`(Warsaw) Report, in press.

    Google Scholar 

  28. Smith,’J.A. 1973. Regulation of the cell cycle in animal cells. Biochem. Soc..Trans. ‘1 1078.

    Google Scholar 

  29. . Littlefield, J.W.’; 1963. The inosinic acid pyrophosphorylase activity of mouse fibroblasts partially resistant to 8- azaguanine. Proc. Nat. Acad. Aci. U.S.A. 50: 568.

    Google Scholar 

  30. . rlezger-Freed, L. -`1971. Puromycin resistance in haploid and heteroploid frog cells gene or membrane determined? J. Cell. Biol. 51: 742.

    Google Scholar 

  31. . Thompson, L.H., r-íankovitz, R.,’ Baker, R.iI., Wright„ J.A., Till, J.E., Siminovitch, L. and Whitmore, G.F. 1971. Selective and nonselective isolation of temperature-sensitive mutants of mouse %L-cells and their characterization. J. Cell Physiol. 78: 431.

    CAS  Google Scholar 

  32. . Morgan, H. 1971. Hutation rates in cells at different ploidy J. Cell Physiol. 78: 177.

    Article  Google Scholar 

  33. . Mexger-Freed, L. 1972. Effect of ploidy and mutagens on resistance in haploid and diploid frog cells. Nature (New Biol.) 235: 245.

    Google Scholar 

  34. . Heiss, H.K. and Basilica, C. 1972. Temperature sensitive mutants of’-BHK 21 cells, Nature (New Biol.) 239: 66.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Radiobiology and Health Protection, Institute of Nuclear Research, 03-195, Warszawa-Zeran, Poland

    Janusz Z. Beer & Irena Szumiel

Authors
  1. Janusz Z. Beer
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  2. Irena Szumiel
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Editor information

Editors and Affiliations

  1. Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

    Vincent J. Cristofalo

  2. Institute of Physiology, Czechoslovak Academy of Sciences, Budějovická 1083, 142 20, Prague 4, Czechoslovakia

    Emma Holečková

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© 1975 Springer Science+Business Media New York

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Beer, J.Z., Szumiel, I. (1975). Heritable Cell Cycle Disturbances and Late Recovery in X-Irradiated Murine Lymphoma L5178Y-S Cell Populations in Vitro . In: Cristofalo, V.J., Holečková, E. (eds) Cell Impairment in Aging and Development. Advances in Experimental Medicine and Biology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0731-1_42

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  • DOI: https://doi.org/10.1007/978-1-4757-0731-1_42

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0733-5

  • Online ISBN: 978-1-4757-0731-1

  • eBook Packages: Springer Book Archive

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