Biosynthesis of Collagen during the Life Cycle of Human Diploid Cell Lines

  • J. Hurych
  • M. Macek
  • K. Smetana
  • F. Beniač
  • D. Řezáčová
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 53)


The senescence of human diploid fibroblasts and their limited lifespan in vitro, shown by Hayflick and Moorhead (1), suggested a possible relationship between these events and ageing in vivo. In this paper we report our observations concerning the problems of collagen synthesis of human diploid cell strains during their long term in vitro cultivation.


Collagen Synthesis Marfan Syndrome Collagen Metabolism Human Diploid Fibroblast Human Diploid Cell 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • J. Hurych
    • 1
  • M. Macek
    • 1
  • K. Smetana
    • 1
  • F. Beniač
    • 1
  • D. Řezáčová
    • 1
  1. 1.Centre of Industrial Hygiene and Occupational DiseasesCharles University, Czechoslovak Academy of Sciences and Institute of Sera and VaccinesPragueCzech Republic

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